{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:30:48Z","timestamp":1780414248067,"version":"3.54.1"},"reference-count":12,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Schwannomas are rare tumours that pose a significant management challenge in the abdomen, retroperitoneum and pelvis. No data are available to inform management strategy.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A collaborative international cohort study, across specialist sarcoma units, was conducted to include adults presenting between 2000 and 2017 with histopathologically confirmed schwannomas within the abdomen, retroperitoneum or pelvis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Of 485 patients across 12 centres, 38 (7\u00b78 per cent) were discharged without follow-up, 199 (41\u00b70 per cent) underwent early resection and 248 (51\u00b71 per cent) had radiological monitoring. Of these 248 patients, 96 (38\u00b77 per cent) eventually had surgery, giving an overall resection rate of 60\u00b78 per cent (295 of 485). At baseline, median tumour volume was 90\u00b71 (i.q.r. 26\u00b75\u2013262\u00b70)\u00a0cm3. The estimated growth rate was 10\u00b75 (95 per cent c.i. 9\u00b74 to 11\u00b76) per cent per year, and was consistent in the short term (within 2 years of diagnosis) and long term (beyond 2 years) (\u03c1 = 0\u00b7405, P = 0\u00b7021). A decision to operate was more common in symptomatic patients (P &amp;lt; 0\u00b7001) and for rapidly growing tumours (growth rate more than 20 per cent per year) (P = 0\u00b7025). R0\/R1 resection was achieved in 91\u00b76 per cent of patients (263 of 287). Kaplan\u2013Meier long-term recurrence rates after R0\/R1 resection were 2\u00b73 and 6\u00b77 per cent at 3 and 5 years respectively.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>Specific recommendations include: indications for early surgery, prediction of growth from radiological monitoring, promotion of selective submacroscopic resection and cessation of postoperative imaging surveillance.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.11376","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T07:20:27Z","timestamp":1574061627000},"page":"452-463","source":"Crossref","is-referenced-by-count":21,"title":["Intercontinental collaborative experience with abdominal, retroperitoneal and pelvic schwannomas"],"prefix":"10.1093","volume":"107","author":[{"name":"Transatlantic Australasian Retroperitoneal Sarcoma Working 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