{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T04:23:17Z","timestamp":1727497397877},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1982,2,1]],"date-time":"1982-02-01T00:00:00Z","timestamp":381369600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1982,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The renal handling of calcium and phosphate, which normally reflects parathyroid hormone (PTH) activity, was studied during the first 5 days after admission to hospital in 18 patients with acute pancreatitis. The ionized calcium level in plasma was calculated from the total calcium, albumin, total protein and pH. Hypocalcaemia (Ca &amp;lt; 1\u00b708) was found in 6 patients and was associated with low urine calcium concentrations, hypophosphataemia and lower renal tubular reabsorptions of phosphate. Although these changes were all consistent with an appropriate renal response to increased PTH production in the hypocalcaemic patients, measured levels of PTH were very variable. In one patient who developed tetany, calcium infusion resulted in a rise in plasma calcium and a reversal of renal changes, but had little influence upon PTH levels. We found no evidence that hypomagnesaemia or proteolytic degradation of PTH were factors in the aetiology of hypocalcaemia.<\/jats:p>\n               <jats:p>The discrepancy between evidence of PTH activity from renal function and immunoassayable levels of PTH in plasma might indicate that the parathyroid response, although present, was inadequate to mobilize enough skeletal calcium to prevent hypocalcaemia; it underlines the need for caution in the interpretation of data from radioimmunoassay techniques when taken in isolation in situations where they have not been fully evaluated.<\/jats:p>","DOI":"10.1002\/bjs.1800690213","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T21:45:12Z","timestamp":1172871912000},"page":"95-98","source":"Crossref","is-referenced-by-count":3,"title":["Parathyroid function during acute pancreatitis"],"prefix":"10.1093","volume":"69","author":[{"given":"M J","family":"McMahon","sequence":"first","affiliation":[{"name":"University Department of Surgery, and MRC Mineral Metabolism Unit, The General Infirmary , Leeds"},{"name":"Department of Medical Biochemistry, University Hospital of Wales , Cardiff"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Heyburn","sequence":"additional","affiliation":[{"name":"University Department of Surgery, and MRC Mineral Metabolism Unit, The General Infirmary , Leeds"},{"name":"Department of Medical Biochemistry, University Hospital of Wales , Cardiff"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M J","family":"Playforth","sequence":"additional","affiliation":[{"name":"University Department of Surgery, and MRC Mineral Metabolism Unit, The General Infirmary , Leeds"},{"name":"Department of Medical Biochemistry, University Hospital of Wales , Cardiff"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J S","family":"Woodhead","sequence":"additional","affiliation":[{"name":"University Department of Surgery, and MRC Mineral Metabolism Unit, The General Infirmary , Leeds"},{"name":"Department of Medical Biochemistry, University Hospital of Wales , Cardiff"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1982,2,1]]},"reference":[{"key":"2024092713082963100_bib1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/0002-9343(71)90119-7","article-title":"Parathyroid hormone: sequence, synthesis and immunoassay studies","volume":"50","author":"Potts","year":"1971","journal-title":"Am. J. Med."},{"key":"2024092713082963100_bib2","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1172\/JCI104081","article-title":"Calcium and phosphorous homeostasis in the parathyroidectomised dog: evaluation by means of ethylenediamine tetracetate and calcium tolerance tests","volume":"39","author":"Sanderson","year":"1960","journal-title":"J. Clin. Invest."},{"key":"2024092713082963100_bib3","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1002\/bjs.1800650323","article-title":"The nature of hypocalcaemia in acute pancreatitis","volume":"65","author":"McMahon","year":"1978","journal-title":"Br. J. Surg."},{"key":"2024092713082963100_bib4","first-page":"388","volume-title":"The Parathyroids","author":"Bartter","year":"1961"},{"key":"2024092713082963100_bib5","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1016\/S0140-6736(69)91353-1","article-title":"Relation between serum and urinary calcium with particular reference to parathyroid hormone","volume":"1","author":"Peacock","year":"1969","journal-title":"Lancet"},{"key":"2024092713082963100_bib6","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1126\/science.177.4049.606","article-title":"Evidence for parathyroid failure in magnesium deficiency","volume":"177","author":"Quast","year":"1972","journal-title":"Science"},{"key":"2024092713082963100_bib7","first-page":"209","article-title":"Prognostic signs and non-operative peritoneal lavage in acute pancreatitis","volume":"143","author":"Ranson","year":"1976","journal-title":"Surg. Gynecol. Obstet."