{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T04:21:48Z","timestamp":1727497308999},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1981,3,1]],"date-time":"1981-03-01T00:00:00Z","timestamp":352252800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The intraluminal gallbladder pressure has been measured in a conscious unsedated pig model by the use of a radiotelemetry pressure capsule. A loop fistula was incorporated to measure bile output simultaneously. Mean fasting intraluminal gallbladder pressure was found to be 15\u00b14 mmHg above atmospheric pressure, and mean fasting bile output 7\u00b75\u00b10\u00b78 ml\/10 min.<\/jats:p>\n               <jats:p>Following intravenous caerulein pressure peaked at 2 min with a mean rise of 17\u00b13 mmHg above basal (P&amp;lt;0\u00b7005). Bile output was increased for 30 min following caerulein with a total mean increase for this period of 13\u00b75\u00b12\u00b72 ml (P&amp;lt;0\u00b7005).<\/jats:p>\n               <jats:p>Gallbladder pressure rose significantly 5 min after commencing a meal by 6\u00b70\u00b11\u00b79 mmHg (P&amp;lt;0\u00b7025) reaching a peak pressure 65 min after the meal with a mean rise of 14\u00b78\u00b12\u00b73 mmHg (P&amp;lt;0\u00b7005). Bile output was significantly increased for 50 min following the ingestion of food. The total increments above basal values for bile output being 15\u00b79\u00b12\u00b77 ml (P&amp;lt;0\u00b7005) in the first 30 min post-randially and 11\u00b76\u00b12\u00b74 ml (P&amp;lt;0\u00b7005) in the 30\u201360 min period.<\/jats:p>\n               <jats:p>This model re-emphasizes the rapidity of the hormonal response and may be valuable for further studies on the physiology of post-randial gallbladder emptying.<\/jats:p>","DOI":"10.1002\/bjs.1800680305","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T20:30:28Z","timestamp":1172867428000},"page":"154-157","source":"Crossref","is-referenced-by-count":1,"title":["The effects of caerulein and a meal stimulus on gallbladder intraluminal pressure and bile flow in the pig"],"prefix":"10.1093","volume":"68","author":[{"given":"P","family":"Mitchenere","sequence":"first","affiliation":[{"name":"Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital , London. K. E. F. Hobbs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T E","family":"Adrian","sequence":"additional","affiliation":[{"name":"Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital , London. K. E. F. Hobbs"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K E F","family":"Hobbs","sequence":"additional","affiliation":[{"name":"Department of Surgery, Royal Free Hospital , London"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S R","family":"Bloom","sequence":"additional","affiliation":[{"name":"Department of Medicine, Royal Postgraduate Medical School, Hammersmith Hospital , London. K. E. F. 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