{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T16:46:42Z","timestamp":1790786802860,"version":"4.1.0"},"reference-count":77,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[2020,5,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:sec>\n                  <jats:title>Background<\/jats:title>\n                  <jats:p>Organ transplantation is predicted to increase as life expectancy and the incidence of chronic diseases rises. Regenerative medicine-inspired technologies challenge the efficacy of the current allograft transplantation model.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Methods<\/jats:title>\n                  <jats:p>A literature review was conducted using the PubMed interface of MEDLINE from the National Library of Medicine. Results were examined for relevance to innovations of organ bioengineering to inform analysis of advances in regenerative medicine affecting organ transplantation. Data reports from the Scientific Registry of Transplant Recipient and Organ Procurement Transplantation Network from 2008 to 2019 of kidney, pancreas, liver, heart, lung and intestine transplants performed, and patients currently on waiting lists for respective organs, were reviewed to demonstrate the shortage and need for transplantable organs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Results<\/jats:title>\n                  <jats:p>Regenerative medicine technologies aim to repair and regenerate poorly functioning organs. One goal is to achieve an immunosuppression-free state to improve quality of life, reduce complications and toxicities, and eliminate the cost of lifelong antirejection therapy. Innovative strategies include decellularization to fabricate acellular scaffolds that will be used as a template for organ manufacturing, three-dimensional printing and interspecies blastocyst complementation. Induced pluripotent stem cells are an innovation in stem cell technology which mitigate both the ethical concerns associated with embryonic stem cells and the limitation of other progenitor cells, which lack pluripotency. Regenerative medicine technologies hold promise in a wide array of fields and applications, such as promoting regeneration of native cell lines, growth of new tissue or organs, modelling of disease states, and augmenting the viability of existing ex vivo transplanted organs.<\/jats:p>\n               <\/jats:sec>\n               <jats:sec>\n                  <jats:title>Conclusion<\/jats:title>\n                  <jats:p>The future of organ bioengineering relies on furthering understanding of organogenesis, in vivo regeneration, regenerative immunology and long-term monitoring of implanted bioengineered organs.<\/jats:p>\n               <\/jats:sec>","DOI":"10.1002\/bjs.11686","type":"journal-article","created":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T10:47:05Z","timestamp":1590662825000},"page":"793-800","source":"Crossref","is-referenced-by-count":190,"title":["Regenerative medicine, organ bioengineering and transplantation"],"prefix":"10.1093","volume":"107","author":[{"given":"L","family":"Edgar","sequence":"first","affiliation":[{"name":"Department of Surgery, Section of Transplantation, Wake Forest University School of Medicine , Winston Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Pu","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Transplantation, Wake Forest University School of Medicine , Winston Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"Porter","sequence":"additional","affiliation":[{"name":"University of Florida College of Medicine, Gainesville, Florida , USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J M","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Transplantation, Wake Forest University School of Medicine , Winston Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"La Pointe","sequence":"additional","affiliation":[{"name":"Sherbrooke University , Sherbrooke, Quebec, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Asthana","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Transplantation, Wake Forest University School of Medicine , Winston Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6460-7974","authenticated-orcid":false,"given":"G","family":"Orlando","sequence":"additional","affiliation":[{"name":"Department of Surgery, Section of Transplantation, Wake Forest University School of Medicine , Winston Salem, North Carolina, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2020,5,28]]},"reference":[{"key":"2022100812514283300_bjs11686-bib-0001","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1111\/ajt.15274","article-title":"OPTN\/SRTR 2017 