{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T13:09:17Z","timestamp":1760015357105},"reference-count":23,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1981,2,1]],"date-time":"1981-02-01T00:00:00Z","timestamp":349833600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The present trend towards a more aggressive operative policy in acute cholecystitis has led to a search for more accurate methods of diagnosis. A possible contender in this field is hepatobiliary isotope scanning.<\/jats:p>\n               <jats:p>Ninety-nine patients with right-sided upper abdominal pain were studied after the intravenous injection of 99Tcm-pyridoxylideneglutamate. In addition, contrast radiology was performed in 87 of these. Subsequently 23 were shown to have acute cholecystitis, 45 to have other gallbladder disease and 31 to have no evidence of cholecystic pathology.<\/jats:p>\n               <jats:p>Isotope scanning was found to be reliable when negative at excluding acute cholecystitis (predictive value 100 per cent) and when positive at confirming gallbladder disease (predictive value 100 per cent). In these respects it compared favourably with contrast radiology (corresponding predictive values 80 per cent and 94 per cent) but was greatly inferior for the exclusion of cholelithiasis.<\/jats:p>\n               <jats:p>A practical method of scanning for routine clinical use is outlined and it is suggested that the method may be clinically useful as a first investigation in those patients presenting with acute right-sided upper abdominal pain. It may also be helpful in confirming pathology in a nonfunctioning gallbladder on oral cholecystography. When the isotope scan is negative (normal) contrast radiology is still required to exclude cholelithiasis. By a combination of the two techniques the correct diagnosis was arrived at in each of the 99 patients studied, suggesting that the methods may have complementary roles.<\/jats:p>","DOI":"10.1002\/bjs.1800680208","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T20:36:41Z","timestamp":1172867801000},"page":"85-90","source":"Crossref","is-referenced-by-count":12,"title":["The place of hepatobiliary isotope scanning in the diagnosis of gallbladder disease"],"prefix":"10.1093","volume":"68","author":[{"given":"Andrew W","family":"Hall","sequence":"first","affiliation":[{"name":"Departments of Surgery, Universities of Leicester and Dundee, and the Department of Medical Physics, University of Dundee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M L","family":"Wisbey","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Universities of Leicester and Dundee, and the Department of Medical Physics, University of Dundee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F","family":"Hutchinson","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Universities of Leicester and Dundee, and the Department of Medical Physics, University of Dundee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert A B","family":"Wood","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Universities of Leicester and Dundee, and the Department of Medical Physics, University of Dundee"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alfred","family":"Cuschieri","sequence":"additional","affiliation":[{"name":"Departments of Surgery, Universities of Leicester and Dundee, and the Department of Medical Physics, University of Dundee"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1981,2,1]]},"reference":[{"key":"2024092713410453700_bib1","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0002-9610(70)80133-7","article-title":"Early versus delayed operation for acute cholecystitis","volume":"120","author":"van der Linden","year":"1970","journal-title":"Am. J. Surg."},{"key":"2024092713410453700_bib2","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1002\/bjs.1800621025","article-title":"Controlled clinical trial comparing early with interval cholecystectomy for acute cholecystis","volume":"62","author":"McArthur","year":"1975","journal-title":"Br. J. Surg."},{"key":"2024092713410453700_bib3","doi-asserted-by":"crossref","first-page":"1032","DOI":"10.1002\/bjs.1800531206","article-title":"Management of acute cholecystitis","volume":"53","author":"Essenhigh","year":"1966","journal-title":"Br. J. Surg."},{"key":"2024092713410453700_bib4","doi-asserted-by":"crossref","first-page":"318","DOI":"10.7326\/0003-4819-82-3-318","article-title":"A test for patency of the cystic duct in acute cholecystitis","volume":"82","author":"Eikman","year":"1975","journal-title":"Ann. Intern. Med."},{"key":"2024092713410453700_bib5","first-page":"720","article-title":"Technetium 99mpyridoxylideneglutamate: a new hepatobiliary radiopharmaceutical. I. Experimental aspects","volume":"16","author":"Baker","year":"1975","journal-title":"J. Nucl. Med."},{"key":"2024092713410453700_bib6","first-page":"728","article-title":"Technetium 99mpyridoxylideneglutamate: a new hepatobiliary radiopharmaceutical. II. Clinical aspects","volume":"16","author":"Ronai","year":"1975","journal-title":"J. Nucl. Med."},{"key":"2024092713410453700_bib7","first-page":"361","article-title":"A prospective, comparative trial of hepatobiliary scanning and contrast radiology in the diagnosis of acute cholecystitis","volume":"65","author":"Hall","year":"1978","journal-title":"Br. J. Surg."