{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T04:32:38Z","timestamp":1727411558132},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[1974,9,1]],"date-time":"1974-09-01T00:00:00Z","timestamp":147225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1974,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Acid in the duodenum is known to inhibit gastric secretion in man but whether this response is a humoral or a vagal phenomenon is unknown. If a vagal reflex is involved then selective and highly selective vagotomy, by preserving the duodenal nerve supply, could offer advantages over truncal division. This study was designed to investigate this claim.<\/jats:p>\n               <jats:p>The effect of intraduodenal hydrochloric acid on pentagnstrin-stimulated gastric secretion was stimulated in 17 control subjects, 32 preoperative duodenal ulcer patients and 28 vagotomized patients (16 truncal vagotomy and pyloroplasty; 6 selective vagotomy and pyloroplasty; 6 highly selective vagotomy). Inhibition of acid output occurred in 15 control subjects, and the mean inhibition for the group was 2.68 + 0.39 mEq\/10 minutes (P &amp;lt; 0.001). Inhibition occurred in 22 duodenal ulcer patients, and the mean reduction in acid output for the entire group was 2.26 \u00b1 0.46 mEq\/l0 minutes (P &amp;lt; 0.001). Intraduodenal acid failed to produce a response in the vagotomized patients irrespective of the presence or absence of a duodenal nerve supply.<\/jats:p>\n               <jats:p>These results suggest that gastric secretory inhibition by intraduodenal acid is a vagal phenomenon in man; selective and highly selective vagotomy do not appear to carry any particular advantage over truncal section in terms of preserving this response.<\/jats:p>","DOI":"10.1002\/bjs.1800610906","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T12:07:33Z","timestamp":1172837253000},"page":"698-704","source":"Crossref","is-referenced-by-count":5,"title":["The effect of vagotomy on the inhibition of gastric secretion by intraduodenal acid"],"prefix":"10.1093","volume":"61","author":[{"given":"A S","family":"Ward","sequence":"first","affiliation":[{"name":"University Surgical Unit, Royal Infirmary , Sheffield"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1974,9,1]]},"reference":[{"key":"2024092618561407800_bib1","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1111\/j.1748-1716.1960.tb01927.x","article-title":"Inhibitory effects of acid in antrum-duodenum on fasting gastric secretion in Pavlov and Heidenhain pouch dogs","volume":"49","author":"Anderson","year":"1960","journal-title":"Acta Physiol. 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