{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T14:57:15Z","timestamp":1761058635091},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[1986,3,1]],"date-time":"1986-03-01T00:00:00Z","timestamp":510019200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The findings of 27 lymph node biopsies performed on 24 homosexual patients with lymphadenopathy are presented. Six had acquired immune deficiency syndrome (AIDS) and 18 lymphadenopathy only, of whom one subsequently developed AIDS. All these patients had antibodies to the human T-cell lymphotropic virus type III (HTLV-III) suggesting that HTLV-III is currently the commonest cause of lymphadenopathy in homosexual men. The histopathological findings of six of seven nodes from AIDS patients showed either follicular depletion alone or follicular and paracortical lymphocyte depletion. Nodes from four patients showed Kaposi's sarcoma, three of which also showed follicular hyperplasia. In two of these patients there were no cutaneous manifestations of this condition. One lymph node from a patient with persistent generalized lymphadenopathy (PGL) showed Mycobacterium tuberculosis. Six nodes from six other patients have had features oftoxoplasmosis although there was no serological or clinical evidence of recent toxoplasma infection. The remaining 11 lymph nodes from patients with PGL and one node from a patient with transient lymphadenopathy, showed reactive follicular hyperplasia only. We conclude that homosexuals with lymphadenopathy who are HTLV-III antibody positive do not need a routine node biopsy unless an alternative diagnosis is strongly suspected.<\/jats:p>","DOI":"10.1002\/bjs.1800730307","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T06:49:28Z","timestamp":1172904568000},"page":"180-182","source":"Crossref","is-referenced-by-count":17,"title":["Clinical investigations of lymphadenopathy, including lymph node biopsies, in 24 homosexual men with antibodies to the human T-cell lymphotropic virus type III (HTLV-III)"],"prefix":"10.1093","volume":"73","author":[{"given":"C F","family":"Farthing","sequence":"first","affiliation":[{"name":"St. Stephen's, and the Charing Cross , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristin","family":"Henry","sequence":"additional","affiliation":[{"name":"Westminster Medical School , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D C","family":"Shanson","sequence":"additional","affiliation":[{"name":"St. Stephen's, and the Charing Cross , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Taube","sequence":"additional","affiliation":[{"name":"St. Stephen's, and the Charing Cross , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A G","family":"Lawrence","sequence":"additional","affiliation":[{"name":"St. Stephen's, and the Charing Cross , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J N","family":"Harcourt-Webster","sequence":"additional","affiliation":[{"name":"St. Stephen's, and the Charing Cross , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B","family":"Gazzard","sequence":"additional","affiliation":[{"name":"St. Stephen's, and the Charing Cross , London,","place":["UK"]},{"name":"Westminster Hospitals and the Charing Cross , London,","place":["UK"]},{"name":"Westminster Medical School , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1986,3,1]]},"reference":[{"key":"2024100215142951800_bib1","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/S0140-6736(84)92562-5","article-title":"Prevalence of antibody to human T-lymphotropic virus type III in AIDS and AIDS-risk patients in Britain","volume":"ii","author":"Cheingsong-Popov","year":"1984","journal-title":"Lancet"},{"key":"2024100215142951800_bib2","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1016\/S0140-6736(84)92563-7","article-title":"Clinical findings and serological evidence of HTLV-III infection in homosexual contacts of patients with AIDS and persistent generalised lymphadenopathy in London","volume":"ii","author":"Gazzard","year":"1984","journal-title":"Lancet"},{"key":"2024100215142951800_bib3","first-page":"249","article-title":"Persistent generalised lymphadenopathy among homosexual males","volume":"31","author":"Centre for Disease Control.","year":"1982","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"2024100215142951800_bib4","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1136\/bmj.290.6476.1176","article-title":"Prevalence of antibody to human T lymphotropic virus type III by risk group and area, United Kingdom 1978\u201384","volume":"290","author":"Mortimer","year":"1985","journal-title":"Br Med J"},{"key":"2024100215142951800_bib5","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1093\/infdis\/145.4.586","article-title":"Disseminated infection due to Mycobacterium avium intracellulare in a homosexual man with Kaposi's sarcoma","volume":"145","author":"Fainstein","year":"1982","journal-title":"J Infect Dis"},{"key":"2024100215142951800_bib6","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1001\/jama.1983.03340100047028","article-title":"Value of lymph node biopsy in unexplained lymphadenopathy in homosexual men","volume":"250","author":"Byrnes","year":"1983","journal-title":"JAMA"},{"key":"2024100215142951800_bib7","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/path.1711430402","article-title":"AIDS: histopathological aspects","volume":"143","author":"Millard","year":"1984","journal-title":"J Path"},{"key":"2024100215142951800_bib8","first-page":"1376","article-title":"Editorial. 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