{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T15:50:32Z","timestamp":1791993032034,"version":"4.4.0"},"reference-count":35,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[2021,1,14]],"date-time":"2021-01-14T00:00:00Z","timestamp":1610582400000},"content-version":"vor","delay-in-days":316,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,3,18]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Most serous ovarian cancers are now understood to originate in the fallopian tubes. Removing the tubes (salpingectomy) likely reduces the risk of developing high-grade serous ovarian cancer. Numerous gynaecological societies now recommend prophylactic (or opportunistic) salpingectomy at the time of gynaecological surgery in appropriate women, and this is widely done. Salpingectomy at the time of non-gynaecological surgery has not been explored and may present an opportunity for primary prevention of ovarian cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study investigated whether prophylactic salpingectomy with the intention of reducing the risk of developing ovarian cancer would be accepted and could be accomplished at the time of elective laparoscopic cholecystectomy. Women aged at least 45 years scheduled for elective laparoscopic cholecystectomy were recruited. They were counselled and offered prophylactic bilateral salpingectomy at the time of cholecystectomy. Outcome measures were rate of accomplishment of salpingectomy, time and procedural steps needed for salpingectomy, and complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 105 patients were included in the study. The rate of acceptance of salpingectomy was approximately 60 per cent. Salpingectomy was performed in 98 of 105 laparoscopic cholecystectomies (93\u00b73 per cent) and not accomplished because of poor visibility or adhesions in seven (6\u00b77 per cent). Median additional operating time was 13 (range 4\u201345) min. There were no complications attributable to salpingectomy. One patient presented with ovarian cancer 28 months after prophylactic salpingectomy; histological re-evaluation of the tubes showed a previously undetected, focal serous tubal intraepithelial carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Prophylactic salpingectomy can be done during elective laparoscopic cholecystectomy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bjs.11419","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T08:34:21Z","timestamp":1583310861000},"page":"519-524","source":"Crossref","is-referenced-by-count":52,"title":["Prophylactic salpingectomy for prevention of ovarian cancer at the time of elective laparoscopic cholecystectomy"],"prefix":"10.1093","volume":"107","author":[{"given":"G","family":"Tomasch","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Medical University of Graz , Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Lemmerer","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medical University of Graz , Graz, Austria"},{"name":"Department of Surgery, Krankenhaus der Barmherzigen Br\u00fcder Graz , Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Oswald","sequence":"additional","affiliation":[{"name":"Department of Surgery, Krankenhaus der Elisabethinen Graz , Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Uranitsch","sequence":"additional","affiliation":[{"name":"Department of Surgery, Krankenhaus der Barmherzigen Br\u00fcder Graz , Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Schauer","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Krankenhaus der Barmherzigen Br\u00fcder Graz , Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A-M","family":"Sch\u00fctz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Medical University of Graz , Graz, Austria"},{"name":"Department of Surgery, Krankenhaus der Barmherzigen Br\u00fcder Graz , Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Bliem","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Medical University of Graz , Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Berger","sequence":"additional","affiliation":[{"name":"Department of Surgery, Krankenhaus der Barmherzigen Br\u00fcder Graz , Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P F J","family":"Lang","sequence":"additional","affiliation":[{"name":"Department of Gynaecology, Krankenhaus der Barmherzigen Br\u00fcder Graz , Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Rosanelli","sequence":"additional","affiliation":[{"name":"Department of Surgery, Krankenhaus der Elisabethinen Graz , Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Ronaghi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Krankenhaus der Barmherzigen Br\u00fcder St Veit an der Glan , Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Tschmelitsch","sequence":"additional","affiliation":[{"name":"Department of Surgery, Krankenhaus der Barmherzigen Br\u00fcder St Veit an der Glan , Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S F","family":"Lax","sequence":"additional","affiliation":[{"name":"Department of Pathology, Landeskrankenhaus Graz II , Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6085-8362","authenticated-orcid":false,"given":"S","family":"Uranues","sequence":"additional","affiliation":[{"name":"Department of Surgery, Medical University of Graz , Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5016-4669","authenticated-orcid":false,"given":"K","family":"Tamussino","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Medical University of Graz , Graz, Austria"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,3,4]]},"reference":[{"key":"2022100812513652100_bjs11419-bib-0001","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1016\/S0140-6736(18)32552-2","article-title":"Epithelial