{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T04:40:18Z","timestamp":1771562418026,"version":"3.50.1"},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[1976,7,1]],"date-time":"1976-07-01T00:00:00Z","timestamp":205027200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1976,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Sixty-two patients were admitted to a prospective randomized controlled trial 10 investigate the influence of a prophylactic antibiotic, lincomycin, on anaerobic sepsis following bowel surgery. The incidence of postoperative sepsis was reduced from 45 to 18 per cent (P &amp;lt; 0\u00b7025). Wound infections were reduced from 38 to 12 per cent (P &amp;lt; 0\u00b705). Intra-abdominal or pelvic abscess occurred in 1 of the treated group compared with 3 controls. Septicaemia occurred after operation in 1 patient receiving lincomycin and in 3 of the controls; in 2 of the latter, pure growths of bacteroides were isolated from the blood cultures and 1 of these patients died. Although Iincomycin had no influence on the number of patients who developed aerobic postoperative infections, there was a significant reduction in the incidence of sepsis due to bacteroides, which occurred in 10 of the control group compared with 1 in the lincomycin group (P &amp;lt; 0\u00b7005). No patients developed complications attributable to lincomycin, such as pseudomembranous colitis.<\/jats:p>\n               <jats:p>These data indicate that the genus Bacteroides are important pathogenic organisms and are responsible for postoperative morbidity. Furthermore, anaerobic sepsis can be reduced by appropriate prophylactic antibiotics.<\/jats:p>","DOI":"10.1002\/bjs.1800630711","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T13:32:45Z","timestamp":1172842365000},"page":"538-541","source":"Crossref","is-referenced-by-count":50,"title":["Prophylaxis against anaerobic sepsis in bowel surgery"],"prefix":"10.1093","volume":"63","author":[{"given":"M R B","family":"Keighley","sequence":"first","affiliation":[{"name":"The General Hospital , Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A R","family":"Crapp","sequence":"additional","affiliation":[{"name":"The General Hospital , Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D W","family":"Burdon","sequence":"additional","affiliation":[{"name":"The General Hospital , Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W T","family":"Cooke","sequence":"additional","affiliation":[{"name":"The General Hospital , Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Alexander-Williams","sequence":"additional","affiliation":[{"name":"The General Hospital , Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1976,7,1]]},"reference":[{"key":"2024101409075324900_bib1","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/bjs.1800580504","article-title":"Post- operative wound infection: a computer analysis","volume":"58","author":"Davidson","year":"1971","journal-title":"Br. 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