{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:24Z","timestamp":1786977384980,"version":"build-2736575974"},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"6","license":[{"start":{"date-parts":[[1986,6,1]],"date-time":"1986-06-01T00:00:00Z","timestamp":517968000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,6,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Between 1982 and 1984, fine needle aspiration biopsy cytology (ABC) was performed in 1100 patients (aged 14\u201380, 993 women), with nodular goitre, who had either a solitary cold nodule or dominant hypofunctioning nodule(s) within a multinodular or diffusely enlarged gland. Surgery was performed in 213 patients based on clinical and cytological criteria, and the histology of the surgical specimens was correlated with the cytological findings. ABC specimens were sufficient for cytological diagnosis in 190 patients and were classified as malignant (positive), suspicious or benign. In 37 patients who had a final histological diagnosis of malignancy, cytology was positive or suspicious in 33 and benign in 4. In the remaining 153 patients with benign histology there were 7 positive or suspicious aspirates, and 146 benign. The 37 malignancies included papillary carcinomas in 26 patients (24 positive or suspicious and 2 benign on cytology), H\u00fcrthle-cell tumours in 6 (6 positive), follicular carcinoma in 1 (negative), anaplastic carcinoma in 1 (suspicious), medullary carcinoma in 2 (1 positive, 1 negative), and lymphoma in 1 (positive). Our results indicate that the overall sensitivity rate of the ABC method for cancer was 89\u00b72 per cent, the diagnostic specificity 95\u00b74 per cent, the false-positive rate 17\u00b75 per cent and the false negative rate 2\u00b76 per cent. The overall accuracy of the method was 94\u00b72 per cent. It is concluded that papillary and H\u00fcrthle-cell carcinomas can be diagnosed accurately with ABC but we recommend that the method be used in conjunction with clinical information and other conventional diagnostic procedures.<\/jats:p>","DOI":"10.1002\/bjs.1800730615","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T02:25:28Z","timestamp":1172888728000},"page":"461-464","source":"Crossref","is-referenced-by-count":32,"title":["Fine needle aspiration biopsy cytology in the diagnosis of thyroid cancer: Comparative study of 213 operated patients"],"prefix":"10.1093","volume":"73","author":[{"given":"P","family":"Harsoulis","sequence":"first","affiliation":[{"name":"Endocrine Unit, Aghia Sophia Hospital , Thessaloniki,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Leontsinit","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, Aghia Sophia Hospital , Thessaloniki,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Economout","sequence":"additional","affiliation":[{"name":"Laboratory of Pathology, Aghia Sophia Hospital , Thessaloniki,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T","family":"Gerasimidis","sequence":"additional","affiliation":[{"name":"2nd Propedeutic Surgical Clinic of Aristotelian University of Thessaloniki, Aghia Sophia Hospital , Thessaloniki,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C","family":"Smbarounis","sequence":"additional","affiliation":[{"name":"2nd Propedeutic Surgical Clinic of Aristotelian University of Thessaloniki, Aghia Sophia Hospital , Thessaloniki,","place":["Greece"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1986,6,1]]},"reference":[{"key":"2024092718194038600_bib1","doi-asserted-by":"crossref","first-page":"270","DOI":"10.7326\/0003-4819-87-3-270_1","article-title":"Combined ultrasound and needle aspiration cytology in the assessment and management of hypofunctioning thyroid nodule","volume":"87","author":"Walfish","year":"1977","journal-title":"Ann Int Med"},{"key":"2024092718194038600_bib2","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1097\/00003072-197711000-00014","article-title":"Thin needle aspiration biopsy and cytological examination of hypofunctional \u2018cold\u2019 thyroid nodules in routine clinical work","volume":"11","author":"Galvan","year":"1977","journal-title":"Clin Nucl Med"},{"key":"2024092718194038600_bib3","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1177\/000348947808700213","article-title":"Fine needle biopsy of the thyroid gland. A cytohistological comparison in cases of goiter","volume":"87","author":"Schnuerer","year":"1978","journal-title":"Ann Otol Rhinol Laryngol"},{"key":"2024092718194038600_bib4","first-page":"194","article-title":"Needle aspiration of 310 thyroid lesions","volume":"23","author":"Friedman","year":"1978","journal-title":"Acta Cytologica"},{"key":"2024092718194038600_bib5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/BF01657837","article-title":"Aspiration biopsy cytology in diagnosis of thyroid cancer","volume":"5","author":"L\u00f6whagen","year":"1981","journal-title":"World J Surg"},{"key":"2024092718194038600_bib6","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/BF01561505","article-title":"Needle aspiration and needle biopsy of the thyroid","volume":"2","author":"Esselstyn","year":"1978","journal-title":"World J Surg"},{"key":"2024092718194038600_bib7","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1016\/0002-9343(82)90731-8","article-title":"Fine needle aspiration biopsy of thyroid