ovarian cancer","volume":"393","author":"Lheureux","year":"2019","journal-title":"Lancet"},{"key":"2022100812513652100_bjs11419-bib-0002","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/S0140-6736(15)01224-6","article-title":"Ovarian cancer screening and mortality in the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS): a randomised controlled trial","volume":"387","author":"Jacobs","year":"2016","journal-title":"Lancet"},{"key":"2022100812513652100_bjs11419-bib-0003","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1001\/jama.2017.21421","article-title":"Screening for ovarian cancer: updated evidence report and systematic review for the US Preventive Services Task Force","volume":"319","author":"Henderson","year":"2018","journal-title":"JAMA"},{"key":"2022100812513652100_bjs11419-bib-0004","doi-asserted-by":"crossref","first-page":"1093","DOI":"10.1038\/s41467-017-00962-1","article-title":"High grade serous ovarian carcinomas originate in the fallopian tube","volume":"8","author":"Labidi-Galy","year":"2017","journal-title":"Nat Commun"},{"key":"2022100812513652100_bjs11419-bib-0005","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.humpath.2011.03.003","article-title":"Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer \u2013 shifting the paradigm","volume":"42","author":"Kurman","year":"2011","journal-title":"Hum Pathol"},{"key":"2022100812513652100_bjs11419-bib-0006","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1016\/j.ajpath.2015.11.011","article-title":"The dualistic model of ovarian carcinogenesis revisited, revised and expanded","volume":"186","author":"Kurman","year":"2016","journal-title":"Am J Pathol"},{"key":"2022100812513652100_bjs11419-bib-0007","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.ygyno.2018.11.033","article-title":"The fallopian tube, \u2018precursor escape\u2019 and narrowing the knowledge gap to the origins of high-grade serous carcinoma","volume":"152","author":"Soong","year":"2019","journal-title":"Gynecol Oncol"},{"key":"2022100812513652100_bjs11419-bib-0008","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.ygyno.2019.08.029","article-title":"Defining the molecular evolution of extrauterine high grade serous carcinoma","volume":"155","author":"Beirne","year":"2019","journal-title":"Gynecol Oncol"},{"key":"2022100812513652100_bjs11419-bib-0009","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1002\/path.1000","article-title":"Dysplastic changes in prophylactically removed Fallopian tubes of women predisposed to developing ovarian cancer","volume":"195","author":"Piek","year":"2001","journal-title":"J Pathol"},{"key":"2022100812513652100_bjs11419-bib-0010","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1093\/humupd\/dmq030","article-title":"Tubal ligation and the risk of ovarian cancer: review and meta-analysis","volume":"17","author":"Cibula","year":"2011","journal-title":"Hum Reprod Update"},{"key":"2022100812513652100_bjs11419-bib-0011","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1111\/aogs.12516","article-title":"Tubal ligation and salpingectomy and the risk of epithelial ovarian cancer and borderline tumors: a nationwide case\u2013control study","volume":"94","author":"Madsen","year":"2015","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2022100812513652100_bjs11419-bib-0012","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1093\/ije\/dyt042","article-title":"Ovarian Cancer Association Consortium. Tubal ligation and risk of ovarian cancer subtypes: a pooled analysis of case\u2013control studies","volume":"42","author":"Sieh","year":"2013","journal-title":"Int J Epidemiol"},{"key":"2022100812513652100_bjs11419-bib-0013","doi-asserted-by":"crossref","first-page":"ii","DOI":"10.1093\/jnci\/dju410","article-title":"Ovarian cancer risk after salpingectomy: a nationwide population-based study","volume":"107","author":"Falconer","year":"2015","journal-title":"J Natl Cancer Inst"},{"key":"2022100812513652100_bjs11419-bib-0014","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1038\/bjc.2016.80","article-title":"Tubal ligation and incidence of 26 site-specific cancers in the Million Women Study","volume":"114","author":"Gaitskell","year":"2016","journal-title":"Br J Cancer"},{"key":"2022100812513652100_bjs11419-bib-0015","author":"Society of Gynecologic Oncology of Canada","year":"2011","journal-title":"SGOC Statement Regarding Salpingectomy and Ovarian Cancer Prevention"},{"key":"2022100812513652100_bjs11419-bib-0016","volume-title":"The Distal Fallopian Tube as the Origin of Non-Uterine Pelvic High-Grade Serous Carcinomas","author":"Royal College of Obstetricians and Gynaecologists","year":"2014"},{"key":"2022100812513652100_bjs11419-bib-0017","author":"Royal Australian and New Zealand College of Obstetricians and Gynaecologists","year":"2014","journal-title":"Managing the Adnexae at the time of Hysterectomy for Benign Gynaecological Disease"},{"key":"2022100812513652100_bjs11419-bib-0018","doi-asserted-by":"crossref","first-page":"e279","DOI":"10.1097\/AOG.0000000000003164","article-title":"Opportunistic salpingectomy as a strategy for epithelial ovarian cancer prevention","volume":"133","author":"ACOG Committee Opinion No. 774","year":"2019","journal-title":"Obstet Gynecol"},{"key":"2022100812513652100_bjs11419-bib-0019","author":"Gynecologic Oncology Working Group of the Austrian Society of Obstetrics and Gynaecology and the Austrian Society of Pathology","year":"2015","journal-title":"Elective Salpingectomy for Prevention of Epithelial Ovarian Cancer"},{"key":"2022100812513652100_bjs11419-bib-0020","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ejogrb.2018.03.043","article-title":"Opportunistic