{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T09:11:56Z","timestamp":1790413916827,"version":"4.1.0"},"reference-count":19,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1984,3,1]],"date-time":"1984-03-01T00:00:00Z","timestamp":446947200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>With the recent trend towards more distal lower limb and below-knee amputation for peripheral vascular disease, failure of amputation healing remains a common clinical problem. There is an urgent need for more objective measures of selecting the most appropriate distal amputation level compatible with healing. Oxygen availability is the final arbiter of tissue viability and healing potential, and we have shown that the measurement of transcutaneous pO2 (TcpO2) accurately reflects the degree of ischaemia in the lower limb. In 59 patients having 62 amputations for peripheral vascular disease significantly lower TcpO2 levels were related to amputation failure. Below-knee amputations with a pre-operative below-knee TcpO2 of above 35 mmHg always healed, and failures had levels of 35 mmHg or less. Nine out of sixteen patients having above-knee amputations had pre-operative below-knee TcpO2 values well above 35 mmHg, suggesting that they may possibly have undergone successful below-knee amputation. No correlation between ankle systolic pressure and amputation healing was found. TcpO2 measurement is simple, non-invasive and reliable and offers an exciting research advance in the assessment of effective tissue perfusion.<\/jats:p>","DOI":"10.1002\/bjs.1800710320","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T00:39:18Z","timestamp":1172882358000},"page":"219-222","source":"Crossref","is-referenced-by-count":76,"title":["Prediction of amputation wound healing: The role of transcutaneous pO2 assessment"],"prefix":"10.1093","volume":"71","author":[{"given":"D A","family":"Ratliff","sequence":"first","affiliation":[{"name":"Vascular Surgical Unit, Royal South Hants Hospital , Graham Road, Southampton,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C A C","family":"Clyne","sequence":"additional","affiliation":[{"name":"Vascular Surgical Unit, Royal South Hants Hospital , Graham Road, Southampton,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A D B","family":"Chant","sequence":"additional","affiliation":[{"name":"Vascular Surgical Unit, Royal South Hants Hospital , Graham Road, Southampton,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H H","family":"Webster","sequence":"additional","affiliation":[{"name":"Vascular Surgical Unit, Royal South Hants Hospital , Graham Road, Southampton,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1984,3,1]]},"reference":[{"key":"2024092716194312400_bib1","volume-title":"The Annual Report of the Chief Medical Officer of the Department of Health and Social Security","year":"1981"},{"key":"2024092716194312400_bib2","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1002\/bjs.1800670403","article-title":"Amputation for vascular disease: the experience of a peripheral vascular unit","volume":"67","author":"Finch","year":"1980","journal-title":"Br J Surg"},{"key":"2024092716194312400_bib3","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1001\/archsurg.1980.01380100032007","article-title":"Below-knee amputation: is the effort to preserve the knee-joint justifiedarticle-title","volume":"115","author":"Castronuovo","year":"1980","journal-title":"Arch Surg"},{"key":"2024092716194312400_bib4","first-page":"50","article-title":"Major lower limb amputation reassessed","volume":"26","author":"Moffat","year":"1980","journal-title":"J R Coll Surg Edinb."},{"key":"2024092716194312400_bib5","first-page":"493","article-title":"Below-knee amputation for ischaemic gangrene","volume":"125","author":"Lim","year":"1967","journal-title":"Surg Gynecol Obstet"},{"key":"2024092716194312400_bib6","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1001\/archsurg.1981.01380130056013","article-title":"Prediction of amputation wound healing. Roles of Doppler ultrasound and digit photoplethysmography","volume":"116","author":"Barnes","year":"1981","journal-title":"Arch Surg"},{"key":"2024092716194312400_bib7","first-page":"278","article-title":"Doppler ultrasound in the assessment of amputation level","volume":"26","author":"Creaney","year":"1981","journal-title":"J R Coll Surg Edinb."},{"key":"2024092716194312400_bib8","doi-asserted-by":"crossref","first-page":"363","DOI":"10.2106\/00004623-198365030-00011","article-title":"Doppler-determined segmental pressures and wound-healing in amputations for vascular disease","volume":"65A","author":"Cederberg","year":"1983","journal-title":"J Bone Joint Surg"},{"key":"2024092716194312400_bib9","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1001\/archsurg.1981.01380130062014","article-title":"Prospective use of Xenon Xe133 clearance for amputation level selection","volume":"116","author":"Moore","year":"1981","journal-title":"Arch Surg"},{"key":"2024092716194312400_bib10","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1001\/archsurg.1973.01350230150027","article-title":"Determination of amputation level: measurement of skin blood flow with Xenon Xe133","volume":"107","author":"Moore","year":"1973","journal-title":"Arch Surg"},{"key":"2024092716194312400_bib11","doi-asserted-by":"crossref","first-page":"833","DOI":"10.2106\/00004623-197658060-00014","article-title":"The measurement of skin blood flow in peripheral vascular disease by epicutaneous application of Xenon133","volume":"58A","author":"Kostnik","year":"1976","journal-title":"J Bone Joint Surg"},{"key":"2024092716194312400_bib12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3109\/17453677909024089","article-title":"Wound healing in below-knee amputations in relation to skin perfusion pressure","volume":"50","author":"Holstein","year":"1979","journal-title":"Acta Orthop Scand"},{"key":"2024092716194312400_bib13","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1177\/000331978103200302","article-title":"Amputation of the ischaemic limb: selection of the optimum site by thermography","volume":"32","author":"Spence","year":"1981","journal-title":"Angiology"},{"key":"2024092716194312400_bib14","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1001\/archsurg.1981.01380130065015","article-title":"Lower-extremity amputations forischaemia","volume":"116","author":"Porter","year":"1981","journal-title":"Arch Surg"},{"key":"2024092716194312400_bib15","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1002\/bjs.1800630904","article-title":"Amputation for vascular disease","volume":"63","author":"Jamieson","year":"1976","journal-title":"Br J Surg"},{"key":"2024092716194312400_bib16","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0002-9610(82)90099-X","article-title":"Oxygen tension on the skin of ischaemic legs","volume":"143","author":"Clyne","year":"1982","journal-title":"Am J Surg"},{"key":"2024092716194312400_bib17","first-page":"249","article-title":"Choice of level of amputation in ischaemic arterial disease","volume":"31","author":"Browse","year":"1973","journal-title":"Scand J Clin Lab Invest"},{"key":"2024092716194312400_bib18","first-page":"124","volume-title":"Amputations and Prostheses","author":"Vitali","year":"1978"},{"key":"2024092716194312400_bib19","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/BF00667211","article-title":"Quantitative polarographische sauerstoffdruckmessung auf der kopfhaut des neugeborenen","volume":"207","author":"Huch","year":"1969","journal-title":"Arch Gynaekol"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800710320","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/71\/3\/219\/59377460\/bjs1800710320.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/71\/3\/219\/59377460\/bjs1800710320.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T16:20:16Z","timestamp":1727454016000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/71\/3\/219\/6186123"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,3,1]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[1984,3,1]]},"published-print":{"date-parts":[[1984,3,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800710320","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1984,3]]},"published":{"date-parts":[[1984,3,1]]}}}