{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T08:45:46Z","timestamp":1780735546111,"version":"3.54.1"},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[2021,1,27]],"date-time":"2021-01-27T00:00:00Z","timestamp":1611705600000},"content-version":"vor","delay-in-days":477,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T00:00:00Z","timestamp":1570492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T00:00:00Z","timestamp":1570492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,10,22]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Marking the axilla with radioactive iodine seed and sentinel lymph node (SLN) biopsy have been proposed for axillary staging after neoadjuvant systemic therapy in clinically node-positive breast cancer. This study evaluated the identification rate and detection of residual disease with combined excision of pretreatment-positive marked lymph nodes (MLNs) together with SLNs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>This was a multicentre retrospective analysis of patients with clinically node-positive breast cancer undergoing neoadjuvant systemic therapy and the combination procedure (with or without axillary lymph node dissection). The identification rate and detection of axillary residual disease were calculated for the combination procedure, and for MLNs and SLNs separately.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>At least one MLN and\/or SLN(s) were identified by the combination procedure in 138 of 139 patients (identification rate 99\u00b73 per cent). The identification rate was 92\u00b78 per cent for MLNs alone and 87\u00b78 per cent for SLNs alone. In 88 of 139 patients (63\u00b73 per cent) residual axillary disease was detected by the combination procedure. Residual disease was shown only in the MLN in 20 of 88 patients (23 per cent) and only in the SLN in ten of 88 (11 per cent), whereas both the MLN and SLN contained residual disease in the remainder (58 of 88, 66 per cent).<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Excision of the pretreatment-positive MLN together with SLNs after neoadjuvant systemic therapy in patients with clinically node-positive disease resulted in a higher identification rate and improved detection of residual axillary disease.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.11320","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T14:55:51Z","timestamp":1570546551000},"page":"1632-1639","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Excision of both pretreatment marked positive nodes and sentinel nodes improves axillary staging after neoadjuvant systemic therapy in breast cancer"],"prefix":"10.1093","volume":"106","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1264-4693","authenticated-orcid":false,"given":"J M","family":"Simons","sequence":"first","affiliation":[{"name":"Department of Surgical Oncology, Erasmus Medical Centre Rotterdam , Rotterdam, the Netherlands"},{"name":"Department of Surgical Oncology, University Medical Centre Utrecht, Utrecht University , Utrecht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M L M A","family":"van Pelt","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Haaglanden Medical Centre , The Hague, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A W K S","family":"Marinelli","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Haaglanden Medical Centre , The Hague, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M E","family":"Straver","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Haaglanden Medical Centre , The Hague, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A M","family":"Zeillemaker","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Alrijne Hospital , Leiderdorp, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L M","family":"Pereira Arias-Bouda","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Alrijne Hospital , Leiderdorp, the Netherlands"},{"name":"Section of Nuclear Medicine, Department of Radiology, Leiden University Medical Centre , Leiden, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T J A","family":"van Nijnatten","sequence":"additional","affiliation":[{"name":"Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre+ , Maastricht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L B","family":"Koppert","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Erasmus Medical Centre Rotterdam , Rotterdam, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K K","family":"Hunt","sequence":"additional","affiliation":[{"name":"Department of Breast Surgical Oncology, University of Texas MD Anderson Cancer Center , Houston, Texas, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M L","family":"Smidt","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Maastricht University Medical Centre+ , Maastricht, the Netherlands"},{"name":"GROW \u2013 School for Oncology and Developmental Biology, Maastricht University Medical Centre+ , Maastricht, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E J T","family":"Luiten","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, Amphia Hospital , Breda, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C C","family":"van der Pol","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology, University Medical Centre Utrecht, Utrecht University , Utrecht, the Netherlands"},{"name":"Department of Surgical Oncology, Alrijne Hospital , Leiderdorp, the Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2019,10,8]]},"reference":[{"key":"2022100812450457700_bjs11320-bib-0001","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/SLA.0000000000003075","article-title":"Diagnostic accuracy of different surgical procedures for axillary staging after neoadjuvant systemic therapy in node-positive breast cancer: a systematic review and 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