salpingectomy for prevention of ovarian cancer: what do national societies advise?","volume":"225","author":"Ntoumanoglou-Schuiki","year":"2018","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2022100812513652100_bjs11419-bib-0021","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1097\/AOG.0000000000002243","article-title":"The evolution of and evidence for opportunistic salpingectomy","volume":"130","author":"Dilley","year":"2017","journal-title":"Obstet Gynecol"},{"key":"2022100812513652100_bjs11419-bib-0022","doi-asserted-by":"crossref","first-page":"172.e1","DOI":"10.1016\/j.ajog.2018.05.019","article-title":"Extending the safety evidence for opportunistic salpingectomy in prevention of ovarian cancer: a cohort study from British Columbia, Canada","volume":"219","author":"Hanley","year":"2018","journal-title":"Am J Obstet Gynecol"},{"key":"2022100812513652100_bjs11419-bib-0023","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.ygyno.2017.05.034","article-title":"Cost-effectiveness of opportunistic salpingectomy for ovarian cancer prevention","volume":"146","author":"Dilley","year":"2017","journal-title":"Gynecol Oncol"},{"key":"2022100812513652100_bjs11419-bib-0024","doi-asserted-by":"crossref","first-page":"270.e1","DOI":"10.1016\/j.ajog.2016.10.035","article-title":"The performance and safety of bilateral salpingectomy for ovarian cancer prevention in the United States","volume":"216","author":"Hanley","year":"2017","journal-title":"Am J Obstet Gynecol"},{"key":"2022100812513652100_bjs11419-bib-0025","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/ajo.12582","article-title":"Taking the tube: uptake of salpingectomy at the time of benign hysterectomy for benign indications","volume":"57","author":"Lin","year":"2017","journal-title":"Aust NZ J Obstet Gynaecol"},{"key":"2022100812513652100_bjs11419-bib-0026","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1055\/s-0042-116493","article-title":"Incidental (prophylactic) salpingectomy at benign gynecologic surgery and cesarean section: a survey of practice in Austria","volume":"76","author":"Potz","year":"2016","journal-title":"Geburtshilfe Frauenheilkd"},{"key":"2022100812513652100_bjs11419-bib-0027","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1097\/AOG.0000000000002312","article-title":"Salpingectomy for sterilization \u2013 change in practice in a large integrated health care system, 2011\u20132016","volume":"130","author":"Powell","year":"2017","journal-title":"Obstet Gynecol"},{"key":"2022100812513652100_bjs11419-bib-0028","doi-asserted-by":"crossref","first-page":"g2669","DOI":"10.1136\/bmj.g2669","article-title":"Gallstones","volume":"348","author":"Gurusamy","year":"2014","journal-title":"BMJ"},{"key":"2022100812513652100_bjs11419-bib-0029","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1056\/NEJMra1411372","article-title":"Interventional approaches to gallbladder disease","volume":"373","author":"Baron","year":"2015","journal-title":"N Engl J Med"},{"key":"2022100812513652100_bjs11419-bib-0030","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1001\/jama.2018.3438","article-title":"Laparoscopic cholecystectomy","volume":"319","author":"Kim","year":"2018","journal-title":"JAMA"},{"key":"2022100812513652100_bjs11419-bib-0031","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1016\/j.surg.2018.03.024","article-title":"Would women accept opportunistic (prophylactic) salpingectomy at the time of nongynecologic surgery to prevent development of ovarian cancer?","volume":"164","author":"Tomasch","year":"2018","journal-title":"Surgery"},{"key":"2022100812513652100_bjs11419-bib-0032","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1097\/01.pas.0000180854.28831.77","article-title":"The tubal fimbria is a preferred site for early adenocarcinoma in women with familial ovarian cancer syndrome","volume":"30","author":"Medeiros","year":"2006","journal-title":"Am J Surg Pathol"},{"key":"2022100812513652100_bjs11419-bib-0033","doi-asserted-by":"crossref","first-page":"471.e1","DOI":"10.1016\/j.ajog.2014.01.003","article-title":"Opportunistic salpingectomy: uptake, risks, and complications of a regional initiative for ovarian cancer prevention","volume":"201","author":"McAlpine","year":"2014","journal-title":"Am J Obstet Gynecol"},{"key":"2022100812513652100_bjs11419-bib-0034","doi-asserted-by":"crossref","first-page":"pky061","DOI":"10.1093\/jncics\/pky061","article-title":"Population frequency of serous tubal intra-epithelial carcinoma (STIC) in clinical practice using SEE-Fim protocol","volume":"2","author":"Samimi","year":"2018","journal-title":"JNCI Cancer Spectr"},{"key":"2022100812513652100_bjs11419-bib-0035","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1016\/j.surg.2018.05.004","article-title":"Opportunistic salpingectomy to decrease the mortality from ovarian cancer: can we expand the pool of eligible patients?","volume":"164","author":"Bakkum-Gamez","year":"2018","journal-title":"Surgery"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.11419","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/107\/5\/519\/46378890\/bjs11419.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/107\/5\/519\/46378890\/bjs11419.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T09:21:49Z","timestamp":1665220909000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/107\/5\/519\/6093611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,4]]},"references-count":35,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2020,3,4]]},"published-print":{"date-parts":[[2020,3,18]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.11419","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,4]]},"published":{"date-parts":[[2020,3,4]]}}}