{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:39:11Z","timestamp":1789472351643,"version":"build-2803163510"},"reference-count":10,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[1982,10,1]],"date-time":"1982-10-01T00:00:00Z","timestamp":402278400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1982,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The clinical features and management of 90 thyrotoxic and 11 euthyroid patients with a single autonomous hot nodule in the thyroid have been reviewed to assess the results of surgery and radio-iodine therapy. Symptoms and signs of thyrotoxicosis were often minimal but histories were frequently long with cardiac complications predominating. Thyrotoxicosis was permanently eradicated in the 60 patients treated surgically, although hypothyroidism occurred in 6\u00b76 per cent. Twelve of the 37 (32 per cent) thyrotoxic patients receiving radio-iodine needed further definitive treatment for persistent or recurrent thyrotoxicosis, but only 2 patients (5 per cent) became hypothyroid. Early surgery for the autonomous toxic thyroid nodule ensures control of the thyroid overactivity and minimizes the risk of permanent cardiac damage. The absence of morbidity justifies surgical excision of autonomous hot nodules in patients who are euthyroid to eliminate the risk of thyrotoxicosis supervening.<\/jats:p>","DOI":"10.1002\/bjs.1800691006","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T21:32:15Z","timestamp":1172871135000},"page":"577-579","source":"Crossref","is-referenced-by-count":37,"title":["The treatment of autonomous functioning thyroid nodules"],"prefix":"10.1093","volume":"69","author":[{"given":"I A","family":"Eyre-Brook","sequence":"first","affiliation":[{"name":"Department of Surgery, Royal Hallamshire Hospital , Sheffield S10 2JF"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C H","family":"Talbot","sequence":"additional","affiliation":[{"name":"Department of Surgery, Royal Hallamshire Hospital , Sheffield S10 2JF"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1982,10,1]]},"reference":[{"key":"2024092713052620400_bib1","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1016\/S0001-2998(71)81035-8","article-title":"Treatment of diffuse toxic goitre with 131I","volume":"1","author":"Dworkin","year":"1971","journal-title":"Semin. Nucl. Med."},{"key":"2024092713052620400_bib2","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1001\/archinte.1962.03620240070011","article-title":"Radioiodine in diagnosis and therapy of hyperthyroidism","volume":"110","author":"Skillern","year":"1962","journal-title":"Arch. Intern. Med."},{"key":"2024092713052620400_bib3","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1001\/archsurg.1968.01330210064011","article-title":"The autonomous functioning thyroid nodules","volume":"96","author":"Miller","year":"1968","journal-title":"Arch. Surg."},{"key":"2024092713052620400_bib4","first-page":"515","article-title":"306 cases of toxic adenoma: clinical aspects, findings on radioiodine diagnostics, radiochromatography and histology: results of 131I and surgical treatment","volume":"8","author":"Horst","year":"1967","journal-title":"J. Nucl. Med."},{"key":"2024092713052620400_bib5","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1016\/0002-9343(75)90630-0","article-title":"Solitary autonomously functioning thyroid lesions","volume":"58","author":"Hamburger","year":"1975","journal-title":"Am. J. Med."},{"key":"2024092713052620400_bib6","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1111\/j.1365-2265.1979.tb03035.x","article-title":"Standard dose 131I therapy for hyperthyroidism caused by autonomously functioning thyroid nodules","volume":"10","author":"Ng Tang Fui","year":"1979","journal-title":"Clin. Endocrinol."},{"key":"2024092713052620400_bib7","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1002\/bjs.1800671013","article-title":"The treatment and preoperative diagnosis of differentiated thyroid carcinoma presenting as a clinically solitary nodule","volume":"67","author":"Wade","year":"1980","journal-title":"Br. J. Surg."},{"key":"2024092713052620400_bib8","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1001\/archsurg.1971.01350120123024","article-title":"An autonomously functioning thyroid nodule, cancer and prior irradiation","volume":"103","author":"Meier","year":"1971","journal-title":"Arch. Surg."},{"key":"2024092713052620400_bib9","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1001\/archsurg.1971.01350120126025","article-title":"Cancer following treatment of an autonomously functioning thyroid nodule with sodium iodine 131I","volume":"103","author":"Hamburger","year":"1971","journal-title":"Arch. Surg."},{"key":"2024092713052620400_bib10","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1210\/jcem-50-6-1089","article-title":"Evolution of toxicity in solitary non-toxic autonomously functioning thyroid nodules","volume":"50","author":"Hamburger","year":"1980","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800691006","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/69\/10\/577\/59371506\/bjs1800691006.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/69\/10\/577\/59371506\/bjs1800691006.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T13:05:37Z","timestamp":1727442337000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/69\/10\/577\/6185981"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1982,10,1]]},"references-count":10,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1982,10,1]]},"published-print":{"date-parts":[[1982,10,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800691006","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1982,10]]},"published":{"date-parts":[[1982,10,1]]}}}