annual data report: kidney","volume":"19","author":"Hart","year":"2019","journal-title":"Am J Transplant"},{"key":"2022100812514283300_bjs11686-bib-0002","doi-asserted-by":"crossref","first-page":"iii19","DOI":"10.1093\/ndt\/gfs284","article-title":"Chronic kidney disease: a research and public health priority","volume":"27","author":"Perico","year":"2012","journal-title":"Nephrol Dial Transplant"},{"key":"2022100812514283300_bjs11686-bib-0003","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1681\/ASN.2018050531","article-title":"Projecting ESRD incidence and prevalence in the United States through 2030","volume":"30","author":"McCullough","year":"2019","journal-title":"J Am Soc Nephrol"},{"key":"2022100812514283300_bjs11686-bib-0004","doi-asserted-by":"crossref","first-page":"e11864","DOI":"10.2196\/11864","article-title":"Racial, ethnic, and socioeconomic disparities in web-based patient portal usage among kidney and liver transplant recipients: cross-sectional study","volume":"21","author":"Wedd","year":"2019","journal-title":"J Med Internet Res"},{"key":"2022100812514283300_bjs11686-bib-0005","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1111\/ajt.15671","article-title":"Introduction","volume":"20","author":"OPTN\/SRTR 2018 annual data report","year":"2020","journal-title":"Am J Transplant"},{"key":"2022100812514283300_bjs11686-bib-0006","author":"Organ Procurement and Transplantation Network"},{"key":"2022100812514283300_bjs11686-bib-0007","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1097\/TP.0000000000002370","article-title":"Rethinking regenerative medicine from a transplant perspective (and vice versa)","volume":"103","author":"Orlando","year":"2019","journal-title":"Transplantation"},{"key":"2022100812514283300_bjs11686-bib-0008","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1056\/NEJMoa1506027","article-title":"Belatacept and long-term outcomes in kidney transplantation","volume":"374","author":"Vincenti","year":"2016","journal-title":"N Engl J Med"},{"key":"2022100812514283300_bjs11686-bib-0009","doi-asserted-by":"crossref","first-page":"1723","DOI":"10.1111\/ajt.12777","article-title":"Big data in organ transplantation: registries and administrative claims","volume":"14","author":"Massie","year":"2014","journal-title":"Am J Transplant"},{"key":"2022100812514283300_bjs11686-bib-0010","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.euf.2018.07.021","article-title":"Complete chain of the first global kidney exchange transplant and 3-yr follow-up","volume":"4","author":"Bozek","year":"2018","journal-title":"Eur Urol Focus"},{"key":"2022100812514283300_bjs11686-bib-0011","doi-asserted-by":"crossref","first-page":"940","DOI":"10.1056\/NEJMoa1508380","article-title":"Survival benefit with kidney transplants from HLA-incompatible live donors","volume":"374","author":"Orandi","year":"2016","journal-title":"N Engl J Med"},{"key":"2022100812514283300_bjs11686-bib-0012","doi-asserted-by":"crossref","first-page":"505","DOI":"10.7326\/M17-1449","article-title":"Reimagining halfway technologies with behavioral science","volume":"167","author":"Asch","year":"2017","journal-title":"Ann Intern Med"},{"key":"2022100812514283300_bjs11686-bib-0013","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1136\/gutjnl-2011-301111","article-title":"Cell and organ bioengineering technology as applied to gastrointestinal diseases","volume":"62","author":"Orlando","year":"2013","journal-title":"Gut"},{"key":"2022100812514283300_bjs11686-bib-0014","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1097\/SLA.0b013e318243a4db","article-title":"Regenerative medicine as applied to general surgery","volume":"255","author":"Orlando","year":"2012","journal-title":"Ann Surg"},{"key":"2022100812514283300_bjs11686-bib-0015","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1111\/j.1432-2277.2010.01182.x","article-title":"Regenerative medicine as applied to solid organ transplantation: current status and future challenges","volume":"24","author":"Orlando","year":"2011","journal-title":"Transpl Int"},{"key":"2022100812514283300_bjs11686-bib-0016","doi-asserted-by":"crossref","first-page":"1310","DOI":"10.1097\/TP.0b013e318219ebb5","article-title":"Regenerative medicine and organ transplantation: past, present, and future","volume":"91","author":"Orlando","year":"2011","journal-title":"Transplantation"},{"key":"2022100812514283300_bjs11686-bib-0017","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1586\/eci.10.101","article-title":"Transplantation as a subfield of regenerative medicine. Interview by Lauren Constable","volume":"7","author":"Orlando","year":"2011","journal-title":"Expert