{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T01:24:37Z","timestamp":1790731477883,"version":"4.1.0"},"reference-count":28,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1986,4,1]],"date-time":"1986-04-01T00:00:00Z","timestamp":512697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Following laparotomy for severe intra-abdominal sepsis, the abdominal cavity was left open to heal by granulation in 18 patients. In 14 patients, operation was required because of recurrent gastrointestinal perforation or anastomotic dehiscence. In three, the indication for this procedure was recurrent pancreatic abscess. Of the 17, 13 had previously undergone multiple operations which had failed to control sepsis. Laparostomy was performed as a primary procedure in only one case, a patient with fulminating pancreatitis requiring pancreatic necrosectomy. All patients received parenteral nutrition. The overall mortality was 28 per cent. However, there was only one death among the last 9 patients treated compared with 4 in the previous 9. The median sepsis score in the first 9 (19, range 10\u201326) was not significantly different (P &amp;gt; 0\u00b705)from that in the subsequent 9 patients (17, range 8\u201321). Three of the four who had initially presented with severe acute pancreatitis died. No patient eviscerated and only 9 (50 per cent) required mechanical ventilation for a median duration of 5 days. The median time for wound healing was 10 weeks and 6 patients have subsequently undergone definitive surgery with satisfactory results. Laparostomy is a valuable technique in the management of severe, intractable intra-abdominal sepsis.<\/jats:p>","DOI":"10.1002\/bjs.1800730405","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T06:49:10Z","timestamp":1172904550000},"page":"253-259","source":"Crossref","is-referenced-by-count":74,"title":["\u2018Laparostomy\u2019: A technique for the management of intractable intra-abdominal sepsis"],"prefix":"10.1093","volume":"73","author":[{"given":"M M","family":"Mughal","sequence":"first","affiliation":[{"name":"Department of Surgery, Hope Hospital (University of Manchester School of Medicine) , Eccles Old Road, Salford M6 8HD,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Bancewicz","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hope Hospital (University of Manchester School of Medicine) , Eccles Old Road, Salford M6 8HD,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M H","family":"Irving","sequence":"additional","affiliation":[{"name":"Department of Surgery, Hope Hospital (University of Manchester School of Medicine) , Eccles Old Road, Salford M6 8HD,","place":["UK"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1986,4,1]]},"reference":[{"key":"2024092718185703700_bib1","first-page":"231","article-title":"Generalized infective peritonitis","volume":"147","author":"Stephen","year":"1978","journal-title":"Surg Gynecol Obstet"},{"key":"2024092718185703700_bib2","volume-title":"Re-operation for Abdominal Sepsis","author":"Aeberhard","year":"1983"},{"key":"2024092718185703700_bib3","first-page":"99","article-title":"Prevention, diagnosis and treatment of pancreatic abscess","volume":"82","author":"Ranson","year":"1977","journal-title":"Surgery"},{"key":"2024092718185703700_bib4","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1002\/bjs.1800650115","article-title":"Peritoneal lavage in appendicular peritonitis","volume":"65","author":"Stewart","year":"1978","journal-title":"Br J Surg"},{"key":"2024092718185703700_bib5","first-page":"254","article-title":"The use of continuous postoperative peritoneal lavage in the management of diffuse peritonitis","volume":"130","author":"McKenna","year":"1970","journal-title":"Surg Gynecol Obstet"},{"key":"2024092718185703700_bib6","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/BF02629531","article-title":"Continuous postoperative lavage in the treatment of peritoneal sepsis","volume":"25","author":"Jennings","year":"1982","journal-title":"Dis Colon Rectum"},{"key":"2024092718185703700_bib7","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1001\/archsurg.1975.01360160071012","article-title":"Radical surgical debridement in the treatment of advanced generalised peritonitis","volume":"110","author":"Hudspeth","year":"1974","journal-title":"Arch Surg"},{"key":"2024092718185703700_bib8","first-page":"350","article-title":"Radical peritoneal debridement for established peritonitis. 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