{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T15:43:13Z","timestamp":1792510993634,"version":"4.5.0"},"reference-count":47,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH\/NCI Cancer Center Support Grant","doi-asserted-by":"publisher","award":["P30 CA008748"],"award-info":[{"award-number":["P30 CA008748"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,8,24]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Nipple-sparing mastectomy (NSM) is being performed increasingly for risk reduction in high-risk groups. There are limited data regarding complications and oncological outcomes in women undergoing bilateral prophylactic NSM. This study reviewed institutional experience with prophylactic NSM, and examined the indications, rates of postoperative complications, incidence of occult malignant disease and subsequent breast cancer diagnosis.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>Women who had bilateral prophylactic NSM between 2000 and 2016 were identified from a prospectively maintained database. Rates of postoperative complications, incidental breast cancer, recurrence and overall survival were evaluated.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>A total of 192 women underwent 384 prophylactic NSMs. Indications included BRCA1 or BRCA2 mutations in 117 patients (60\u00b79 per cent), family history of breast cancer in 35 (18\u00b72 per cent), lobular carcinoma in situ in 29 (15\u00b71 per cent) and other reasons in 11 (5\u00b77 per cent). Immediate breast reconstruction was performed in 191 patients. Of 384 NSMs, 116 breasts (30\u00b72 per cent) had some evidence of skin necrosis at follow-up, which resolved spontaneously in most; only 24 breasts (6\u00b73 per cent) required debridement. Overall, there was at least one complication in 129 breasts (33\u00b76 per cent); 3\u00b76 and 1\u00b76 per cent had incidental findings of ductal carcinoma in situ and invasive breast cancer respectively. The nipple\u2013areola complex was preserved entirely in 378 mastectomies. After a median follow-up of 36\u00b78 months, there had been no deaths and no new breast cancer diagnoses.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>These findings support the use of prophylactic NSM in high-risk patients. The nipples could be preserved in the majority of patients, postoperative complication rates were low, and, with limited follow-up, there were no new breast cancers.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.11616","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T11:56:24Z","timestamp":1589975784000},"page":"1307-1312","source":"Crossref","is-referenced-by-count":23,"title":["Use of bilateral prophylactic nipple-sparing mastectomy in patients with high risk of breast cancer"],"prefix":"10.1093","volume":"107","author":[{"given":"M G","family":"Valero","sequence":"first","affiliation":[{"name":"Breast Service, Department of Surgery , New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T-A","family":"Moo","sequence":"additional","affiliation":[{"name":"Breast Service, Department of Surgery , New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S","family":"Muhsen","sequence":"additional","affiliation":[{"name":"Breast Service, Department of Surgery , New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E C","family":"Zabor","sequence":"additional","affiliation":[{"name":"Biostatistics Service, Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center , New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Stempel","sequence":"additional","affiliation":[{"name":"Breast Service, Department of Surgery , New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Pusic","sequence":"additional","affiliation":[{"name":"Division of Plastic Surgery, Brigham and Women's Hospital at Harvard Medical School , Boston, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M L","family":"Gemignani","sequence":"additional","affiliation":[{"name":"Breast Service, Department of Surgery , New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M","family":"Morrow","sequence":"additional","affiliation":[{"name":"Breast Service, Department of Surgery , New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0409-9111","authenticated-orcid":false,"given":"V","family":"Sacchini","sequence":"additional","affiliation":[{"name":"Breast Service, Department of Surgery , New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,20]]},"reference":[{"key":"2022100812525139900_bjs11616-bib-0001","doi-asserted-by":"crossref","first-page":"3317","DOI":"10.1245\/s10434-015-4737-3","article-title":"Expanded indications and improved outcomes for nipple-sparing mastectomy over time","volume":"22","author":"Krajewski","year":"2015","journal-title":"Ann Surg Oncol"},{"key":"2022100812525139900_bjs11616-bib-0002","doi-asserted-by":"crossref","first-page":"1329","DOI":"10.1200\/JCO.2006.09.1066","article-title":"Meta-analysis of BRCA1 and BRCA2 penetrance","volume":"25","author":"Chen","year":"2007","journal-title":"J Clin Oncol"},{"key":"2022100812525139900_bjs11616-bib-0003","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1126\/science.1088759","article-title":"Breast and ovarian cancer risks due to inherited mutations in BRCA1 and BRCA2","volume":"302","author":"King","year":"2003","journal-title":"Science"},{"key":"2022100812525139900_bjs11616-bib-0004","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1093\/jnci\/djt095","article-title":"EMBRACE. 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