Rev Clin Immunol"},{"key":"2022100812514283300_bjs11686-bib-0018","doi-asserted-by":"crossref","first-page":"e36","DOI":"10.1097\/TP.0b013e31822f59d8","article-title":"How regenerative medicine may contribute to the achievement of an immunosuppression-free state","volume":"92","author":"Orlando","year":"2011","journal-title":"Transplantation"},{"key":"2022100812514283300_bjs11686-bib-0019","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1097\/MOO.0000000000000373","article-title":"3D printing: current use in facial plastic and reconstructive surgery","volume":"25","author":"Hsieh","year":"2017","journal-title":"Curr Opin Otolaryngol Head Neck Surg"},{"key":"2022100812514283300_bjs11686-bib-0020","first-page":"1","article-title":"Decellularization methods for scaffold fabrication","volume":"1577","author":"Gupta","year":"2018","journal-title":"Methods Mol Biol"},{"key":"2022100812514283300_bjs11686-bib-0021","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3390\/ma9050332","article-title":"Heterogeneity of scaffold biomaterials in tissue engineering","volume":"9","author":"Edgar","year":"2016","journal-title":"Materials (Basel)"},{"key":"2022100812514283300_bjs11686-bib-0022","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.actbio.2016.11.068","article-title":"Extracellular matrix hydrogels from decellularized tissues: structure and function","volume":"49","author":"Saldin","year":"2017","journal-title":"Acta Biomater"},{"key":"2022100812514283300_bjs11686-bib-0023","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.ijporl.2016.10.012","article-title":"Tissue-engineered trachea: a review","volume":"91","author":"Law","year":"2016","journal-title":"Int J Pediatr Otorhinolaryngol"},{"key":"2022100812514283300_bjs11686-bib-0024","doi-asserted-by":"crossref","first-page":"640","DOI":"10.1177\/0022034517693606","article-title":"Decellularized human dental pulp as a scaffold for regenerative endodontics","volume":"96","author":"Song","year":"2017","journal-title":"J Dent Res"},{"key":"2022100812514283300_bjs11686-bib-0025","doi-asserted-by":"crossref","first-page":"1290","DOI":"10.1016\/j.msec.2017.03.279","article-title":"Decellularized tendon as a prospective scaffold for tendon repair","volume":"77","author":"Wang","year":"2017","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"2022100812514283300_bjs11686-bib-0026","doi-asserted-by":"crossref","first-page":"e0173040","DOI":"10.1371\/journal.pone.0173040","article-title":"Decellularized scaffold of cryopreserved rat kidney retains its recellularization potential","volume":"12","author":"Chani","year":"2017","journal-title":"PLoS One"},{"key":"2022100812514283300_bjs11686-bib-0027","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.msec.2016.10.085","article-title":"Influence of quercetin and nanohydroxyapatite modifications of decellularized goat-lung scaffold for bone regeneration","volume":"71","author":"Gupta","year":"2017","journal-title":"Mater Sci Eng C Mater Biol Appl"},{"key":"2022100812514283300_bjs11686-bib-0028","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/7651_2017_50","article-title":"Decellularized bone matrix scaffold for bone regeneration","volume":"1577","author":"Chen","year":"2018","journal-title":"Methods Mol Biol"},{"key":"2022100812514283300_bjs11686-bib-0029","doi-asserted-by":"crossref","first-page":"1277","DOI":"10.1177\/0885328217698062","article-title":"Urinary bladder extracellular matrix hydrogels and matrix-bound vesicles differentially regulate central nervous system neuron viability and axon growth and branching","volume":"31","author":"Faust","year":"2017","journal-title":"J Biomater Appl"},{"key":"2022100812514283300_bjs11686-bib-0030","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/s13287-017-0505-6","article-title":"Exploiting decellularized cochleae as scaffolds for inner ear tissue engineering","volume":"8","author":"Mellott","year":"2017","journal-title":"Stem Cell Res Ther"},{"key":"2022100812514283300_bjs11686-bib-0031","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.actbio.2017.11.046","article-title":"Decellularized heart ECM hydrogel using supercritical carbon dioxide for improved angiogenesis","volume":"67","author":"Seo","year":"2018","journal-title":"Acta Biomater"},{"key":"2022100812514283300_bjs11686-bib-0032","doi-asserted-by":"crossref","first-page":"2041731417726327","DOI":"10.1177\/2041731417726327","article-title":"Recellularization of decellularized heart valves: progress toward the tissue-engineered heart valve","volume":"8","author":"VeDepo","year":"2017","journal-title":"J Tissue