{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T17:14:54Z","timestamp":1776878094320,"version":"3.51.2"},"reference-count":14,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[1984,11,1]],"date-time":"1984-11-01T00:00:00Z","timestamp":468115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1984,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The prophylactic effect of a semisynthetic heparin analogue (SSHA) on deep vein thrombosis was investigated in a prospective double-blind multicentre trial. 440 major general surgical and gynaecological patients were randomized to one of three treatment groups: 50 mg SSHA, 37\u00b75 mg SSHA and 5000 units sodium heparin subcutaneously 12-hourly. Deep venous thrombosis (DVT) was diagnosed with the fibrinogen uptake test and verified with phlebography. Bleeding complications and other side-effects were carefully monitored. There were no significant differences between the three treatment groups of patients in age, sex, type of operation or risk factors. A DVT was diagnosed in 16 patients (12 per cent) in the SSHA 50 mg group, in 21 patients (15 per cent) in the SSHA 37\u00b75 mg group and 21 patients (14 per cent) in the heparin-treated group. No significant differences were found in the number of patients who bled unexpectedly in the postoperative period, required transfusion or developed wound haematomas. Blood loss at operation was similar in all three groups. Three pulmonary emboli were diagnosed by pulmonary scintigraphy, one in each group.<\/jats:p>","DOI":"10.1002\/bjs.1800711102","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T00:21:57Z","timestamp":1172881317000},"page":"817-820","source":"Crossref","is-referenced-by-count":9,"title":["A randomized study of a semisynthetic heparin analogue and heparin in prophylaxis of deep vein thrombosis"],"prefix":"10.1093","volume":"71","author":[{"given":"S","family":"T\u00f6rngren","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Kettunen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Lahtinen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Koppenhagen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Br\u00fccke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P","family":"Hartl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O","family":"Hutter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"U","family":"Haller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Lahnborg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Forssk\u00e5hl","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1984,11,1]]},"reference":[{"key":"2024092721350642500_bib1","first-page":"45","article-title":"Prevention of fatal postoperative pulmonary embolism by low doses of heparin","volume":"ii","author":"An International Multicentre Trial","year":"1975","journal-title":"Lancet"},{"key":"2024092721350642500_bib2","doi-asserted-by":"crossref","first-page":"1980","DOI":"10.1001\/jama.1976.03260440032018","article-title":"Prevention of venous thrombosis with small subcutaneous doses of heparin","volume":"235","author":"Gallus","year":"1976","journal-title":"JAMA"},{"key":"2024092721350642500_bib3","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/S0140-6736(72)91595-4","article-title":"Efficacy of low doses of heparin in prevention of deep-vein thrombosis after major surgery","volume":"ii","author":"Kakkar","year":"1972","journal-title":"Lancet"},{"key":"2024092721350642500_bib4","first-page":"7","article-title":"Prophylaxis of postoperative thromboembolic complication with low-dose heparin. An analysis of different administration intervals","volume":"145","author":"Bergqvist","year":"1979","journal-title":"Acta Chir Scand"},{"key":"2024092721350642500_bib5","first-page":"87","article-title":"Optimal regimen of low dose heparin prophylaxis in gastrointestinal surgery","volume":"145","author":"T\u00f6rngren","year":"1979","journal-title":"Acta Chir Scand"},{"key":"2024092721350642500_bib6","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0140-6736(77)91708-1","article-title":"A heparin analogue with specific action on antithrombin III","volume":"i","author":"Thomas","year":"1977","journal-title":"Lancet"},{"key":"2024092721350642500_bib7","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0049-3848(78)90115-9","article-title":"A comparative study of low doses of heparin and a heparin analogue in the prevention of postoperative deep vein thrombosis","volume":"13","author":"Kakkar","year":"1978","journal-title":"Thromb Res"},{"key":"2024092721350642500_bib8","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1055\/s-0038-1653430","article-title":"In vivo studies on the inhibition of coagulation by fractionated heparin and by heparin analogue. II. Effects of a heparin analogue","volume":"46","author":"Schmitz-Huebner","year":"1981","journal-title":"Thromb Haemostas (Stuttgart)"},{"key":"2024092721350642500_bib9","first-page":"286","volume-title":"Haemostase, Thrombophilie und Arteriosklerose","author":"Haas","year":"1982"},{"key":"2024092721350642500_bib10","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1365-2141.1977.tb06840.x","article-title":"Comparison of heparin and a semisynthetic heparin analogue, A 73025. I. Kinetics of clearance from the circulation of man following intravenous injection","volume":"37","author":"Lane","year":"1977","journal-title":"Br J Haematol"},{"key":"2024092721350642500_bib11","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1111\/j.1365-2141.1977.tb06841.x","article-title":"Comparison of heparin and a semi-synthetic heparin analogue, A 73025. II. Some effects on platelet function","volume":"37","author":"Michalski","year":"1977","journal-title":"Br J Haematol"},{"key":"2024092721350642500_bib12","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1016\/0049-3848(83)90187-1","article-title":"Effects of heparin and a semisynthetic heparin analogue on platelet aggregation, lipoprotein lipase and other laboratory tests in surgical patients","volume":"30","author":"T\u00f6rngren","year":"1983","journal-title":"Thromb Res"},{"key":"2024092721350642500_bib13","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/0049-3848(82)90014-7","article-title":"Nature of the anti-Xa activity induced by a heparin analogue (SSHA) in vivo","volume":"27","author":"Schmitz-Huebner","year":"1982","journal-title":"Thromb Res"},{"key":"2024092721350642500_bib14","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/0049-3848(80)90248-0","article-title":"In vivo release of anti-Xa clotting activity by heparin analogue","volume":"17","author":"Thomas","year":"1980","journal-title":"Thromb Res"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800711102","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/71\/11\/817\/59377143\/bjs1800711102.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/71\/11\/817\/59377143\/bjs1800711102.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T21:35:16Z","timestamp":1727472916000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/71\/11\/817\/6186192"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,11,1]]},"references-count":14,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1984,11,1]]},"published-print":{"date-parts":[[1984,11,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800711102","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1984,11]]},"published":{"date-parts":[[1984,11,1]]}}}