{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:25Z","timestamp":1761058645701},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[1983,10,1]],"date-time":"1983-10-01T00:00:00Z","timestamp":433814400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1983,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The relationship between the rate of 111In-platelet deposition on vascular grafts and subsequent thrombosis has been examined in patients undergoing femoropopliteal by-pass. Sixty-seven patients undergoing femoropopliteal by-pass using vein, Dacron or PTFE were randomized to aspirin plus dipyridamole (ASA\/DPM) or placebo. Autologous 111In-platelets were injected in the second postoperative week and Thrombogenicity Index (TI) calculated as the mean daily rise in the ratio of radioactivity graft\/contralateral thigh. Graft patency was assessed to 1 year. Mean (+ s.e.m.) TI at 1 week in 21 grafts that occluded within 12 months was 0\u00b719 \u00b1 0\u00b7018 compared with 0\u00b707 \u00b1 0\u00b7009 in the 38 that remained patient (P &amp;lt; 0\u00b7001). Grafts with a TI less or greater than the median had a 90 per cent or 39 per cent cumulative 1-year patency, respectively (P &amp;lt; 0\u00b7001). In the prosthetic grafts ASA\/DPM reduced mean TI from 0\u00b717 \u00b1 0\u00b702 to 0\u00b711 \u00b1 0\u00b701 (P &amp;lt; 0\u00b702) and enhanced 1-year patency from 36 to 67 per cent (P &amp;lt; 0\u00b705). Following femoropopliteal by-pass TI related to subsequent graft patency. Radiolabelled platelet deposition therefore provides a guide as to how new materials or antithrombotic drugs may influence clinical graft thrombosis. Platelet inhibition reduced both graft thrombogenicity and subsequent occlusion.<\/jats:p>","DOI":"10.1002\/bjs.1800701019","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T22:51:10Z","timestamp":1172875870000},"page":"635-638","source":"Crossref","is-referenced-by-count":73,"title":["Does 111indium-platelet deposition predict patency in prosthetic arterial grafts?"],"prefix":"10.1093","volume":"70","author":[{"given":"M","family":"Goldman","sequence":"first","affiliation":[{"name":"Department of Surgery, Queen Elizabeth Medical Centre , Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C","family":"Hall","sequence":"additional","affiliation":[{"name":"Department of Surgery, Queen Elizabeth Medical Centre , Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Dykes","sequence":"additional","affiliation":[{"name":"Department of Surgery, Queen Elizabeth Medical Centre , Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R J","family":"Hawker","sequence":"additional","affiliation":[{"name":"Department of Surgery, Queen Elizabeth Medical Centre , Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C N","family":"McCollum","sequence":"additional","affiliation":[{"name":"Department of Surgery, Queen Elizabeth Medical Centre , Birmingham"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1983,10,1]]},"reference":[{"key":"2024092715094715300_bib1","first-page":"131","volume-title":"Biologic and Synthetic Vascular Prostheses","author":"Clagett","year":"1982"},{"key":"2024092715094715300_bib2","doi-asserted-by":"crossref","first-page":"882","DOI":"10.1016\/0002-9149(81)90189-2","article-title":"Indium-111 platelet imaging for detection of platelet deposition in abdominal aneurysms and prosthetic arterial grafts","volume":"47","author":"Ritchie","year":"1981","journal-title":"Am. 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