{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T15:03:37Z","timestamp":1791471817675,"version":"4.3.4"},"reference-count":21,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[1985,7,1]],"date-time":"1985-07-01T00:00:00Z","timestamp":489024000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1985,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Two hundred and fifty patients were admitted to a prospective randomized trial to compare the efficacy of Augmentin with metronidazole in the prevention of sepsis after appendicectomy. Pre-operatively they received either 500 mg metronidazole or 1\u00b72 g Augmentin intravenously. Those patients with gangrenous or perforated appendices received eight additional doses of the trial drug at 8 hourly intervals. Overall there were 13 wound infections in the Augmentin group (11 per cent) and 21 in the metronidazole group (18 per cent). The 90 per cent confidence limits for the overall 7 per cent difference in infection rates were \u00b18\u00b75 per cent. There were high rates of wound infection in the gangrenous group (Augmentin 8 per cent versus metronidazole 19 per cent) and especially in the perforated group (Augmentin 33 per cent versus metronidazole 63 per cent). There was no statistically significant difference between the infection rates with the two antibiotics but our study suggests that Augmentin, which is active against both aerobes and anaerobes, may be more effective than metronidazole in reducing wound sepsis after appendicectomy.<\/jats:p>","DOI":"10.1002\/bjs.1800720724","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T06:26:49Z","timestamp":1172903209000},"page":"571-573","source":"Crossref","is-referenced-by-count":20,"title":["Metronidazole and Augmentin in the prevention of sepsis after appendicectomy"],"prefix":"10.1093","volume":"72","author":[{"given":"J","family":"Drumm","sequence":"first","affiliation":[{"name":"Departments of Surgery and Microbiology, Dudley Road Hospital , Birmingham,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I A","family":"Donovan","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Microbiology, Dudley Road Hospital , Birmingham,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R","family":"Wise","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Microbiology, Dudley Road Hospital , Birmingham,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Lowe","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Microbiology, Dudley Road Hospital , Birmingham,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1985,7,1]]},"reference":[{"key":"2024092717444730500_bib1","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1136\/bmj.281.6255.1597","article-title":"Prophylaxis of infection after appendicectomy: a survey of current surgical practice","volume":"281","author":"Campbell","year":"1980","journal-title":"Br Med J"},{"key":"2024092717444730500_bib2","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1136\/bmj.285.6345.871","article-title":"Survey of antibiotic prophylaxis in gastrointestinal surgery in Scotland","volume":"285","author":"Wilson","year":"1982","journal-title":"Br Med J"},{"key":"2024092717444730500_bib3","first-page":"52","article-title":"Wound infections: a controlled clinical and experimental demonstration of synergy between aerobic E Coli and anaerobic B fragilis bacteria","volume":"62","author":"Kelly","year":"1980","journal-title":"Ann R Coll Surg Eng"},{"key":"2024092717444730500_bib4","first-page":"374","article-title":"The pathogenicity of the bacteria of appendicitis peritonitis: an experimental study","volume-title":"Surgery","author":"Altemeier","year":"1942"},{"key":"2024092717444730500_bib5","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1111\/j.1445-2197.1980.tb04158.x","article-title":"The prevention of post-appendicectomy sepsis by metronidazole and cefazolin: a controlled double-blind trial","volume":"50","author":"Morris","year":"1980","journal-title":"Aust N Z J Surg"},{"key":"2024092717444730500_bib6","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1002\/bjs.1800701110","article-title":"Prophylaxis of post-appendicectomy sepsis by metronidazole and cefotaxime: a randomized, prospective and double blind trial","volume":"70","author":"Lau","year":"1983","journal-title":"Br J Surg"},{"key":"2024092717444730500_bib7","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1002\/bjs.1800700306","article-title":"Prophylaxis of post-appendicectomy sepsis by metronidazole and ampicillin: a randomized, prospective and double-blind trial","volume":"70","author":"Lau","year":"1983","journal-title":"Br J Surg"},{"key":"2024092717444730500_bib8","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/0002-9610(82)90594-3","article-title":"Antibiotic management of surgically treated gangrenous and perforated appendicitis. Comparison of gentamicin and clindamycin versus cefamandole versus cefoperazone","volume":"144","author":"Berne","year":"1982","journal-title":"Am J Surg"},{"key":"2024092717444730500_bib9","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1007\/BF01653546","article-title":"Antimicrobial prophylaxis in appendicectomy patients","volume":"6","author":"Gottrup","year":"1982","journal-title":"World J Surg"},{"key":"2024092717444730500_bib10","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF01655054","article-title":"Wound infections in appendicitis: effective prophylaxis","volume":"8","author":"Gaffney","year":"1984","journal-title":"World J Surg"},{"key":"2024092717444730500_bib11","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1002\/bjs.1800660317","article-title":"One dose antibiotic prophylaxis against wound infection after appendicectomy: a randomized trial of clindamycin, cefazolin sodium and a 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