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In order to evaluate their role in the identification of patients with significant arterial lesions, these measurements were correlated with the angiographic appearances, the clinical picture and the presence or absence of infarction on CT scan. Patients with carotid stenosis of 60 per cent or more had normal resting flows, but reduced responsiveness to CO2 inhalation. Patients with carotid occlusion had both reduced resting flow and reduced CO2 responsiveness. Infarcts were visible in 25 per cent of the hemispheres studied, and were more common in patients with fixed neurological deficits, but were also present in 17 per cent of patients with transient ischaemic attacks (TIAs). Reduction in the collateral supply from the contralateral carotid artery via the Circle of Willis further reduced CO2 responsiveness with ipsilateral internal carotid occlusion. The normal increase in CBF which occurs with the inhalation of carbon dioxide is diminished with increasingly severe bilateral disease, with infarction and with a fixed neurological deficit.<\/jats:p>","DOI":"10.1002\/bjs.1800720506","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T04:40:51Z","timestamp":1172896851000},"page":"348-351","source":"Crossref","is-referenced-by-count":93,"title":["Cerebral blood flow and CO2 responsiveness as an indicator of collateral reserve capacity in patients with carotid arterial disease"],"prefix":"10.1093","volume":"72","author":[{"given":"R","family":"Bullock","sequence":"first","affiliation":[{"name":"Institute of Neurological Sciences, University of Glasgow , Glasgow,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A D","family":"Mendelow","sequence":"additional","affiliation":[{"name":"Institute of Neurological Sciences, University of Glasgow , Glasgow,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I","family":"Bone","sequence":"additional","affiliation":[{"name":"Institute of Neurological Sciences, University of Glasgow , Glasgow,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Patterson","sequence":"additional","affiliation":[{"name":"Institute of Neurological Sciences, University of Glasgow , Glasgow,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W N","family":"Macleod","sequence":"additional","affiliation":[{"name":"Institute of Neurological Sciences, University of Glasgow , Glasgow,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G","family":"Allardice","sequence":"additional","affiliation":[{"name":"Institute of Neurological Sciences, University of Glasgow , Glasgow,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1985,5,1]]},"reference":[{"key":"2024092717124765700_bib1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/0022-510X(64)90052-8","article-title":"Thrombotic and embolic occlusions of the carotid arteries in autopsy material","volume":"1","author":"Torvik","year":"1964","journal-title":"J Neurol Sci"},{"volume-title":"\u00dcber Thrombose und Embolie der Arteria Carotidis und Hierbei Vorkommende Gehirnver\u00e4nderungen","year":"1942","author":"Hultquist","key":"2024092717124765700_bib2"},{"volume-title":"Cerebral Apoplexy: Types, Cases and Pathogenesis. 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