nodules. Impact on thyroid practice and cost of care","volume":"73","author":"Hamberger","year":"1982","journal-title":"Am J Med"},{"key":"2024092718194038600_bib8","first-page":"611","article-title":"Fine needle aspiration versus drill-needle biopsy of of thyroid nodules: A controlled clinical trial","volume":"91","author":"Boey","year":"1982","journal-title":"Surgery"},{"key":"2024092718194038600_bib9","first-page":"1289","article-title":"Subcommittee for the study of endemic goitre and iodine deficiency of the European thyroid association. Goitre and iodine defiency in Europe","volume":"i","year":"1985","journal-title":"Lancet"},{"key":"2024092718194038600_bib10","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1002\/bjs.1800590711","article-title":"The single thyroid nodule","volume":"59","author":"Psarras","year":"1972","journal-title":"Br J Surg"},{"key":"2024092718194038600_bib11","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1002\/bjs.1800611204","article-title":"The single thyroid nodule and carcinoma","volume":"61","author":"Messaris","year":"1974","journal-title":"Br J Surg"},{"key":"2024092718194038600_bib12","first-page":"50","article-title":"Fine needle aspiration biopsy cytology in the diagnosis of thyroid cancer","volume":"265","author":"Harsoulis","year":"1984","journal-title":"Acta Endocrinol"},{"key":"2024092718194038600_bib13","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/00000658-198003000-00015","article-title":"Diagnosis of carotid artery stenosis. Comparison of oculoplethysmography and Doppler supraorbital examination","volume":"191","author":"Malone","year":"1980","journal-title":"Ann Surg"},{"key":"2024092718194038600_bib14","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1210\/edrv-5-2-185","article-title":"The cold thyroid nodules: an analysis of diagnostic and therapeutic options","volume":"5","author":"Molitch","year":"1984","journal-title":"Endocr Reviews"},{"key":"2024092718194038600_bib15","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/BF01654913","article-title":"A prospective controlled study of fine-needle aspiration and Tru-cut needle biopsy of dominant thyroid nodules","volume":"8","author":"Boey","year":"1984","journal-title":"World J Surg"},{"key":"2024092718194038600_bib16","doi-asserted-by":"crossref","first-page":"265","DOI":"10.7326\/0003-4819-87-3-265","article-title":"Fine needle aspiration cytology in the preoperative diagnosis of thyroid nodules","volume":"87","author":"Gershengorn","year":"1977","journal-title":"Ann Int Med"},{"key":"2024092718194038600_bib17","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0002-9610(83)90262-3","article-title":"Thyroid nodules indeterminate by needle biopsy","volume":"146","author":"Block","year":"1983","journal-title":"Am J Surg"},{"key":"2024092718194038600_bib18","first-page":"747","article-title":"Re-evaluation of needle aspiration cytology in the detection of thyroid cancer","volume":"90","author":"Rosen","year":"1981","journal-title":"Surgery"},{"key":"2024092718194038600_bib19","first-page":"835","article-title":"Comparison of fine-needle and coarse-needle biopsies in evaluating thyroid nodules","volume":"92","author":"LoGerfo","year":"1982","journal-title":"Surgery"},{"key":"2024092718194038600_bib20","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1007\/BF01654911","article-title":"Evaluation of various types of needle biopsies of the thyroid","volume":"8","author":"Esselstyn","year":"1984","journal-title":"World J Surg"},{"key":"2024092718194038600_bib21","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1001\/jama.1979.03290310021006","article-title":"Diagnosis of thyroid nodules: use of fine-needle aspiration and needle biopsy","volume":"241","author":"Miller","year":"1979","journal-title":"J Am Med Assoc"},{"key":"2024092718194038600_bib22","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF01657831","article-title":"Primary lymphoma of the thyroid: A review of the Mayo clinic experience through 1978","volume":"5","author":"Devine","year":"1981","journal-title":"World J Surg"},{"key":"2024092718194038600_bib23","first-page":"365","article-title":"Needle biopsy of the thyroid","volume":"143","author":"Wang","year":"1976","journal-title":"Surg Gynecol Obstet"},{"key":"2024092718194038600_bib24","first-page":"241","article-title":"Aspiration biopsy of thyroid nodules","volume":"136","author":"Crile","year":"1973","journal-title":"Surg Gynecol Obstet"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800730615","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/73\/6\/461\/59381881\/bjs1800730615.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/73\/6\/461\/59381881\/bjs1800730615.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T14:19:55Z","timestamp":1727446795000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/73\/6\/461\/6182782"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,6,1]]},"references-count":24,"journal-issue":{"issue":"6","published-online":{"date-parts":[[1986,6,1]]},"published-print":{"date-parts":[[1986,6,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800730615","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"value":"0007-1323","type":"print"},{"value":"1365-2168","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1986,6]]},"published":{"date-parts":[[1986,6,1]]}}}