{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:17:57Z","timestamp":1761675477388},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[1981,12,1]],"date-time":"1981-12-01T00:00:00Z","timestamp":376012800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1981,12,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n               <jats:p>The perioperative course of 44 hyperthyroid patients prepared for surgery with propranolol alone, including 11 with severe thyrotoxicosis was compared to that of 20 euthyroid patients prepared for surgery with carbimazole. Conventional propranolol at a dosage of 160 mg\/day was frequently insufficient to produce a high degree of beta-adrenergic blockade, particularly in severely thyrotoxic patients. A greater than 25 per cent reduction in sitting pulse rate was associated with a high degree of beta-blockade. The clinical course of patients with mild or moderate thyrotoxicosis was similar to that of the patients prepared with carbimazole. In contrast, the course of severely thyrotoxic patients was complicated and, in addition to a higher preoperative propranolol dosage, these patients commonly required supplemental propranolol after operation. Although thyroid crisis did not occur in any patient, we cannot recommend the use of propranolol alone for the severely thyrotoxic patient.<\/jats:p>","DOI":"10.1002\/bjs.1800681211","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T20:13:37Z","timestamp":1172866417000},"page":"865-869","source":"Crossref","is-referenced-by-count":23,"title":["Propranolol in the surgical treatment of hyperthyroidism, including severely thyrotoxic patients"],"prefix":"10.1093","volume":"68","author":[{"given":"John","family":"Feely","sequence":"first","affiliation":[{"name":"Departments of Therapeutics, Anaesthetics and Surgery, Ninewells Hospital and Medical School Dundee ,","place":["Scotland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Crooks","sequence":"additional","affiliation":[{"name":"Departments of Therapeutics, Anaesthetics and Surgery, Ninewells Hospital and Medical School Dundee ,","place":["Scotland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A L","family":"Forrest","sequence":"additional","affiliation":[{"name":"Departments of Therapeutics, Anaesthetics and Surgery, Ninewells Hospital and Medical School Dundee ,","place":["Scotland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W F","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Departments of Therapeutics, Anaesthetics and Surgery, Ninewells Hospital and Medical School Dundee ,","place":["Scotland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrew","family":"Gunn","sequence":"additional","affiliation":[{"name":"Departments of Therapeutics, Anaesthetics and Surgery, Ninewells Hospital and Medical School Dundee ,","place":["Scotland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1981,12,1]]},"reference":[{"key":"2024092713481334700_bib1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1007\/BF01665097","article-title":"Propranolol in thyrotoxicosis-invited commentary","volume":"1","author":"Michie","year":"1977","journal-title":"World J. Surg."},{"key":"2024092713481334700_bib2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0039-6109(16)41731-7","article-title":"Reemergence of thyroidectomy as treatment for Graves' diseases","volume":"59","author":"Klementschitsch","year":"1979","journal-title":"Surg. Clin. North Am."},{"key":"2024092713481334700_bib3","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1097\/00000658-197306000-00025","article-title":"The use of propranolol in the surgical treatment of thyrotoxic patients","volume":"177","author":"Lee","year":"1973","journal-title":"Ann. Surg."},{"key":"2024092713481334700_bib4","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1016\/S0140-6736(74)90414-0","article-title":"Betablockade and partial thyroidectomy for thyrotoxicosis","volume":"1","author":"Michie","year":"1974","journal-title":"Lancet"},{"key":"2024092713481334700_bib5","first-page":"1352","article-title":"Beta-blocking drugs and thyroid function","volume":"2","author":"Feely","year":"1977","journal-title":"Br. Med. J."},{"key":"2024092713481334700_bib6","first-page":"908","article-title":"Propranolol for the pre-operative preparation of patients with thyrotoxicosis","volume":"146","author":"Caswell","year":"1978","journal-title":"Surg. Gynecol. Obstet."},{"key":"2024092713481334700_bib7","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1056\/NEJM197803232981202","article-title":"Thyroid function after surgical treatment to thyrotoxicosis: a report of 100 cases treated with propranolol before operation","volume":"298","author":"Toft","year":"1978","journal-title":"N. Engl. J. Med."},{"key":"2024092713481334700_bib8","first-page":"297","article-title":"Propranolol and thyroid resection for hyperthyroidism","volume":"145","author":"Anderberg","year":"1979","journal-title":"Acta Chir. Scand."},{"key":"2024092713481334700_bib9","first-page":"264","article-title":"Propranolol in thyrotoxicosis. II. Serum thyroid hormone concentrations during subtotal thyroidectomy","volume":"22","author":"Tevaarwerk","year":"1979","journal-title":"Can. J. Surg."},{"key":"2024092713481334700_bib10","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/0002-9343(79)91060-X","article-title":"Propranolol therapy in thyrotoxicosis. A review of 84 patients undergoing surgery","volume":"66","author":"Zonszein","year":"1979","journal-title":"Am. J. Med."