},{"key":"2024092713410453700_bib8","first-page":"449","article-title":"The use of scintiscanning for the diagnosis of gallbladder disease; a comparative trial with contrast radiology","volume":"19","author":"Hall","year":"1978","journal-title":"Gut"},{"key":"2024092713410453700_bib9","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1056\/NEJM196605262742104","article-title":"Predictive value of a single diagnostic test in unselected populations","volume":"274","author":"Vecchio","year":"1966","journal-title":"N. Engl. J. Med."},{"key":"2024092713410453700_bib10","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/0002-9610(77)90204-5","article-title":"Hepatobiliary scanning using 99mTc-pyridoxylideneglutamate","volume":"133","author":"Matolo","year":"1977","journal-title":"Am. J. Surg."},{"key":"2024092713410453700_bib11","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1148\/126.2.467","article-title":"Diagnosis of hepatobiliary disease by 99mTc-HIDA cholescintigraphy","volume":"126","author":"Rosenthal","year":"1978","journal-title":"Radiology"},{"key":"2024092713410453700_bib12","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1259\/0007-1285-51-611-858","article-title":"Hepatobiliary imaging: a comparison of 99mTc-dihydrothioctic acid and 99mTc-pyridoxylideneglutamate in the non-jaundiced patient","volume":"51","author":"Jenner","year":"1978","journal-title":"Br. J. Radiol."},{"key":"2024092713410453700_bib13","first-page":"488","article-title":"Hepatobiliary radiopharmaceuticals: defining their clinical role will be a galling experience","volume":"18","author":"Ronai","year":"1977","journal-title":"J. Nucl. Med."},{"key":"2024092713410453700_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1148\/112.1.1","article-title":"The nonopacified gallbladder on oral cholecystography","volume":"112","author":"Mujahed","year":"1974","journal-title":"Radiology"},{"key":"2024092713410453700_bib15","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1002\/bjs.1800620721","article-title":"The negative cholecystogram in gallbladder disease","volume":"62","author":"Reid","year":"1975","journal-title":"Br. J. Surg."},{"key":"2024092713410453700_bib16","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1016\/S0002-9610(70)80169-6","article-title":"Intravenous cholangiography in the diagnosis of acute cholecystitis","volume":"120","author":"Chang","year":"1970","journal-title":"Am. J. Surg."},{"key":"2024092713410453700_bib17","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/0002-9610(73)90007-X","article-title":"Emergency intravenous cholangiography in patients with acute abdominal pain","volume":"125","author":"Thorpe","year":"1973","journal-title":"Am. J. Surg."},{"key":"2024092713410453700_bib18","doi-asserted-by":"crossref","first-page":"235","DOI":"10.2214\/ajr.110.2.235","article-title":"Intravenous cholangiography with intact gallbladder","volume":"110","author":"Eckelberg","year":"1970","journal-title":"Am. J. Roentgenol."},{"key":"2024092713410453700_bib19","doi-asserted-by":"crossref","first-page":"583","DOI":"10.2214\/ajr.129.4.583","article-title":"Acute cholecystitis: 137 patients studied by infusion tomography of the gallbladder","volume":"129","author":"Moncada","year":"1977","journal-title":"Am. J. Roentgenol."},{"key":"2024092713410453700_bib20","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2214\/ajr.127.1.69","article-title":"Computed tomography of the liver","volume":"127","author":"Alfidi","year":"1976","journal-title":"Am. J. Roentgenol."},{"key":"2024092713410453700_bib21","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1002\/bjs.1800631013","article-title":"Evaluation of biliary tract disease by ultrasonic B-mode scanning","volume":"63","author":"Addison","year":"1976","journal-title":"Br. J. Surg."},{"key":"2024092713410453700_bib22","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1056\/NEJM197703102961004","article-title":"Ultrasonic and radiographic cholecystography","volume":"296","author":"Bartrum","year":"1977","journal-title":"N. Engl. J. Med."},{"key":"2024092713410453700_bib23","first-page":"793","article-title":"Biliary scanning with Tc-99m pyridoxylideneglutamate\u2014the effect of food in normal subjects\u2014concise communication","volume":"18","author":"Baker","year":"1977","journal-title":"J. Nucl. Med."}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800680208","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/68\/2\/85\/59372064\/bjs1800680208.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/68\/2\/85\/59372064\/bjs1800680208.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T13:41:17Z","timestamp":1727444477000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/68\/2\/85\/6180657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,2,1]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1981,2,1]]},"published-print":{"date-parts":[[1981,2,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800680208","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"type":"print","value":"0007-1323"},{"type":"electronic","value":"1365-2168"}],"subject":[],"published-other":{"date-parts":[[1981,2]]},"published":{"date-parts":[[1981,2,1]]}}}