{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:58:10Z","timestamp":1787313490402,"version":"build-2736575974"},"reference-count":17,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[1985,11,1]],"date-time":"1985-11-01T00:00:00Z","timestamp":499651200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust Research","doi-asserted-by":"publisher","award":["12196 14L"],"award-info":[{"award-number":["12196 14L"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1985,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Continuous fluid-inflation proctometrograms were performed in men with the symptoms of chronic radiation proctitis and in age and sex-matched control subjects (n = 10). Rectal volumes and compliance were measured. There was a significant reduction in the rectal volumes at sensory threshold, constant sensation and maximal tolerance and in rectal compliance (P&amp;lt;0.01). Comparable pressure measurements did not demonstrate significant differences. The maximum tolerable volume, symptomatic and sigmoidoscopic scoring correlated to rectal compliance (r = 0.77, \u22120.8, \u22120.73; P&amp;lt;0.01, &amp;lt;0.01, &amp;lt;0.02, respectively). Reduction in volume and compliance is often not obvious radiologically. Histological evidence suggests that smooth muscle hypertrophy and myenteric plexus damage are contributory.<\/jats:p>","DOI":"10.1002\/bjs.1800721107","type":"journal-article","created":{"date-parts":[[2007,3,2]],"date-time":"2007-03-02T23:27:49Z","timestamp":1172878069000},"page":"875-878","source":"Crossref","is-referenced-by-count":126,"title":["Correlation of clinical and manometric abnormalities of rectal function following chronic radiation injury"],"prefix":"10.1093","volume":"72","author":[{"given":"J S","family":"Varma","sequence":"first","affiliation":[{"name":"University Department of Surgery\/Urology, Wolfson Gastrointestinal Laboratory and Department of Pathology, Western General Hospital , Edinburgh EH4 2XU,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A N","family":"Smith","sequence":"additional","affiliation":[{"name":"University Department of Surgery\/Urology, Wolfson Gastrointestinal Laboratory and Department of Pathology, Western General Hospital , Edinburgh EH4 2XU,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Busuttil","sequence":"additional","affiliation":[{"name":"University Department of Surgery\/Urology, Wolfson Gastrointestinal Laboratory and Department of Pathology, Western General Hospital , Edinburgh EH4 2XU,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1985,11,1]]},"reference":[{"key":"2024092717242683200_bib1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1002\/bjs.1800690906","article-title":"MRC Working Party. 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