{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T16:23:35Z","timestamp":1759335815749},"reference-count":32,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[1984,9,1]],"date-time":"1984-09-01T00:00:00Z","timestamp":462844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Peritoneal infection progresses through defined stages: contamination, inflammation and abscess formation. An experimental model of established peritonitis without adjuvant in the rat was used to test the effect of various local and systemic agents on survival. There was significant improvement in all treatment groups except those treated with antiseptic lavage using PVP-I and noxythiolin. Intramuscular ampicillin improved survival from 40 to 60 per cent while intramuscular amikacin combined with local irrigation with metronidazole reduced mortality to nil (P &amp;lt;0\u00b7001). Both cephradine and metronidazole used as peritoneal lavage solutions improved survival (P &amp;lt;0\u00b7005) when compared with the controls but the difference was not significant when compared with irrigation with Hartmann's solution. Metronidazole given rectally also improved survival from 40 to 60 per cent but this difference was not significant. We conclude that survival in established peritonitis depends upon adequate antibiotic therapy.<\/jats:p>","DOI":"10.1002\/bjs.1800710925","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T01:04:24Z","timestamp":1172883864000},"page":"715-717","source":"Crossref","is-referenced-by-count":10,"title":["Towards a rational approach to the treatment of peritonitis: An experimental study in rats"],"prefix":"10.1093","volume":"71","author":[{"given":"D J","family":"McAvinchey","sequence":"first","affiliation":[{"name":"Department of Surgery, St Laurence's Hospital , Dublin 7,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P T","family":"McCollum","sequence":"additional","affiliation":[{"name":"Department of Surgery, St Laurence's Hospital , Dublin 7,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Lynch","sequence":"additional","affiliation":[{"name":"Department of Surgery, St Laurence's Hospital , Dublin 7,","place":["Ireland"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1984,9,1]]},"reference":[{"key":"2024092716422144900_bib1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0011-3840(79)80011-8","article-title":"Secondary bacterial peritonitis: the biological basis of treatment","volume":"10","author":"Hau","year":"1979","journal-title":"Curr Probl Surg"},{"key":"2024092716422144900_bib2","first-page":"231","article-title":"Generalized infective peritonitis","volume":"147","author":"Stephen","year":"1978","journal-title":"Surg Gynecol Obstet"},{"key":"2024092716422144900_bib3","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1001\/archsurg.1983.01390030017003","article-title":"Prognosis in generalized peritonitis; relation to cause and risk factors","volume":"118","author":"Bohnen","year":"1983","journal-title":"Arch Surg"},{"key":"2024092716422144900_bib4","first-page":"1402","volume-title":"Principles of Surgery","author":"Condon","year":"1979","edition":"3rd"},{"key":"2024092716422144900_bib5","first-page":"777","article-title":"Generalized peritonitis; a continuing challenge","volume":"86","author":"Polk","year":"1979","journal-title":"Surgery"},{"key":"2024092716422144900_bib6","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1097\/00000658-198206000-00009","article-title":"Pulmonary infection complicating intra-abdominal sepsis","volume":"195","author":"Richardson","year":"1982","journal-title":"Ann Surg"},{"key":"2024092716422144900_bib7","first-page":"113","article-title":"Glucocorticoid action on rate glycolytic intermediates during experimental peritonitis","volume":"5","author":"Apantaku","year":"1981","journal-title":"Adv Shock Res"},{"key":"2024092716422144900_bib8","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1002\/bjs.1800700307","article-title":"Antiseptics in the treatment of bacterial peritonitis in rats","volume":"70","author":"McAvinchey","year":"1983","journal-title":"Br J Surg"},{"key":"2024092716422144900_bib9","first-page":"254","article-title":"The use of continuous postoperative peritoneal lavage in the management of diffuse peritonitis","volume":"130","author":"McKenna","year":"1970","journal-title":"Surg Gynecol Obstet"},{"key":"2024092716422144900_bib10","first-page":"73","article-title":"Clinical evaluation of peritoneal irrigation with antibiotic solution","volume":"62","author":"Noon","year":"1967","journal-title":"Surgery"},{"key":"2024092716422144900_bib11","first-page":"482","article-title":"The clinical use of intraperitoneal cephalothin","volume":"67","author":"McMullan","year":"1970","journal-title":"Surgery"},{"key":"2024092716422144900_bib12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1001\/archsurg.1982.01380260075013","article-title":"Generalized peritonitis. 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