{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T03:47:26Z","timestamp":1754020046819},"reference-count":18,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1986,4,1]],"date-time":"1986-04-01T00:00:00Z","timestamp":512697600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Duodenogastric bile reflux (DGBR) is reported to be increased in patients with gastric ulcer (GU) and following Billroth I partial gastrectomy (BIPG). pH, total bacterial counts, and total and free bile acids were measured in gastric juice aspirated hourly for 24 h in 6 patients with GU, 7 patients with a BIPG performed for GU and in 8 healthy normal controls. Intragastric pH was significantly higher in the BI PG group during the day (P &amp;lt; 0\u00b7001) and at night (P &amp;lt; 0\u00b7001) compared with normals and the GU group. There were no differences between GUs and normal patients. Bile acid concentrations in the gastric juice were not significantly different between GU and control groups over the 24 h. Median and range values were 0\u00b714 (0\u00b706\u20130\u00b752) mmol l\u22121 in GU patients and 0\u00b714 (0\u00b705\u20130\u00b767) mmol l\u22121 in the normals. However total bile acid concentrations were significantly greater in the BIPG group (0\u00b723, 0\u00b704\u20130\u00b784) compared with GU or controls. (P = 0\u00b704, P = 0\u00b702). Our data do not support the role of DGBR in the pathogenesis of GU, but deoxycholic acid was detected in significantly greater amounts in BIPG subjects than controls (\u03c72 = 12\u00b794, P &amp;lt;0\u00b7001) or GU subjects (none detected) and may be important in the pathogenesis of gastric stump cancer.<\/jats:p>","DOI":"10.1002\/bjs.1800730416","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T06:49:10Z","timestamp":1172904550000},"page":"295-297","source":"Crossref","is-referenced-by-count":13,"title":["Incidence of bile reflux in gastric ulcer and after partial gastrectomy"],"prefix":"10.1093","volume":"73","author":[{"given":"Valerie","family":"Poxon","sequence":"first","affiliation":[{"name":"Department of Surgery, The General Hospital , Birmingham,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Hogg","sequence":"additional","affiliation":[{"name":"Department of Surgery, The General Hospital , Birmingham,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denise","family":"Youngs","sequence":"additional","affiliation":[{"name":"Department of Surgery, The General Hospital , Birmingham,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D L","family":"Morris","sequence":"additional","affiliation":[{"name":"Department of Surgery, The General Hospital , Birmingham,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M R B","family":"Keighley","sequence":"additional","affiliation":[{"name":"Department of Surgery, The General Hospital , Birmingham,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1986,4,1]]},"reference":[{"key":"2024092718173481000_bib1","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1016\/S0140-6736(65)91214-6","article-title":"Pathogenesis of gastric ulceration","volume":"1","author":"DuPlessis","year":"1965","journal-title":"Lancet"},{"key":"2024092718173481000_bib2","first-page":"21","article-title":"Factors in the pathogenesis of gastric ulcer","volume":"40","author":"Capper","year":"1967","journal-title":"Ann R Coll Surg Eng"},{"key":"2024092718173481000_bib3","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1002\/bjs.1800700704","article-title":"Bile \u2018acid\u2019 and lysolecithin concentrations in the stomach of patients with gastric ulcer before operation and after treatment by highly selective vagotomy. 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