Eng"},{"key":"2022100812514283300_bjs11686-bib-0033","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1007\/s10561-017-9675-9","article-title":"Preparation and evaluation of decellularized porcine carotid arteries cross-linked by genipin: the preliminary results","volume":"19","author":"Gu","year":"2018","journal-title":"Cell Tissue Bank"},{"key":"2022100812514283300_bjs11686-bib-0034","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1016\/j.biomaterials.2011.01.057","article-title":"An overview of tissue and whole organ decellularization processes","volume":"32","author":"Crapo","year":"2011","journal-title":"Biomaterials"},{"issue":"40","key":"2022100812514283300_bjs11686-bib-0035","first-page":"276","article-title":"An injectable nucleus pulposus cell-modified decellularized scaffold: biocompatible material for prevention of disc degeneration","volume":"8","author":"Shan","year":"2017","journal-title":"Oncotarget"},{"key":"2022100812514283300_bjs11686-bib-0036","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1097\/SLA.0000000000002396","article-title":"Bioengineering a human face graft: the matrix of identity","volume":"266","author":"Duisit","year":"2017","journal-title":"Ann Surg"},{"key":"2022100812514283300_bjs11686-bib-0037","doi-asserted-by":"crossref","first-page":"5488","DOI":"10.1016\/j.biomaterials.2013.03.054","article-title":"Porcine pancreas extracellular matrix as a platform for endocrine pancreas bioengineering","volume":"34","author":"Mirmalek-Sani","year":"2013","journal-title":"Biomaterials"},{"key":"2022100812514283300_bjs11686-bib-0038","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.actbio.2018.04.009","article-title":"Perfusion-decellularization of human ear grafts enables ECM-based scaffolds for auricular vascularized composite tissue engineering","volume":"73","author":"Duisit","year":"2018","journal-title":"Acta Biomater"},{"key":"2022100812514283300_bjs11686-bib-0039","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.molmed.2011.03.005","article-title":"Organ engineering based on decellularized matrix scaffolds","volume":"17","author":"Song","year":"2011","journal-title":"Trends Mol Med"},{"key":"2022100812514283300_bjs11686-bib-0040","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.actbio.2016.06.001","article-title":"Vascularization of three-dimensional engineered tissues for regenerative medicine applications","volume":"41","author":"Kim","year":"2016","journal-title":"Acta Biomater"},{"key":"2022100812514283300_bjs11686-bib-0041","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1089\/tmj.2017.0049","article-title":"3D printing in liver surgery: a systematic review","volume":"23","author":"Witowski","year":"2017","journal-title":"Telemed J E Health"},{"key":"2022100812514283300_bjs11686-bib-0042","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrcardio.2016.170","article-title":"Applications of 3D printing in cardiovascular diseases","volume":"13","author":"Giannopoulos","year":"2016","journal-title":"Nat Rev Cardiol"},{"key":"2022100812514283300_bjs11686-bib-0043","doi-asserted-by":"crossref","first-page":"024102","DOI":"10.1088\/1758-5090\/aa7279","article-title":"Current and emerging applications of 3D printing in medicine","volume":"9","author":"Liaw","year":"2017","journal-title":"Biofabrication"},{"key":"2022100812514283300_bjs11686-bib-0044","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1080\/17483107.2016.1253117","article-title":"3D-printed upper limb prostheses: a review","volume":"12","author":"Ten Kate","year":"2017","journal-title":"Disabil Rehabil Assist Technol"},{"key":"2022100812514283300_bjs11686-bib-0045","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/nbt.3413","article-title":"A 3D bioprinting system to produce human-scale tissue constructs with structural integrity","volume":"34","author":"Kang","year":"2016","journal-title":"Nat Biotechnol"},{"key":"2022100812514283300_bjs11686-bib-0046","doi-asserted-by":"crossref","first-page":"1304","DOI":"10.1089\/ten.tea.2011.0543","article-title":"Direct human cartilage repair using three-dimensional bioprinting technology","volume":"18","author":"Cui","year":"2012","journal-title":"Tissue Eng Part A"},{"key":"2022100812514283300_bjs11686-bib-0047","doi-asserted-by":"crossref","first-page":"1489","DOI":"10.1021\/acs.biomac.5b00188","article-title":"3D bioprinting human chondrocytes with nanocellulose\u2013alginate bioink for cartilage tissue engineering applications","volume":"16","author":"Markstedt","year":"2015","journal-title":"Biomacromolecules"},{"key":"2022100812514283300_bjs11686-bib-0048","doi-asserted-by":"crossref","first-page":"1286","DOI":"10.1002\/term.1682","article-title":"An