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A functional disorder of the hypothalamopituitary axis was found in 13 patients with hidradenitis when compared with 9 controls. In response to a combined thyrotrophin releasing hormone and gonadotrophin releasing hormone test, the prolactin and TSH responses were significantly greater in the hidradenitis patients than the controls. No significant differences were found in the mean basal levels of oestrogen, progesterone, testosterone, dehydroepiandrosterone sulphate, T3 and T4. These results may reflect a disturbance of feedback signals from peripheral hormones, rather than a primary dysfunction of the control of specific anterior pituitary cells.<\/jats:p>","DOI":"10.1002\/bjs.1800721223","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T03:48:19Z","timestamp":1172893699000},"page":"1002-1004","source":"Crossref","is-referenced-by-count":52,"title":["Hidradenitis suppurativa: evidence for an endocrine abnormality"],"prefix":"10.1093","volume":"72","author":[{"given":"B J","family":"Harrison","sequence":"first","affiliation":[{"name":"Department of Surgery, University of Wales College of Medicine ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Wales College of Medicine ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G F","family":"Read","sequence":"additional","affiliation":[{"name":"Tenovus Institute, Heath Park , Cardiff,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Catherine A","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wales College of Medicine ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M F","family":"Scanlon","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Wales College of Medicine ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L E","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of Wales College of Medicine ,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1985,12,1]]},"reference":[{"key":"2024092717125514400_bib1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1001\/archderm.1955.03730360068008","article-title":"The pathogenesis of hidradenitis suppurativa in man: experimental and histological observations","volume":"72","author":"Shelley","year":"1955","journal-title":"AMA Arch Dermat"},{"key":"2024092717125514400_bib2","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1001\/archderm.1952.01530220044004","article-title":"Hidradenitis and other variants of acne","volume":"65","author":"Brunsting","year":"1952","journal-title":"AMA Arch Dermat Syph"},{"key":"2024092717125514400_bib3","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1159\/000251048","article-title":"Untersuchungen zur Wirkung der Vitamin-A-Saure bei experimentell augeloster Follikelkeratose","volume":"153","author":"Kroepfli","year":"1976","journal-title":"Dermatologica"},{"key":"2024092717125514400_bib4","first-page":"331","article-title":"Hidradenitis suppurativa of the perineum: treatment by radical excision","volume":"36","author":"Chalfant","year":"1970","journal-title":"Am Surg"},{"key":"2024092717125514400_bib5","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/BF02616510","article-title":"Perianal hidradenitis suppurativa. 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