{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T04:33:42Z","timestamp":1727411622333},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[1975,7,1]],"date-time":"1975-07-01T00:00:00Z","timestamp":173404800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1975,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Infection with Gram-negative bacteria is frequently the cause of death in human liver transplantation. In experimental liver transplantation in mongrel dogs we detected Gram-negative septicaemia in 73 per cent of our first 15 cases; maximal survival was 26 days.<\/jats:p>\n               <jats:p>In a second series of 27 orthotopic liver transplantations in tissue-typed littermate dogs and littermate pigs the standard surgical technique and aftercare were changed with regard to four factors: an end-to-end common bile duct anastomosis was made instead of a gallbladder to duodenum anastomosis; the continuous postoperative bacteriostatic antibiotic therapy was changed to a single 2-day course of bactericidal antibiotics; preoperative selective bowel decontamination combined with postoperative protective isolation was introduced; the dosage of azathioprine used for immuno-suppression was reduced.<\/jats:p>\n               <jats:p>Infectious complications decreased markedly to 8 per cent, with survival beyond 1 year in 37 per cent of the animals. Therefore under experimental conditions Gram-negative septicaemia can be prevented in liver transplantation; whether all the factors cited above are important in this regard remains to be determined.<\/jats:p>","DOI":"10.1002\/bjs.1800620703","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T12:24:25Z","timestamp":1172838265000},"page":"513-517","source":"Crossref","is-referenced-by-count":1,"title":["Orthotopic liver transplantation: An experimental study on the prevention of infections with Gram-negative organisms"],"prefix":"10.1093","volume":"62","author":[{"given":"S W","family":"Schalm","sequence":"first","affiliation":[{"name":"Department of Internal Medicine, Surgery and Anaesthesiology, University Hospital , Leiden,","place":["Holland"]},{"name":"Radio-biological Institute TNO , Rijswijk,","place":["Holland"]},{"name":"Department of Cytology and Histology, University of Nijmegen ,","place":["Holland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D T","family":"Popescu","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Surgery and Anaesthesiology, University Hospital , Leiden,","place":["Holland"]},{"name":"Radio-biological Institute TNO , Rijswijk,","place":["Holland"]},{"name":"Department of Cytology and Histology, University of Nijmegen ,","place":["Holland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Van Der Waay","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Surgery and Anaesthesiology, University Hospital , Leiden,","place":["Holland"]},{"name":"Radio-biological Institute TNO , Rijswijk,","place":["Holland"]},{"name":"Department of Cytology and Histology, University of Nijmegen ,","place":["Holland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A F","family":"Krom","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Surgery and Anaesthesiology, University Hospital , Leiden,","place":["Holland"]},{"name":"Radio-biological Institute TNO , Rijswijk,","place":["Holland"]},{"name":"Department of Cytology and Histology, University of Nijmegen ,","place":["Holland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W D H","family":"Hendriks","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Surgery and Anaesthesiology, University Hospital , Leiden,","place":["Holland"]},{"name":"Radio-biological Institute TNO , Rijswijk,","place":["Holland"]},{"name":"Department of Cytology and Histology, University of Nijmegen ,","place":["Holland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J L","family":"Terpstra","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Surgery and Anaesthesiology, University Hospital , Leiden,","place":["Holland"]},{"name":"Radio-biological Institute TNO , Rijswijk,","place":["Holland"]},{"name":"Department of Cytology and Histology, University of Nijmegen ,","place":["Holland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Jerusalem","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Surgery and Anaesthesiology, University Hospital , Leiden,","place":["Holland"]},{"name":"Radio-biological Institute TNO , Rijswijk,","place":["Holland"]},{"name":"Department of Cytology and Histology, University of Nijmegen ,","place":["Holland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1975,7,1]]},"reference":[{"key":"2024092619334776900_bib1","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/0022-4804(67)90080-7","article-title":"Replantation of the liver in dogs","volume":"7","author":"Alican","year":"1967","journal-title":"J. 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