additive manufacturing-based PCL\u2013alginate\u2013chondrocyte bioprinted scaffold for cartilage tissue engineering","volume":"9","author":"Kundu","year":"2015","journal-title":"J Tissue Eng Regen Med"},{"key":"2022100812514283300_bjs11686-bib-0049","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/nbt.2958","article-title":"3D bioprinting of tissues and organs","volume":"32","author":"Murphy","year":"2014","journal-title":"Nat Biotechnol"},{"key":"2022100812514283300_bjs11686-bib-0050","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1517\/14712598.2014.945414","article-title":"Skeletal tissue engineering using mesenchymal or embryonic stem cells: clinical and experimental data","volume":"14","author":"Gamie","year":"2014","journal-title":"Expert Opin Biol Ther"},{"key":"2022100812514283300_bjs11686-bib-0051","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/nature05934","article-title":"Generation of germline-competent induced pluripotent stem cells","volume":"448","author":"Okita","year":"2007","journal-title":"Nature"},{"key":"2022100812514283300_bjs11686-bib-0052","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nbt.1931","article-title":"Cell-surface markers for the isolation of pancreatic cell types derived from human embryonic stem cells","volume":"29","author":"Kelly","year":"2011","journal-title":"Nat Biotechnol"},{"key":"2022100812514283300_bjs11686-bib-0053","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/nbt1393","article-title":"Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo","volume":"26","author":"Kroon","year":"2008","journal-title":"Nat Biotechnol"},{"key":"2022100812514283300_bjs11686-bib-0054","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/s41586-019-1168-5","article-title":"Charting cellular identity during human in vitro \u03b2-cell differentiation","volume":"569","author":"Veres","year":"2019","journal-title":"Nature"},{"key":"2022100812514283300_bjs11686-bib-0055","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1073\/pnas.1222902110","article-title":"Blastocyst complementation generates exogenic pancreas in vivo in apancreatic cloned pigs","volume":"110","author":"Matsunari","year":"2013","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2022100812514283300_bjs11686-bib-0056","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1038\/s41586-018-0586-0","article-title":"Neural blastocyst complementation enables mouse forebrain organogenesis","volume":"563","author":"Chang","year":"2018","journal-title":"Nature"},{"key":"2022100812514283300_bjs11686-bib-0057","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/nature21070","article-title":"Interspecies organogenesis generates autologous functional islets","volume":"542","author":"Yamaguchi","year":"2017","journal-title":"Nature"},{"key":"2022100812514283300_bjs11686-bib-0058","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1038\/nature20573","article-title":"Stem cells and interspecies chimaeras","volume":"540","author":"Wu","year":"2016","journal-title":"Nature"},{"key":"2022100812514283300_bjs11686-bib-0059","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1097\/01.tp.0000168214.84417.7d","article-title":"Beyond operational tolerance: effect of ischemic injury on development of chronic damage in renal grafts","volume":"80","author":"Coulson","year":"2005","journal-title":"Transplantation"},{"key":"2022100812514283300_bjs11686-bib-0060","doi-asserted-by":"crossref","first-page":"1699","DOI":"10.1097\/01.TP.0000092955.28529.1E","article-title":"Quality of life in adult survivors beyond 10 years after liver, kidney, and heart transplantation","volume":"76","author":"Karam","year":"2003","journal-title":"Transplantation"},{"key":"2022100812514283300_bjs11686-bib-0061","doi-asserted-by":"crossref","first-page":"703","DOI":"10.5500\/wjt.v6.i4.703","article-title":"Quality of life 10 years after liver transplantation: the impact of graft histology","volume":"6","author":"Karam","year":"2016","journal-title":"World J Transplant"},{"key":"2022100812514283300_bjs11686-bib-0062","doi-asserted-by":"crossref","first-page":"S84","DOI":"10.1097\/01.TP.0000126933.98465.74","article-title":"Long-term effects of transplantation on quality of life","volume":"77","author":"Galbraith","year":"2004","journal-title":"Transplantation"},{"key":"2022100812514283300_bjs11686-bib-0063","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1586\/eci.10.71","article-title":"Finding the right time for weaning off immunosuppression in solid organ transplant recipients","volume":"6","author":"Orlando","year":"2010","journal-title":"Expert