{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,28]],"date-time":"2024-09-28T04:26:16Z","timestamp":1727497576857},"reference-count":39,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1986,4,1]],"date-time":"1986-04-01T00:00:00Z","timestamp":512697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Between 1971 and 1983, 31 males and 13 females were found to have peptic ulceration associated with hypergastrinaemia. An antral G-cell lesion was present in 11 (25 per cent) and a gastrinoma in 14 (32 per cent). There were 11 patients with multiple endocrine adenomatosis (MEA) (25 per cent) and 4 (9 per cent) with primary hyperparathyroidism. Four patients (9 per cent) were unclassified. Length of history and level of gastrin did not differentiate between the groups and an average of 2\u00b75 operations was performed per patient, while the overall mortality was 27\u00b73 per cent. The patients with G-cell lesions were significantly younger than all the other groups (P &amp;lt;0\u00b701). Partial gastrectomy adequately treated G-cell hyperplasia. Total gastrectomy was required to treat pancreatic gastrinomata but additional pancreatic resection did not improve the outcome. In MEA, parathyroidectomy did not influence the treatment of a gastrinoma. This is the first recorded experience of surgery for hypergastrinaemia in the United Kingdom and the outcome of such a retrospective study may be a guide to the future management of these conditions.<\/jats:p>","DOI":"10.1002\/bjs.1800730403","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T06:49:10Z","timestamp":1172904550000},"page":"248-252","source":"Crossref","is-referenced-by-count":2,"title":["Surgery for peptic ulceration associated with hypergastrinaemia"],"prefix":"10.1093","volume":"73","author":[{"given":"C G","family":"Clark","sequence":"first","affiliation":[{"name":"Department of Surgery, Faculty of Clinical Sciences, University College London , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N L","family":"Chowcat","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Clinical Sciences, University College London , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M R","family":"Lewin","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Clinical Sciences, University College London , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Gilbert","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Clinical Sciences, University College London , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J S K","family":"Gelister","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Clinical Sciences, University College London , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P B","family":"Boulos","sequence":"additional","affiliation":[{"name":"Department of Surgery, Faculty of Clinical Sciences, University College London , London,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1986,4,1]]},"reference":[{"key":"2024092718233697300_bib1","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1097\/00000658-195510000-00015","article-title":"Primary peptic ulcerations of the jejunum associated with islet cell tumours of the pancreas","volume":"142","author":"Zollinger","year":"1955","journal-title":"Ann Surg"},{"key":"2024092718233697300_bib2","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S0300-5089(21)00617-9","article-title":"Gastrointestinal hormones in the pathogenesis of peptic ulcer disease","volume":"13","author":"Taylor","year":"1984","journal-title":"Clin Gastroenterol"},{"key":"2024092718233697300_bib3","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1136\/gut.13.11.887","article-title":"Gastrin and acid secretion after food, meat extract and insulin","volume":"13","author":"Wyllie","year":"1972","journal-title":"Gut"},{"key":"2024092718233697300_bib4","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/BF01654904","article-title":"Thirty years' experience with gastrinoma","volume":"8","author":"Zollinger","year":"1984","journal-title":"World J Surg"},{"key":"2024092718233697300_bib5","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1097\/00000658-198305000-00014","article-title":"The role of surgery in the Zollinger-Ellison syndrome","volume":"197","author":"Thompson","year":"1983","journal-title":"Ann Surg"},{"key":"2024092718233697300_bib6","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1097\/00000658-198112000-00005","article-title":"Results of surgical management in 92 consecutive patients with Zollinger-Ellison syndrome","volume":"194","author":"Bonfils","year":"1981","journal-title":"Ann Surg"},{"key":"2024092718233697300_bib7","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1016\/0016-5085(83)90375-X","article-title":"Medical and surgical options in the management of patients with