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In a controlled prospective trial, 18 of 22 patients (82 per cent) had taken drugs known to be potentially harmful to the stomach. Aspirin was the drug mainly used. Thirteen of 22 patients had taken the drugs within 12 hours of the perforation, usually because of symptoms not related to the gastro-intestinal tract. Drug consumption and perforation of pre-pyloric ulcers were most closely associated; the latter applies particularly to female patients, who either had only a short history of upper gastro-intenstinal dyspepsia or were asymptomatic.<\/jats:p>","DOI":"10.1002\/bjs.1800640406","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T14:08:11Z","timestamp":1172844491000},"page":"247-249","source":"Crossref","is-referenced-by-count":34,"title":["Drug consumption before perforation of peptic ulcer"],"prefix":"10.1093","volume":"64","author":[{"given":"T Glarborg","family":"J\u00f8rgensen","sequence":"first","affiliation":[{"name":"Institute of Experimental Research in Surgery, University of Copenhagen ,","place":["Denmark"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1977,4,1]]},"reference":[{"key":"2024101718411474500_bib1","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/S0016-5085(19)35890-1","article-title":"Influence of some of the salicyl compounds (and alcoholic beverages) on the natural history of peptic ulcer","volume":"31","author":"Brown","year":"1956","journal-title":"Gastroenterology"},{"key":"2024101718411474500_bib2","first-page":"1097","article-title":"Les ulc\u00e8res gastro-duodenaux de la corticoth\u00e9rapie","volume":"55","author":"Cachin","year":"1966","journal-title":"Arch. 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