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Essentially the changes which occurred were those which are seen in healing by fibrosis, except that in many areas of adhesions numerous eosinophils were observed by electron microscopy. In areas where eosinophils were numerous little proliferation of fibro-blasts was seen. Conversely in sites where fibroplasia and collagen formation were well advanced no eosinophils were seen. The role of the eosinophil in the development of adhesions is discussed and it is suggested that the presence of eosinophiis with their associated anti-histamine activity may hold in check the proliferation of fibroblasts while a new mesothelium is formed and thus prevent adhesion formation.<\/jats:p>","DOI":"10.1002\/bjs.1800610406","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T12:04:07Z","timestamp":1172837047000},"page":"274-280","source":"Crossref","is-referenced-by-count":134,"title":["Observations on the pathogenesis of peritoneal adhesions: a light and electron microscopical study"],"prefix":"10.1093","volume":"61","author":[{"given":"D W","family":"Milligan","sequence":"first","affiliation":[{"name":"Department of Anatomy, University of Leeds"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A T","family":"Raftery","sequence":"additional","affiliation":[{"name":"Department of Anatomy, University of Leeds"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1974,4,1]]},"reference":[{"key":"2024092618175277600_bib1","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1002\/path.1700780111","article-title":"Eosinophil leucocytes and their reactions to histamine and 5-hydroxytryptamine","volume":"78","author":"Archer","year":"1959","journal-title":"J. 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