gastrinoma","volume":"84","author":"Malagelada","year":"1983","journal-title":"Gastroenterology"},{"key":"2024092718233697300_bib8","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1097\/00000658-198310000-00015","article-title":"Resection of gastrinomas","volume":"198","author":"Deveney","year":"1983","journal-title":"Ann Surg"},{"key":"2024092718233697300_bib9","doi-asserted-by":"crossref","first-page":"59","DOI":"10.7326\/0003-4819-98-1-59","article-title":"Zollinger-Ellison syndrome: current concepts and management","volume":"98","author":"Jensen","year":"1983","journal-title":"Ann of Int Med"},{"key":"2024092718233697300_bib10","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0002-9610(82)90102-7","article-title":"Treatment of the Zollinger-Ellison syndrome. A 25 year assessment","volume":"143","author":"Friesen","year":"1982","journal-title":"Am J Surg"},{"key":"2024092718233697300_bib11","first-page":"79","article-title":"The clinical diagnosis of the Zollinger-Ellison syndrome","volume-title":"Scand J Gastroenterology","author":"Stage","year":"1979"},{"key":"2024092718233697300_bib12","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1136\/gut.13.7.501","article-title":"Two types of Zollinger-Ellison syndrome: immunofluorescent, cytochemical and ultrastructural studies of the antral and pancreatic gastrin cells in different clinical states","volume":"13","author":"Polack","year":"1972","journal-title":"Gut"},{"key":"2024092718233697300_bib13","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1097\/00000478-198411000-00002","article-title":"Primary gastrin cell hyperplasia","volume":"8","author":"Lewin","year":"1984","journal-title":"Am J Surg Path"},{"key":"2024092718233697300_bib14","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3109\/00365528509089663","article-title":"Frequency of endocrine disorders in patients with the Zollinger-Ellison syndrome","volume":"20","author":"Bardram","year":"1985","journal-title":"Scand J Gastroenterol"},{"key":"2024092718233697300_bib15","first-page":"177","article-title":"Islet cell tumours and the ulcerogenic syndrome","volume":"21","author":"McGuigan","year":"1980","journal-title":"Monographs in Path"},{"key":"2024092718233697300_bib16","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1002\/bjs.1800541006","article-title":"An assessment of postoperative testing for completeness of vagotomy","volume":"54","author":"Johnston","year":"1967","journal-title":"Br J Surg"},{"key":"2024092718233697300_bib17","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0016-5085(74)80073-9","article-title":"Gastrin response to insulin after selective, highly selective and truncal vagotomy","volume":"66","author":"Stadil","year":"1974","journal-title":"Gastroenterology"},{"key":"2024092718233697300_bib18","first-page":"848","article-title":"Vagotomy and gastrin secretion","volume":"13","author":"Byrnes","year":"1972","journal-title":"Gut"},{"key":"2024092718233697300_bib19","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1007\/BF01654771","article-title":"Effect of vagotomy on gastrointestinal hormones","volume":"3","author":"Becker","year":"1979","journal-title":"World J Surg"},{"key":"2024092718233697300_bib20","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1177\/003693308302800403","article-title":"The prevalence of gastrinomas in recurrent peptic ulceration","volume":"28","author":"Primrose","year":"1983","journal-title":"Scott Med J"},{"key":"2024092718233697300_bib21","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1007\/BF01654936","article-title":"Further experience with pseudo-Zollinger-Ellison syndrome: its place in the management of neuroendocrine duodenal ulceration","volume":"8","author":"Friesen","year":"1984","journal-title":"World J Surg"},{"key":"2024092718233697300_bib22","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/0016-5085(80)90933-6","article-title":"Secretin injection test in the diagnosis of gastrinoma","volume":"79","author":"McGuigan","year":"1980","journal-title":"Gastroenterology"},{"key":"2024092718233697300_bib23","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1097\/00000658-198003000-00004","article-title":"Antral gastrin cell hyperplasia in patients with peptic ulcer","volume":"191","author":"Kueppens","year":"1980","journal-title":"Ann Surg"},{"key":"2024092718233697300_bib24","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1016\/0016-5085(78)90313-X","article-title":"Secretin, gastrin, gastrinoma and hyperparathyroidism","volume":"74","author":"Lamers","year":"1978","journal-title":"Gastroenterology"},{"key":"2024092718233697300_bib25","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1097\/00000658-198410000-00002","article-title":"Removal of gastrinomas for control of Zollinger-Ellison syndrome","volume":"200","author":"Harmon","year":"1984","journal-title":"Ann