{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,20]],"date-time":"2025-10-20T17:38:16Z","timestamp":1760981896609},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1973,1,1]],"date-time":"1973-01-01T00:00:00Z","timestamp":94694400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"British Empire Cancer Campaign"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1973,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Thirty-one cases of carcinoma of the ampulla of Vater and duodenum have been classified on the basis of pathological criteria.<\/jats:p>\n               <jats:p>Two types of tumour were discernible. Nine were polypoid papillary adenocarcinomas occurring at the ampulla of Vater; 19 were adenocarcinomas without a papillary pattern, of which 4 were duodenal tumours and 15 were ampullary. There were 3 ampullary tumours of mixed type. The carcinomas without a papillary structure were more invasive, more often associated with abdominal pain, more frequently misdiagnosed, and were associated with a higher mortality-rate.<\/jats:p>\n               <jats:p>The data were insufficient to draw firm conclusions as to the prognosis but the clinical behaviour was related to the pathology of the tumours.<\/jats:p>\n               <jats:p>Lesions in the ampullary region were associated with jaundice which was often intermittent. Lesions outside the ampullary area presented early with vomiting of pyloric type but without jaundice.<\/jats:p>\n               <jats:p>The importance of a high index of suspicion in dealing with these lesions and the value of barium-meal examinations are emphasized.<\/jats:p>\n               <jats:p>It is noted that pancreaticoduodenectomy for ampullary carcinoma has a mortality of less than 25 per cent if performed by an experienced surgeon and can be considerably lower in clinics specializing in this condition.<\/jats:p>\n               <jats:p>We suggest that the pathological classification of these tumours used in this paper may form the basis for further investigations into the diagnostic and prognostic problems which these tumours present.<\/jats:p>\n               <jats:p>This classification of ampullary tumours is a factor to be considered in assessing the indications for pancreaticoduodenectomy.<\/jats:p>","DOI":"10.1002\/bjs.1800600109","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T11:20:32Z","timestamp":1172834432000},"page":"33-40","source":"Crossref","is-referenced-by-count":39,"title":["Carcinoma of the ampulla of Vater and duodenum"],"prefix":"10.1093","volume":"60","author":[{"given":"L H","family":"Blumgart","sequence":"first","affiliation":[{"name":"Sheffield Royal Infirmary and Department of Pathology, University of Sheffield"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Kennedy","sequence":"additional","affiliation":[{"name":"Sheffield Royal Infirmary and Department of Pathology, University of Sheffield"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1973,1,1]]},"reference":[{"key":"2024092613373372200_bib1","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1097\/00000658-195406000-00015","volume":"139","author":"Astler","year":"1954","journal-title":"Ann. 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