},{"key":"2024092713082963100_bib8","first-page":"469","volume-title":"Calcium, Phosphate and Magnesium Metabolism","author":"Nordin","year":"1976"},{"key":"2024092713082963100_bib9","first-page":"162","volume-title":"Calcium, Phosphate and Magnesium Metabolism","author":"Marshall","year":"1976"},{"key":"2024092713082963100_bib10","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3109\/10408367909105859","article-title":"Calcium measurements in serum and plasma\u2014total and ionised","volume":"9","author":"Robertson","year":"1979","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"2024092713082963100_bib11","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/S0140-6736(75)92736-1","article-title":"Nomogram for derivation of renal threshold phosphate concentration","volume":"2","author":"Walton","year":"1975","journal-title":"Lancet"},{"key":"2024092713082963100_bib12","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1677\/joe.0.0490521","article-title":"Immuno-radiometric assay of parathyroid hormone","volume":"42","author":"Addison","year":"1971","journal-title":"J. Endocrinol."},{"key":"2024092713082963100_bib13","first-page":"240","article-title":"Calcium changes in acute pancreatic necrosis","volume":"79","author":"Edmondson","year":"1944","journal-title":"Surg. Gynecol. Obslet."},{"key":"2024092713082963100_bib14","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1002\/bjs.1800640917","article-title":"Serum ionized calcium in acute pancreatitis","volume":"64","author":"Allam","year":"1977","journal-title":"Br. J. Surg."},{"key":"2024092713082963100_bib15","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1056\/NEJM197603042941002","article-title":"Inadequate parathyroid response in acute pancreatitis","volume":"294","author":"Robertson","year":"1976","journal-title":"N. Engl. J. Med."},{"key":"2024092713082963100_bib16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.7326\/0003-4819-83-2-185","article-title":"The hypocalcaemia of acute pancreatitis","volume":"83","author":"Weir","year":"1975","journal-title":"Ann. Intern. Med."},{"key":"2024092713082963100_bib17","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1185\/03007997609109289","article-title":"Hypocalcaemia of acute pancreatitis: the effect of hypoalbuminaemia","volume":"4","author":"Imrie","year":"1976","journal-title":"Curr. Med. Res. Opin."},{"key":"2024092713082963100_bib18","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1002\/bjs.1800620209","article-title":"The aetiology of hypocalcaemia in acute pancreatitis","volume":"62","author":"Condon","year":"1975","journal-title":"Br. J. Surg."},{"key":"2024092713082963100_bib19","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/bjs.1800651013","article-title":"Parathyroid hormone and calcium homeostasis in acute pancreatitis","volume":"65","author":"Imrie","year":"1978","journal-title":"Br. J. Surg."},{"key":"2024092713082963100_bib20","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/0002-9343(78)90519-3","article-title":"The first 24 hours of acute pancreatitis","volume":"64","author":"Drew","year":"1978","journal-title":"Am. J. Med."},{"key":"2024092713082963100_bib21","first-page":"190","article-title":"Renal function and blood levels of divalent ions in acute pancreatitis","volume":"3","author":"Haldimann","year":"1980","journal-title":"Min. Elect. Metab."},{"key":"2024092713082963100_bib22","doi-asserted-by":"crossref","first-page":"357","DOI":"10.7326\/0003-4819-78-3-357","article-title":"Skeletal resistance to parathyroid hormone in renal failure: study in 105 human subjects","volume":"78","author":"Massey","year":"1973","journal-title":"Ann. Intern. Med."}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800690213","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/69\/2\/95\/59371661\/bjs1800690213.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/69\/2\/95\/59371661\/bjs1800690213.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T13:08:39Z","timestamp":1727442519000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/69\/2\/95\/6188758"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,2,1]]},"references-count":22,"journal-issue":{"issue":"2","published-online":{"date-parts":[[1982,2,1]]},"published-print":{"date-parts":[[1982,2,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800690213","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"type":"print","value":"0007-1323"},{"type":"electronic","value":"1365-2168"}],"subject":[],"published-other":{"date-parts":[[1982,2]]},"published":{"date-parts":[[1982,2,1]]}}}