{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T01:36:19Z","timestamp":1759541779794},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1978,2,1]],"date-time":"1978-02-01T00:00:00Z","timestamp":255139200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1978,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The release of antral gastrin has been examined in human subjects by infusing saline and albumin into their stomachs. Immunoreactive gastrin (IRG) was present in fasting serum but not in fasting gastric juice. Intragastric infusions of saline and albumin induced small but significant (P &amp;lt; 0.05) rises in the serum concentrations of IRG. There was no significant difference between the magnitude of the serum gastrin responses to these two stimuli. The stimuli induced a rise in the luminal concentration of IRG which was sixfold greater than that in the serum concentration of IRG. The response to albumin was significantly greater than the response to saline (P &amp;lt; 0.05). The IRG in gastric juice was chromatographically similar to heptadecapeptide gastrin. The stimuli also released IRG in patients with duodenal ulcers. The magnitude of the release into serum and gastric juice in these patients was significantly reduced by antrectomy (P &amp;lt; 0.05).<\/jats:p>","DOI":"10.1002\/bjs.1800650214","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T16:29:10Z","timestamp":1172852950000},"page":"118-120","source":"Crossref","is-referenced-by-count":8,"title":["<i>In vivo<\/i> release of gastrin into human gastric juice"],"prefix":"10.1093","volume":"65","author":[{"given":"N F","family":"Knight","sequence":"first","affiliation":[{"name":"Departments of Surgery and Medicine, Endocrine and Diabetes Research Group, University of Cape Town Medical School, and Groote Schuur Hospital , Cape Town"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R G","family":"Fiddian-Green","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Medicine, Endocrine and Diabetes Research Group, University of Cape Town Medical School, and Groote Schuur Hospital , Cape Town"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A I","family":"Vinik","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Medicine, Endocrine and Diabetes Research Group, University of Cape Town Medical School, and Groote Schuur Hospital , Cape Town"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1978,2,1]]},"reference":[{"key":"2024092619580412300_bib1","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/S0016-5085(19)33932-0","article-title":"The effect of secretin glucagon and duodenal acidification on pepsin secretion in man","volume":"57","author":"Brooks","year":"1969","journal-title":"Gastroenterology"},{"key":"2024092619580412300_bib2","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1016\/S0016-5085(19)32459-X","article-title":"Chemicals bathing the oxyntic gland area stimulate gastric acid secretion","volume":"69","author":"Debas","year":"1975","journal-title":"Gastroenterology"},{"key":"2024092619580412300_bib3","first-page":"A103\/961","article-title":"In vitro release of gastrin from oriented sheets of human antral mucosa","volume":"70","author":"Fiddian-Green","year":"1976","journal-title":"Gastroenterology"},{"key":"2024092619580412300_bib4","first-page":"A136\/1159","article-title":"Regulation of gastrin release into human gastric juice","volume":"72","author":"Fiddian-Green","year":"1977","journal-title":"Gastroenterology"},{"key":"2024092619580412300_bib5","first-page":"352","article-title":"The presence of gastrin in fasting and stimulated gastric juice of man","volume":"72","author":"Jordan","year":"1972","journal-title":"Surgery"},{"key":"2024092619580412300_bib6","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/S0140-6736(75)90815-6","article-title":"Absorption of pentagastrin from the gastrointestinal tract in man","volume":"2","author":"Morrell","year":"1975","journal-title":"Lancet"},{"key":"2024092619580412300_bib7","volume-title":"Statistical Methods","author":"Snedecor","year":"1967","edition":"6th"},{"key":"2024092619580412300_bib8","first-page":"345","article-title":"Effect of histamine on immunoreactive gastrin in gastric juice and serum","volume":"77","author":"Stadil","year":"1975","journal-title":"Surgery"},{"key":"2024092619580412300_bib9","first-page":"292","article-title":"Artifacts in the radioimmunoassay of peptide hormones in gastric and duodenal secretions","volume":"87","author":"Strauss","year":"1976","journal-title":"J. Lab. Clin. Med"},{"key":"2024092619580412300_bib10","first-page":"255","article-title":"Gastrins in human antrum, duodenum and peripheral circulation","volume":"49","author":"Vinik","year":"1975","journal-title":"S, Afr. Med. J."}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800650214","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/65\/2\/118\/59360966\/bjs1800650214.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/65\/2\/118\/59360966\/bjs1800650214.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,26]],"date-time":"2024-09-26T19:58:12Z","timestamp":1727380692000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/65\/2\/118\/6192939"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,2,1]]},"references-count":10,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1978,2,1]]},"published-print":{"date-parts":[[1978,2,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800650214","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"type":"print","value":"0007-1323"},{"type":"electronic","value":"1365-2168"}],"subject":[],"published-other":{"date-parts":[[1978,2]]},"published":{"date-parts":[[1978,2,1]]}}}