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Four out of 5 cases had bilateral lobular carcinoma in situ and 2 patients had bilateral infiltrating carcinomas. The premalignant nature of lobular carcinoma in situ is not proven but is likely. It is suggested that the evidence supports previously expressed views that a histological diagnosis of lobular carcinoma in situ merits mastectomy and a large contralateral biopsy in the first instance.<\/jats:p>","DOI":"10.1002\/bjs.1800600708","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T11:53:22Z","timestamp":1172836402000},"page":"527-529","source":"Crossref","is-referenced-by-count":1,"title":["Lobular carcinoma in situ of the breast"],"prefix":"10.1093","volume":"60","author":[{"given":"R A A","family":"Macaulay","sequence":"first","affiliation":[{"name":"Department of Pathology, University of Cambridge"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"Mitchinson","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Cambridge"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1973,7,1]]},"reference":[{"key":"2024092709354491400_bib1","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/1097-0142(197002)25:2<468::AID-CNCR2820250226>3.0.CO;2-0","volume":"25","author":"Farrow","year":"1970","journal-title":"Cancer, N. 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