{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:30:12Z","timestamp":1761597012286},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1984,6,1]],"date-time":"1984-06-01T00:00:00Z","timestamp":454896000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The macrophage contents of 40 human primary breast cancers were ascertained using three separate macrophage membrane markers. Four prognostic factors (lymph node status, tumour size, histological grade and oestrogen receptor status) were determined concurrently in these mammary carcinomas. No significant relationship was found between the macrophage content of the mammary carcinomas and any individual prognostic factor. When the patients were grouped according to whether they had 0\u20132 or 3\u20134 high risk factors, however, the macrophage content was significantly greater in those tumours with the poorer prognosis, regardless of the marker used to enumerate the cells. A high macrophage content, therefore, is not associated with favourable prognostic factors in breast cancer. Indeed, the present study has revealed the reverse to be the case.<\/jats:p>","DOI":"10.1002\/bjs.1800710618","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T00:32:34Z","timestamp":1172881954000},"page":"456-458","source":"Crossref","is-referenced-by-count":22,"title":["A high macrophage content in human breast cancer is not associated with favourable prognostic factors"],"prefix":"10.1093","volume":"71","author":[{"given":"R J C","family":"Steele","sequence":"first","affiliation":[{"name":"University Department of Clinical Surgery, Royal Infirmary , Edinburgh EH3 9YW,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Eremin","sequence":"additional","affiliation":[{"name":"University Department of Clinical Surgery, Royal Infirmary , Edinburgh EH3 9YW,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Brown","sequence":"additional","affiliation":[{"name":"University Department of Clinical Surgery, Royal Infirmary , Edinburgh EH3 9YW,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R A","family":"Hawkins","sequence":"additional","affiliation":[{"name":"University Department of Clinical Surgery, Royal Infirmary , Edinburgh EH3 9YW,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1984,6,1]]},"reference":[{"key":"2024092716230778000_bib1","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/250667a0","article-title":"Macrophage content of tumours in relation to metastatic spread and host immune reaction","volume":"250","author":"Eccles","year":"1974","journal-title":"Nature"},{"key":"2024092716230778000_bib2","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/ijc.2910260618","article-title":"Macrophage content and immunogenicity of C57BL\/6J and BALB cByJ methylcholanthrene-induced sarcomas","volume":"26","author":"Evans","year":"1980","journal-title":"Int J Cancer"},{"key":"2024092716230778000_bib3","doi-asserted-by":"crossref","first-page":"2245","DOI":"10.4049\/jimmunol.126.6.2245","article-title":"Macrophage content of metastatic and non-metastatic rodent neoplasms","volume":"126","author":"Talmadge","year":"1981","journal-title":"J Immunol"},{"key":"2024092716230778000_bib4","doi-asserted-by":"crossref","first-page":"2917","DOI":"10.1002\/1097-0142(19800615)45:12<2917::AID-CNCR2820451203>3.0.CO;2-M","article-title":"Management and survival of female breast cancer","volume":"45","author":"Nemoto","year":"1980","journal-title":"Cancer"},{"key":"2024092716230778000_bib5","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1002\/1097-0142(196911)24:5<1071::AID-CNCR2820240533>3.0.CO;2-H","article-title":"Cancer of the breast: size of neoplasm and prognosis","volume":"24","author":"Fisher","year":"1969","journal-title":"Cancer"},{"key":"2024092716230778000_bib6","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/bjc.1957.43","article-title":"Histological grading and prognosis in breast cancer","volume":"11","author":"Bloom","year":"1957","journal-title":"Br J Cancer"},{"key":"2024092716230778000_bib7","first-page":"4669","article-title":"Estrogen receptor as an independent prognostic factor for early recurrence in breast cancer","volume":"37","author":"Knight","year":"1977","journal-title":"Cancer Res"},{"key":"2024092716230778000_bib8","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/BF01806264","article-title":"Oestrogen receptor concentration in primary breast cancer and axillary node metastases","volume":"1","author":"Hawkins","year":"1981","journal-title":"Breast Cancer Research and Treatment"},{"key":"2024092716230778000_bib9","first-page":"279","volume-title":"Mechanisms of Lymphocyte Activation","author":"Kraft","year":"1979"},{"key":"2024092716230778000_bib10","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1159\/000231693","article-title":"T and B lymphocyte populations in human normal lymph node, regional tumour lymph node and inflammatory lymph node","volume":"52","author":"Eremin","year":"1976","journal-title":"Int Arch Allergy Appl Immunol"},{"key":"2024092716230778000_bib11","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0022-1759(77)90157-0","article-title":"Comparison of the direct antiglobulin resetting reaction with the mixed anti-globulin rosetting reaction for the detection of immunoglobulin on lymphocytes","volume":"18","author":"Coombs","year":"1977","journal-title":"J Immunol Methods"},{"key":"2024092716230778000_bib12","first-page":"143","article-title":"Evidence for mononuclear phagocytes in solid neoplasms and appraisal of their nonspecific cytotoxic capabilities","volume":"10","author":"Russell","year":"1981","journal-title":"Contemp Topics in Immunobiol"},{"key":"2024092716230778000_bib13","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1038\/263063a0","article-title":"Presence of HLA-D determinants on human macrophages","volume":"263","author":"Hirchberg","year":"1976","journal-title":"Nature"},{"key":"2024092716230778000_bib14","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1002\/1097-0142(19810401)47:7<1786::AID-CNCR2820470711>3.0.CO;2-8","article-title":"Distribution of epithelial membrane antigen in normal and neoplastic tissues and its value in diagnostic tumour pathology","volume":"47","author":"Sloane","year":"1981","journal-title":"Cancer"},{"key":"2024092716230778000_bib15","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1093\/jnci\/59.4.1081","article-title":"Detection and quantitation of macrophage infiltration into primary human tumours with the use of cell-surface markers","volume":"59","author":"Wood","year":"1977","journal-title":"J Natl Cancer Inst"},{"key":"2024092716230778000_bib16","first-page":"411","volume-title":"The Macrophage and Cancer","author":"Lauder","year":"1977"},{"key":"2024092716230778000_bib17","first-page":"941","article-title":"Blood monocytes and tumour-infiltrating macrophages in human breast cancer: differences in activation level as assessed by lysozyme content","volume":"71","author":"Steele","year":"1983","journal-title":"J Natl Cancer Inst"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800710618","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/71\/6\/456\/59378118\/bjs1800710618.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/71\/6\/456\/59378118\/bjs1800710618.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T16:23:20Z","timestamp":1727454200000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/71\/6\/456\/6181403"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,6,1]]},"references-count":17,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1984,6,1]]},"published-print":{"date-parts":[[1984,6,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800710618","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"type":"print","value":"0007-1323"},{"type":"electronic","value":"1365-2168"}],"subject":[],"published-other":{"date-parts":[[1984,6]]},"published":{"date-parts":[[1984,6,1]]}}}