Surg"},{"key":"2024092718233697300_bib26","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/0016-5085(85)90337-3","article-title":"Treatment of Zollinger-Ellison syndrome with exploratory laparotomy, proximal gastric vagotomy and H2-receptor antagonists","volume":"89","author":"Richardson","year":"1985","journal-title":"Gastroenterology"},{"key":"2024092718233697300_bib27","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/0016-5085(78)90780-1","article-title":"Report on the United States experience with cimetidine in Zollinger-Ellison syndrome and other hypersecretory states","volume":"74","author":"McCarthy","year":"1978","journal-title":"Gastroenterology"},{"key":"2024092718233697300_bib28","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/0002-9610(83)90160-5","article-title":"Failure of histamine H2-receptor antagonist therapy in Zollinger-Ellison syndrome","volume":"145","author":"Stabile","year":"1983","journal-title":"Am J Surg"},{"key":"2024092718233697300_bib29","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1056\/NEJM198403223101205","article-title":"Omeprazole in Zollinger-Ellison syndrome","volume":"310","author":"Lamers","year":"1984","journal-title":"N Engl J Med"},{"key":"2024092718233697300_bib30","first-page":"63","volume-title":"Cimetidine in the 80's","author":"Stage","year":"1981"},{"key":"2024092718233697300_bib31","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1007\/BF01654767","article-title":"Cimetidine treatment of acute and chronic Zollinger-Ellison syndrome","volume":"3","author":"Bonfils","year":"1979","journal-title":"World J Surg"},{"key":"2024092718233697300_bib32","doi-asserted-by":"crossref","first-page":"1026","DOI":"10.1016\/S0016-5085(85)80024-X","article-title":"Famotidine, a new potent, long-acting histamine H2-receptor antagonist: comparison with cimetidine and ranitidine in the treatment of Zollinger-Ellison syndrome","volume":"88","author":"Howard","year":"1985","journal-title":"Gastroenterology"},{"key":"2024092718233697300_bib33","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1056\/NEJM198304143081508","article-title":"Cimetidine-induced impotence and breast changes in patients with gastric hypersecretory states","volume":"308","author":"Jensen","year":"1983","journal-title":"N Engl J Med"},{"key":"2024092718233697300_bib34","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1136\/pgmj.60.709.767","article-title":"Gastrins and gastrinomas","volume":"60","author":"Hansky","year":"1984","journal-title":"Postgrad Med J"},{"key":"2024092718233697300_bib35","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/S0016-5085(19)33157-9","article-title":"Zollinger-Ellison syndrome","volume":"65","author":"Isenberg","year":"1973","journal-title":"Gastroenterology"},{"key":"2024092718233697300_bib36","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1016\/0016-5085(79)90350-0","article-title":"Zollinger-Ellison syndrome with diarrhoea as the predominant clinical feature","volume":"76","author":"Fang","year":"1979","journal-title":"Gastroenterology"},{"key":"2024092718233697300_bib37","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/S0002-9610(85)80024-6","article-title":"Benign and malignant gastrinoma","volume":"149","author":"Stabile","year":"1985","journal-title":"Am J Surg"},{"key":"2024092718233697300_bib38","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1136\/gut.26.5.433","article-title":"New somatostatin molecule for management of endocrine tumours","volume":"26","author":"Bonfils","year":"1985","journal-title":"Gut"},{"key":"2024092718233697300_bib39","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1136\/gut.26.5.438","article-title":"Treatment of patients with pancreatic endocrine tumours using a new long-acting somatostatin analogue symptomatic and peptide responses","volume":"26","author":"Wood","year":"1985","journal-title":"Gut"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800730403","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/73\/4\/248\/59382080\/bjs1800730403.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/73\/4\/248\/59382080\/bjs1800730403.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T18:23:57Z","timestamp":1727461437000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/73\/4\/248\/6182831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,4,1]]},"references-count":39,"journal-issue":{"issue":"4","published-online":{"date-parts":[[1986,4,1]]},"published-print":{"date-parts":[[1986,4,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800730403","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"type":"print","value":"0007-1323"},{"type":"electronic","value":"1365-2168"}],"subject":[],"published-other":{"date-parts":[[1986,4]]},"published":{"date-parts":[[1986,4,1]]}}}