{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T09:17:40Z","timestamp":1781083060728,"version":"3.54.1"},"reference-count":27,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>When the blood supply ceases in a deceased organ donor, ischaemic injury starts. Kidneys are cooled to reduce cellular metabolism and minimize ischaemic injury. This cooling is slow and kidneys are lukewarm during nephrectomy. Smaller single-centre studies have shown that prolonged donor nephrectomy time decreases early kidney transplant function, but the effect on long-term outcome has never been investigated in large multicentre cohort studies.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>The relationship between donor nephrectomy time and death-censored graft survival was evaluated in recipients of single adult-to-adult, first-time deceased-donor kidneys transplanted in the Eurotransplant region between 2004 and 2013.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 13 914 recipients were included. Median donor nephrectomy time was 51 (i.q.r. 39\u201365) min. Kidneys donated after circulatory death had longer nephrectomy times than those from brain-dead donors: median 57 (43\u201378) versus 50 (39\u201364) min respectively (P &amp;lt; 0\u00b7001). Donor nephrectomy time was independently associated with graft loss when kidneys were donated after circulatory death: adjusted hazard ratio (HR) 1\u00b705 (95 per cent c.i. 1\u00b701 to 1\u00b709) per 10-min increase (P = 0\u00b7026). The magnitude of this effect was comparable to the effect of each hour of additional cold ischaemia: HR 1\u00b704 (1\u00b701 to 1\u00b707) per h (P = 0\u00b7004). For kidneys donated after brain death, there was no effect of nephrectomy time on graft survival: adjusted HR 1\u00b701 (0\u00b798 to 1\u00b704) per 10 min (P = 0\u00b7464).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Prolonged donor nephrectomy time impairs graft outcome in kidneys donated after circulatory death. Keeping this short, together with efficient cooling during nephrectomy, might improve outcome.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.11316","type":"journal-article","created":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T11:19:46Z","timestamp":1569928786000},"page":"87-95","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Effect of donor nephrectomy time during circulatory-dead donor kidney retrieval on transplant graft failure"],"prefix":"10.1093","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4595-0195","authenticated-orcid":false,"given":"L","family":"Heylen","sequence":"first","affiliation":[{"name":"Department of Nephrology, University Hospitals Leuven , Leuven,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Pirenne","sequence":"additional","affiliation":[{"name":"Department of Abdominal Transplant Surgery, University Hospitals Leuven , Leuven,","place":["Belgium"]},{"name":"Abdominal Transplantation, Transplantation Research Group, KU Leuven , Leuven,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"U","family":"Samuel","sequence":"additional","affiliation":[{"name":"Eurotransplant International Foundation , Leiden,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I","family":"Tieken","sequence":"additional","affiliation":[{"name":"Eurotransplant International Foundation , Leiden,","place":["the Netherlands"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Coemans","sequence":"additional","affiliation":[{"name":"Nephrology and Renal Transplantation Research Group, KU Leuven , Leuven,","place":["Belgium"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Naesens","sequence":"additional","affiliation":[{"name":"Department of Nephrology, University 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