{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,25]],"date-time":"2026-03-25T03:25:54Z","timestamp":1774409154302,"version":"3.50.1"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1982,5,1]],"date-time":"1982-05-01T00:00:00Z","timestamp":389059200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1982,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>A group of 500 patients with a presumptive diagnosis of primary hyperparathyroidism (HPT) was operated upon at the Mayo Clinic between September 1974 and May 1980 using a standardized operative strategy. Clinical profiles, biochemical data, operative findings and pathological changes are reviewed. Of the 500 patients, 461 (92\u00b72 per cent) were cured after primary cervical exploration. One patient died during the postoperative period, 1 had a permanent unilateral vocal cord paralysis and 10 (2 per cent) had protracted hypoparathyroidism. Owing to the continuing controversy regarding the appropriate therapeutic management of asymptomatic, uncomplicated and mild (\u2018biochemical\u2019) primary HPT, we further evaluated this surgical experience by comparing the results of operation in two groups of patients: those with (\u2018biochemical\u2019) HPT (serum calcium &amp;lt; 11 mg\/dl) and those with \u2018non-biochemical\u2019 HPT (symptomatic or complicated disease or serum calcium &amp;gt; 11 mg\/dl). The cure rate in each patient group was greater than 90 per cent. A statistically significant increase in the incidence of negative cervical exploration (4 normal parathyroid glands identified and biopsied) was noted in the \u2018biochemical\u2019 group. However, parathyroid disease was found at operation in 92 per cent of these patients. We conclude that cervical exploration in all patients with primary HPT, including those with \u2018biochemical\u2019 disease only, is safe and that such an aggressive management policy is justified.<\/jats:p>","DOI":"10.1002\/bjs.1800690503","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T21:54:10Z","timestamp":1172872450000},"page":"244-247","source":"Crossref","is-referenced-by-count":137,"title":["Surgery for primary hyperparathyroidism: Experience with 500 consecutive cases and evaluation of the role of surgery in the asymptomatic patient"],"prefix":"10.1093","volume":"69","author":[{"given":"Colin F","family":"Russell","sequence":"first","affiliation":[{"name":"Department of Surgery, Mayo Clinic and Mayo Foundation , Rochester, Minnesota,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony J","family":"Edis","sequence":"additional","affiliation":[{"name":"Department of Surgery, Mayo Clinic and Mayo Foundation , Rochester, Minnesota,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1982,5,1]]},"reference":[{"key":"2024092714262616200_bib1","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/0002-9343(71)90122-7","article-title":"Primary hyperparathyroidism: a prospective clinical study","volume":"50","author":"Purnell","year":"1971","journal-title":"Am. J. Med."},{"key":"2024092714262616200_bib2","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/0002-9343(74)90808-0","article-title":"Treatment of primary hyperparathyroidism","volume":"56","author":"Purnell","year":"1974","journal-title":"Am. J. Med."},{"key":"2024092714262616200_bib3","doi-asserted-by":"crossref","first-page":"468","DOI":"10.7326\/0003-4819-63-3-468","article-title":"Hyperparathyroidism detected by routine serum calcium analysis: prevalence in a clinic population","volume":"63","author":"Boonstra","year":"1965","journal-title":"Ann. Intern. Med."},{"key":"2024092714262616200_bib4","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1445-5994.1975.tb04572.x","article-title":"The effect of multiphasic biochemical screening on the diagnosis of primary hyperparathyroidism","volume":"5","author":"Aitken","year":"1975","journal-title":"Aust. NZ J. 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Surg."},{"key":"2024092714262616200_bib8","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1002\/bjs.1800671014","article-title":"Surgery of hyperparathyroid disease","volume":"67","author":"Taylor","year":"1980","journal-title":"Br. J. Surg."}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800690503","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/69\/5\/244\/59372972\/bjs1800690503.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/69\/5\/244\/59372972\/bjs1800690503.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T14:26:34Z","timestamp":1727447194000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/69\/5\/244\/6185769"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,5,1]]},"references-count":8,"journal-issue":{"issue":"5","published-online":{"date-parts":[[1982,5,1]]},"published-print":{"date-parts":[[1982,5,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800690503","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1982,5]]},"published":{"date-parts":[[1982,5,1]]}}}