{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T17:37:21Z","timestamp":1773769041797,"version":"3.50.1"},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[1978,9,1]],"date-time":"1978-09-01T00:00:00Z","timestamp":273456000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1978,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A study of 120 patients undergoing elective colorectal operations has investigated the effect of adding oral neomycin and metronidazole to bowel preparation in a double-blind randomized controlled trial. Comparisons have also been made between a standard mechanical preparation and the use of an elemental diet. The addition of neomycin and metronidazole to bowel preparation significantly reduced the rate of wound sepsis (P&amp;lt;0.01), septicaemia (P&amp;lt;0.02) and anastomotic dehiscence (P&amp;lt;0.02); anaerobic infections were abolished and there was a significant reduction in the incidence of aerobic Gram-negative infections. Elemental diets were shown to have no advantage over mechanical preparation.<\/jats:p>","DOI":"10.1002\/bjs.1800650902","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T16:53:01Z","timestamp":1172854381000},"page":"597-600","source":"Crossref","is-referenced-by-count":119,"title":["Randomized multicentre trial of oral bowel preparation and antimicrobials for elective colorectal operations"],"prefix":"10.1093","volume":"65","author":[{"given":"D M","family":"Matheson","sequence":"first","affiliation":[{"name":"The General, Selly Oak and East Birmingham Hospitals , Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y","family":"Arabi","sequence":"additional","affiliation":[{"name":"The General, Selly Oak and East Birmingham Hospitals , Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Baxter-Smith","sequence":"additional","affiliation":[{"name":"The General, Selly Oak and East Birmingham Hospitals , Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Alexander-Williams","sequence":"additional","affiliation":[{"name":"The General, Selly Oak and East Birmingham Hospitals , Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M R B","family":"Keighley","sequence":"additional","affiliation":[{"name":"The General, Selly Oak and East Birmingham Hospitals , Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1978,9,1]]},"reference":[{"key":"2024092619573481700_bib1","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/S0016-5085(19)32289-9","article-title":"Bacteriological studies in patients with antibiotic-associated pseud omembranous colitis","volume":"73","author":"Allen","year":"1977","journal-title":"Gastroenterology"},{"key":"2024092619573481700_bib2","first-page":"831","article-title":"Influence of bowel preparation and antimicrobials on colonic microflora","volume":"64","author":"Arabi","year":"1977","journal-title":"Br. J. Surg."},{"key":"2024092619573481700_bib3","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1002\/bjs.1800600512","article-title":"Postoperative wound infection in colonic and rectal surgery","volume":"60","author":"Burton","year":"1973","journal-title":"Br. J. Surg."},{"key":"2024092619573481700_bib4","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1097\/00000658-197709000-00003","article-title":"Preoperative antibiotics reduce septic complications of colon operations","volume":"186","author":"Clarke","year":"1977","journal-title":"Ann. Surg."},{"key":"2024092619573481700_bib5","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1002\/bjs.1800560911","article-title":"The place of antibiotics in colonic surgery","volume":"56","author":"Everett","year":"1969","journal-title":"Br. J. Surg."},{"key":"2024092619573481700_bib6","first-page":"703","article-title":"Preoperative preparation of the colon with an elemental diet","volume":"745","author":"Glotzer","year":"1973","journal-title":"Surgery"},{"key":"2024092619573481700_bib7","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1016\/S0140-6736(75)90289-5","article-title":"Prophylactic oral antimicrobial agents in elective colonic surgery","volume":"2","author":"Goldring","year":"1975","journal-title":"Lancet"},{"key":"2024092619573481700_bib8","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1002\/bjs.1800631221","article-title":"An elemental diet as preoperative preparation of the colon","volume":"63","author":"Gurry","year":"1976","journal-title":"Br. J. Surg."},{"key":"2024092619573481700_bib9","first-page":"347","article-title":"Asepsis in large bowel surgery","volume":"51","author":"Hughes","year":"1972","journal-title":"Ann. R. Coll. Surg. Engl."},{"key":"2024092619573481700_bib10","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1002\/bjs.1800600612","article-title":"Aetiology of disruption of intestinal anastomosis","volume":"60","author":"Irvin","year":"1973","journal-title":"Br. J. Surg."},{"key":"2024092619573481700_bib11","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1001\/archsurg.1974.01350250024006","article-title":"Oral elemental diet: a new bowel preparation","volume":"108","author":"Johnson","year":"1974","journal-title":"Arch. Surg."},{"key":"2024092619573481700_bib12","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.1.6114.675","article-title":"Diagnosis of pseudomembranous colitis","volume-title":"Br. Med. J","author":"Kappas","year":"1978"},{"key":"2024092619573481700_bib13","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/bjs.1800640505","article-title":"Prevention of wound sepsis in gastrointestinal surgery","volume":"64","author":"Keighley","year":"1977","journal-title":"Br. J. Surg."},{"key":"2024092619573481700_bib14","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1177\/003693307602100211","article-title":"Short term prophylaxis with tobramycin and lincomycin in bowel surgery","volume":"21","author":"Keighley","year":"1976","journal-title":"Scot. Med. J."},{"key":"2024092619573481700_bib15","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1002\/bjs.1800630711","article-title":"Prophylaxis against anaerobic sepsis in bowel surgery","volume":"63","author":"Keighley","year":"1976","journal-title":"Br. J. Surg."},{"key":"2024092619573481700_bib16","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1136\/bmj.1.6071.1246","article-title":"Undescribed toxin in pseudomembranous colitis","volume":"1","author":"Larson","year":"1977","journal-title":"Br. Med. J."},{"key":"2024092619573481700_bib17","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0002-9610(76)90419-0","article-title":"Effects of prophylactic antibiotics on colonic healing","volume":"131","author":"Leveen","year":"1976","journal-title":"Am. J. Surg."},{"key":"2024092619573481700_bib18","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1097\/00000658-197208000-00019","article-title":"Efficacy of pre-operative antimicrobial preparation of the colon","volume":"176","author":"Nichols","year":"1972","journal-title":"Ann. Surg."},{"key":"2024092619573481700_bib19","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/S0140-6736(77)90547-5","article-title":"Antibiotic induced colitis: implication of a toxin neutralised by Clostridium sordellii antitoxin","volume":"2","author":"Rifkin","year":"1977","journal-title":"Lancer"},{"key":"2024092619573481700_bib20","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1002\/bjs.1800560816","article-title":"A second clinical trial to compare two methods of preoperative preparation of the large bowel","volume":"56","author":"Sellwood","year":"1969","journal-title":"Br. J. Surg."},{"key":"2024092619573481700_bib21","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1097\/00000658-197410000-00021","article-title":"Effect of preoperative antibiotic regimen on development of infection after intestinal surgery. Prospective randomised double blind study","volume":"180","author":"Washington","year":"1974","journal-title":"Ann. Surg."},{"key":"2024092619573481700_bib22","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1136\/bmj.1.6061.607","article-title":"Metronidazole in prevention and treatment of Bacteroides infections in elective colonic surgery","volume":"1","author":"Willis","year":"1977","journal-title":"Br. Med. J."}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800650902","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/65\/9\/597\/59360934\/bjs1800650902.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/65\/9\/597\/59360934\/bjs1800650902.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,14]],"date-time":"2025-01-14T13:44:30Z","timestamp":1736862270000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/65\/9\/597\/6186886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,9,1]]},"references-count":22,"journal-issue":{"issue":"9","published-online":{"date-parts":[[1978,9,1]]},"published-print":{"date-parts":[[1978,9,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800650902","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1978,9]]},"published":{"date-parts":[[1978,9,1]]}}}