{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T14:01:35Z","timestamp":1791295295862,"version":"4.1.0"},"reference-count":8,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[1984,8,1]],"date-time":"1984-08-01T00:00:00Z","timestamp":460166400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Samples of ileal serosa and mesenteric lymph nodes have been harvested before antibiotic administration during 46 non-contaminated operations for Crohn's disease and compared with 43 operations for conditions other than Crohn's. Potentially pathogenic bacteria were isolated from the serosa in 12 (27 per cent) Crohn's patients, compared with 6 (15 per cent) controls (P = 0.04). Intestinal bacteria were recovered from mesenteric nodes in 15 (33 per cent) Crohn's patients compared with 2 (5 per cent) controls (P = 0.006). These findings suggest that bacteria leak from the small bowel lumen in a high proportion of Crohn's disease patients. This may explain the pathogenesis of abscess and fistula in this disorder as well as the high rate of sepsis following elective surgery even in the absence of macroscopic contamination.<\/jats:p>","DOI":"10.1002\/bjs.1800710821","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T00:49:00Z","timestamp":1172882940000},"page":"623-625","source":"Crossref","is-referenced-by-count":170,"title":["Incidence of pathogenic bacteria from mesenteric lymph nodes and ileal serosa during Crohn's disease surgery"],"prefix":"10.1093","volume":"71","author":[{"given":"N S","family":"Ambrose","sequence":"first","affiliation":[{"name":"Departments of Surgery and Microbiology, The General Hospital , Birmingham B4 6NH,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Johnson","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Microbiology, The General Hospital , Birmingham B4 6NH,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D W","family":"Burdon","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Microbiology, The General Hospital , Birmingham B4 6NH,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M R B","family":"Keighley","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Microbiology, The General Hospital , Birmingham B4 6NH,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1984,8,1]]},"reference":[{"key":"2024092716392967600_bib1","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1007\/BF02587605","article-title":"Sepsis following surgery for inflammatory bowel disease","volume":"23","author":"Higgens","year":"1981","journal-title":"Dis Colon Rectum"},{"key":"2024092716392967600_bib2","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1002\/bjs.1800690416","article-title":"Clinical trials of the efficacy and duration of antibacterial cover for elective resection in inflammatory bowel disease","volume":"69","author":"Hares","year":"1982","journal-title":"Br J Surg"},{"key":"2024092716392967600_bib3","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/S0016-5085(82)80139-X","article-title":"Incidence and microbiology of abdominal and pelvic abscess in Crohn's disease","volume":"83","author":"Keighley","year":"1983","journal-title":"Gastroenterology"},{"key":"2024092716392967600_bib4","first-page":"293","volume-title":"Gastrointestinal Pathology","author":"Morson","year":"1979","edition":"2nd"},{"key":"2024092716392967600_bib5","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1136\/gut.19.12.1099","article-title":"Influence of inflammatory bowel disease on intestinal flora","volume":"19","author":"Keighley","year":"1978","journal-title":"Gut"},{"key":"2024092716392967600_bib6","first-page":"681","article-title":"Changes in intestinal microflora in Crohn's disease","volume":"69","author":"Ambrose","year":"1982","journal-title":"Br J Surg"},{"key":"2024092716392967600_bib7","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/bjs.1800640505","article-title":"Prevention of wound sepsis in gastrointestinal surgery","volume":"64","author":"Keighley","year":"1977","journal-title":"Br J Surg"},{"key":"2024092716392967600_bib8","first-page":"486","article-title":"New invasive assessment of small intestinal damage in Crohn's disease and ulcerative colitis","volume":"24","author":"de Gomes","year":"1983","journal-title":"Gut"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800710821","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/71\/8\/623\/59378279\/bjs1800710821.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/71\/8\/623\/59378279\/bjs1800710821.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T16:39:41Z","timestamp":1727455181000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/71\/8\/623\/6181579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,8,1]]},"references-count":8,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1984,8,1]]},"published-print":{"date-parts":[[1984,8,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800710821","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1984,8]]},"published":{"date-parts":[[1984,8,1]]}}}