Rev Clin Immunol"},{"key":"2022100812514283300_bjs11686-bib-0064","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1097\/SLA.0b013e3181f3efb0","article-title":"Clinical operational tolerance after renal transplantation","volume":"252","author":"Orlando","year":"2010","journal-title":"Ann Surg"},{"key":"2022100812514283300_bjs11686-bib-0065","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1016\/j.jhep.2009.03.006","article-title":"Operational tolerance after liver transplantation","volume":"50","author":"Orlando","year":"2009","journal-title":"J Hepatol"},{"key":"2022100812514283300_bjs11686-bib-0066","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.trim.2006.09.021","article-title":"Operational tolerance in clinical liver transplantation: emerging developments","volume":"17","author":"Tisone","year":"2007","journal-title":"Transpl Immunol"},{"key":"2022100812514283300_bjs11686-bib-0067","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1089\/tea.2007.0145","article-title":"Biocompatibility and potential of acellular human amniotic membrane to support the attachment and proliferation of allogeneic cells","volume":"14","author":"Wilshaw","year":"2008","journal-title":"Tissue Eng Part A"},{"key":"2022100812514283300_bjs11686-bib-0068","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1111\/tri.13068","article-title":"Regenerative immunology: the immunological reaction to biomaterials","volume":"30","author":"Cravedi","year":"2017","journal-title":"Transpl Int"},{"key":"2022100812514283300_bjs11686-bib-0069","doi-asserted-by":"crossref","first-page":"4571","DOI":"10.1074\/jbc.R113.509588","article-title":"The potential for immunogenicity of autologous induced pluripotent stem cell-derived therapies","volume":"289","author":"Scheiner","year":"2014","journal-title":"J Biol Chem"},{"key":"2022100812514283300_bjs11686-bib-0070","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1038\/nbt.2960","article-title":"Overcoming immunological barriers in regenerative medicine","volume":"32","author":"Zakrzewski","year":"2014","journal-title":"Nat Biotechnol"},{"key":"2022100812514283300_bjs11686-bib-0071","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1097\/TP.0000000000002455","article-title":"Potentiating renal regeneration using mesenchymal stem cells","volume":"103","author":"Brasile","year":"2019","journal-title":"Transplantation"},{"key":"2022100812514283300_bjs11686-bib-0072","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1038\/s41536-017-0008-1","article-title":"The protein tyrosine phosphatase 1B inhibitor MSI-1436 stimulates regeneration of heart and multiple other tissues","volume":"2","author":"Smith","year":"2017","journal-title":"NPJ Regenerat Med"},{"key":"2022100812514283300_bjs11686-bib-0073","doi-asserted-by":"crossref","first-page":"4ra9","DOI":"10.1126\/scitranslmed.3000266","article-title":"Functional repair of human donor lungs by IL-10 gene therapy","volume":"1","author":"Cypel","year":"2009","journal-title":"Sci Transl Med"},{"key":"2022100812514283300_bjs11686-bib-0074","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1097\/SLA.0b013e31829c79cf","article-title":"Organ bioengineering and regeneration as the new Holy Grail for organ transplantation","volume":"258","author":"Orlando","year":"2013","journal-title":"Ann Surg"},{"key":"2022100812514283300_bjs11686-bib-0075","volume-title":"President's Message","author":"Cell Transplant and Regenerative Medicine Society"},{"key":"2022100812514283300_bjs11686-bib-0076","volume-title":"Transplant Regenerative Medicine Community of Practice (TRM COP)","author":"American Society of Transplantation"},{"key":"2022100812514283300_bjs11686-bib-0077","author":"European Society for Organ Transplantation\/European Cell Therapy and Organ Regeneration Section"}],"container-title":["British Journal of Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.11686","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/107\/7\/793\/46378998\/bjs11686.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/107\/7\/793\/46378998\/bjs11686.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,10,8]],"date-time":"2022-10-08T13:23:16Z","timestamp":1665235396000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/107\/7\/793\/6094029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,28]]},"references-count":77,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2020,5,28]]},"published-print":{"date-parts":[[2020,5,28]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.11686","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,6]]},"published":{"date-parts":[[2020,5,28]]}}}