{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,24]],"date-time":"2025-10-24T07:28:06Z","timestamp":1761290886007},"reference-count":15,"publisher":"Oxford University Press (OUP)","issue":"8","license":[{"start":{"date-parts":[[1986,8,1]],"date-time":"1986-08-01T00:00:00Z","timestamp":523238400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>For many years, the classical Whipple procedure has been the standard operative treatment for resectable periampullary cancer. Recently, the pylorus preservation operation has also been applied to periampullary tumours. This newer procedure has potential advantages in terms of ease of performance and postoperative physiology, but has yet to be proved as an adequate cancer operation. We, therefore, undertook the present retrospective analysis to compare the outcome following the pylorus preservation operation (n = 13) with that of the classical Whipple resection (n = 13) in 26 patients with histologically proved adenocarcinoma of the head of the pancreas. The two groups of patients were comparable for age, sex, pre-operative laboratory data, and resected margins free from tumour. More patients undergoing the classical Whipple resection had Stage I disease (10 versus 4, P &amp;lt; 0.05). However, this difference would not be significant if the two patients in the pylorus preservation group with carcinomas in situ were considered to have stage I disease. Mean tumour diameter in the pylorus preservation patient group (3\u00b72\u00b10\u00b76 cm) was smaller (P &amp;lt;0\u00b705) than in the classical Whipple group (4\u00b71\u00b11\u00b70 cm) but more patients in the pylorus preservation group also had metastases to the regional lymph nodes (54 versus 23 per cent). Overall operative morbidity (31 per cent) and mortality (4 per cent) was acceptable and did not differ between the two groups. Five year actuarial survival for pylorus preservation (25 per cent) was comparable to that observed for the Whipple procedure in this and other series.<\/jats:p>","DOI":"10.1002\/bjs.1800730824","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T07:05:08Z","timestamp":1172905508000},"page":"647-650","source":"Crossref","is-referenced-by-count":78,"title":["Pancreatoduodenectomy with pylorus preservation for adenocarcinoma of the head of the pancreas"],"prefix":"10.1093","volume":"73","author":[{"given":"P A","family":"Grace","sequence":"first","affiliation":[{"name":"Department of Surgery, UCLA School of Medicine , Los Angeles, California,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H A","family":"Pitt","sequence":"additional","affiliation":[{"name":"Department of Surgery, UCLA School of Medicine , Los Angeles, California,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W P","family":"Longmire","sequence":"additional","affiliation":[{"name":"Department of Surgery, UCLA School of Medicine , Los Angeles, California,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1986,8,1]]},"reference":[{"key":"2024092719354168100_bib1","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1097\/00000658-194111440-00008","article-title":"The rationale of radical surgery for cancer of the pancreas and ampullary region","volume":"114","author":"Whipple","year":"1941","journal-title":"Ann Surg"},{"key":"2024092719354168100_bib2","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1002\/1097-0142(19810315)47:6+<1706::AID-CNCR2820471441>3.0.CO;2-7","article-title":"The Whipple procedure and other standard operative approaches to pancreatic cancer","volume":"47","author":"Longmire","year":"1981","journal-title":"Cancer"},{"key":"2024092719354168100_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000658-197907000-00001","article-title":"Anastomotic ulceration following subtotal and total pancreatectomy","volume":"190","author":"Grant","year":"1979","journal-title":"Ann Surg"},{"key":"2024092719354168100_bib4","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1097\/00000658-198006000-00005","article-title":"The role of vagotomy in pancreaticoduodenectomy","volume":"191","author":"Scott","year":"1980","journal-title":"Ann Surg"},{"key":"2024092719354168100_bib5","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1097\/00000658-198009000-00005","article-title":"Preservation of the pylorus in pancreaticoduodenectomy","volume":"192","author":"Traverso","year":"1980","journal-title":"Ann Surg"},{"key":"2024092719354168100_bib6","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/0002-9610(83)90182-4","article-title":"Pyloric and gastric preservation with pancreatoduodenectomy","volume":"145","author":"Newman","year":"1983","journal-title":"Am J Surg"},{"key":"2024092719354168100_bib7","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1056\/NEJM197909063011006","article-title":"Atypical papillary hyperplasia of the pancreatic duct mimicking obstructive pancreatic carcinoma","volume":"310","author":"Ferrari","year":"1979","journal-title":"N Engl J Med"},{"key":"2024092719354168100_bib8","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1097\/00000658-198404000-00008","article-title":"Regional pancreatectomy for cancer of the pancreas, ampulla, and other related sites","volume":"199","author":"Fortner","year":"1984","journal-title":"Ann Surg"},{"key":"2024092719354168100_bib9","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1080\/01621459.1958.10501452","article-title":"Nonparametric estimation from incomplete observations","volume":"53","author":"Kaplan","year":"1958","journal-title":"J Am Statist Assoc"},{"key":"2024092719354168100_bib10","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1038\/bjc.1976.220","article-title":"Design and analysis of randomized clinical trials requiring prolonged observation of each patient","volume":"34","author":"Peto","year":"1976","journal-title":"Br J Cancer"},{"key":"2024092719354168100_bib11","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1097\/00000658-198404000-00010","article-title":"Pancreaticoduodenal resection","volume":"199","author":"Lerut","year":"1984","journal-title":"Ann Surg"},{"key":"2024092719354168100_bib12","first-page":"1","article-title":"Delayed gastric emptying after pylorus preserving pancreaticoduodenectomy","volume":"160","author":"Warshaw","year":"1985","journal-title":"Surg Gynecol Obstet"},{"key":"2024092719354168100_bib13","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/0002-9610(86)90024-3","article-title":"Improved morbidity and mortality following pancreatoduodenectomy","volume":"151","author":"Grace","year":"1986","journal-title":"Am J Surg"},{"key":"2024092719354168100_bib14","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/00000658-198203000-00006","article-title":"Surgical experience with pancreatic and periampullary cancer","volume":"195","author":"Hertner","year":"1982","journal-title":"Ann Surg"},{"key":"2024092719354168100_bib15","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1001\/archsurg.1973.01350180047015","article-title":"Pancreaticoduodenal resection: twenty years experience","volume":"106","author":"Aston","year":"1973","journal-title":"Arch Surg"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800730824","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/73\/8\/647\/59382596\/bjs1800730824.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/73\/8\/647\/59382596\/bjs1800730824.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T19:36:02Z","timestamp":1727465762000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/73\/8\/647\/6182179"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,8,1]]},"references-count":15,"journal-issue":{"issue":"8","published-online":{"date-parts":[[1986,8,1]]},"published-print":{"date-parts":[[1986,8,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800730824","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"type":"print","value":"0007-1323"},{"type":"electronic","value":"1365-2168"}],"subject":[],"published-other":{"date-parts":[[1986,8]]},"published":{"date-parts":[[1986,8,1]]}}}