},{"key":"2024092713481334700_bib11","first-page":"715","article-title":"Pre-operative treatment of thyrotoxicosis with a beta-blocking agent","volume":"141","author":"Ljunggren","year":"1975","journal-title":"Acta Chir. Scand."},{"key":"2024092713481334700_bib12","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1056\/NEJM197702032960509","article-title":"Propranolol does not prevent thyroid storm","volume":"296","author":"Erikkson","year":"1977","journal-title":"N. Engl. J. Med."},{"key":"2024092713481334700_bib13","first-page":"453","article-title":"Evaluation of propranolol in the pre-operative control of thyrotoxicosis","volume":"67","author":"Kapur","year":"1978","journal-title":"Ind. J. Med. Res."},{"key":"2024092713481334700_bib14","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1056\/NEJM197902153000707","article-title":"Variable propranolol levels in thyrotoxicosis","volume":"300","author":"Rubenfeld","year":"1979","journal-title":"N. Engl. J. Med."},{"key":"2024092713481334700_bib15","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1056\/NEJM197803232981210","article-title":"Treatment of Graves' disease","volume":"298","author":"Utiger","year":"1978","journal-title":"N. Engl. J. Med."},{"key":"2024092713481334700_bib16","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1097\/00000542-198006000-00003","article-title":"Halothaneinduced hepatic necrosis in triiodothyronine-pretreated rats","volume":"52","author":"Wood","year":"1980","journal-title":"Anesthesiology"},{"key":"2024092713481334700_bib17","first-page":"211","article-title":"Statistical methods applied to the clinical diagnosis of thyrotoxicosis","volume":"28","author":"Crooks","year":"1959","journal-title":"Q. J. Med."},{"key":"2024092713481334700_bib18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1111\/j.1365-2125.1974.tb00216.x","article-title":"The assessment of \u03b2-adrenoreceptor blocking drugs in hyperthyroidism","volume":"1","author":"Carruthers","year":"1974","journal-title":"Br. J. Clin. Pharmacol."},{"key":"2024092713481334700_bib19","doi-asserted-by":"crossref","first-page":"1885","DOI":"10.1002\/jps.2600631212","article-title":"GLC determination of propranolol, other \u03b2-blocking drugs and metabolites in biological fluids and tissues","volume":"63","author":"Walle","year":"1974","journal-title":"J. Pharm. Sci."},{"key":"2024092713481334700_bib20","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0009-8981(76)90394-6","article-title":"Simple solid-phase radioimmunoassay for total tri-iodothyronine and thyroxine in serum, and their clinical evaluation","volume":"68","author":"Seth","year":"1976","journal-title":"Clin. Chem. Acta"},{"key":"2024092713481334700_bib21","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1136\/bmj.1.5749.582","article-title":"Radioimmunoassay of human serum thyrotrophin","volume":"1","author":"Hall","year":"1971","journal-title":"Br. Med. J."},{"key":"2024092713481334700_bib22","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1111\/j.1365-2265.1981.tb02970.x","article-title":"Altered endocrine response to partial thyroidectomy in propranolol prepared hyperthyroid patients","volume":"14","author":"Feely","year":"1981","journal-title":"Clin. Endocrinol."},{"key":"2024092713481334700_bib23","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1210\/jcem-51-3-658","article-title":"Propranolol dosage in thyrotoxicosis","volume":"51","author":"Feely","year":"1980","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2024092713481334700_bib24","first-page":"100","volume-title":"Topics in Therapeutics","author":"McDevitt","year":"1977"},{"key":"2024092713481334700_bib25","doi-asserted-by":"crossref","first-page":"1312","DOI":"10.1210\/jcem-43-6-1312","article-title":"Propranolol in the treatment of thyrotoxicosis by subtotal thyroidectomy","volume":"43","author":"Toft","year":"1976","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2024092713481334700_bib26","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/0016-5085(78)90478-X","article-title":"Gut-thyroid interrelationships","volume":"75","author":"Miller","year":"1978","journal-title":"Gastroenterology"},{"key":"2024092713481334700_bib27","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S0025-7125(16)31978-2","article-title":"Post-operative jaundice","volume":"59","author":"Koff","year":"1975","journal-title":"Med. Clin. North Am."},{"key":"2024092713481334700_bib28","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0140-6736(79)90119-3","article-title":"Short term triiodothyronine in prevention of temporary hypothyroidism after subtotal thyroidectomy for Graves' disease","volume":"2","author":"Wilkin","year":"1979","journal-title":"Lancet"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800681211","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/68\/12\/865\/59372270\/bjs1800681211.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/68\/12\/865\/59372270\/bjs1800681211.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T13:48:24Z","timestamp":1727444904000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/68\/12\/865\/6185602"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,12,1]]},"references-count":28,"journal-issue":{"issue":"12","published-online":{"date-parts":[[1981,12,1]]},"published-print":{"date-parts":[[1981,12,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800681211","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"type":"print","value":"0007-1323"},{"type":"electronic","value":"1365-2168"}],"subject":[],"published-other":{"date-parts":[[1981,12]]},"published":{"date-parts":[[1981,12,1]]}}}