{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T12:39:05Z","timestamp":1760099945914},"reference-count":22,"publisher":"Oxford University Press (OUP)","issue":"9","license":[{"start":{"date-parts":[[1986,9,1]],"date-time":"1986-09-01T00:00:00Z","timestamp":525916800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,9,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In a prospective, double-blind investigation of the prophylaxis of deep vein thrombosis (DVT) in patients undergoing elective major abdominal surgery, 269 patients were randomized into two groups. One hundred and thirty-two patients received a fixed combination of heparin sodium 5000 units plus dihydroergotamine mesylate 0.5 mg (H\/DHE) twice a day and 137 patients received a fixed combination of low molecular weight heparin 1500 units plus dihydroergotamine mesylate 0.5 mg (LMWH\/DHE) once a day as well as one injection of placebo per day. Treatment was initiated 2 h pre-operatively in both groups and continued for 7\u201310 days. The frequency of DVT determined by the 125I-labelled fibrinogen uptake test and phlebography was 10.3 per cent in patients receiving H\/DHE and 10.4 per cent in those receiving LMWH\/DHE. DVT of the femoral vein was detected in four patients of the H\/DHE group and in none of the LMWH\/DHE group. Intra- and postoperative blood loss did not differ significantly between both groups. Also no difference in the development of wound haematoma and injection site haematoma was found. While intra-operative volume substitution was comparable in both groups, significantly more patients under H\/DHE prophylaxis received volume substitution during the postoperative phase. These results show that once-daily prophylaxis with the combination of low molecular weight heparin and dihydroergotamine is equally as effective and as safe as the twice-daily regimen using a combination of unfractionated heparin and dihydroergotamine in patients undergoing elective, major abdominal surgery. The advantages of the once-daily regimen of LMWH\/DHE include greater patient acceptance, less nursing time and greater cost effectiveness, provided the new combination can be sold at a cost which maintains this advantage.<\/jats:p>","DOI":"10.1002\/bjs.1800730906","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T07:57:32Z","timestamp":1172908652000},"page":"697-700","source":"Crossref","is-referenced-by-count":47,"title":["Low molecular weight heparin plus dihydroergotamine for prophylaxis of postoperative deep vein thrombosis"],"prefix":"10.1093","volume":"73","author":[{"given":"A A","family":"Sasahara","sequence":"first","affiliation":[{"name":"Research and Medical Services, Brockton\/West Roxbury Veterans Administration Medical Center, the Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K","family":"Koppenhagen","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine, Universit\u00e4klinikum Steglitz , West Berlin,","place":["FRG"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R","family":"H\u00e4ring","sequence":"additional","affiliation":[{"name":"Department of Surgery, Universit\u00e4klinikum Steglitz , West Berlin,","place":["FRG"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Welzel","sequence":"additional","affiliation":[{"name":"Sandoz AG, Klinische Forschung , Nuremberg,","place":["FRG"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H","family":"Wolf","sequence":"additional","affiliation":[{"name":"Research and Medical Services, Brockton\/West Roxbury Veterans Administration Medical Center, the Departments of Medicine, Brigham and Women's Hospital and Harvard Medical School , Boston, Massachusetts,","place":["USA"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1986,9,1]]},"reference":[{"key":"2024092718360355000_bib1","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/S0008-6215(00)87070-6","article-title":"The relationship of molecular weight, and sulfate content and distribution to anticoagulant activity of heparin preparations","volume":"37","author":"Cifonelli","year":"1974","journal-title":"Carbohydr Res"},{"key":"2024092718360355000_bib2","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/S0008-6215(00)84041-0","article-title":"The molecular range of mucosal heparin preparations","volume":"51","author":"Johnson","year":"1976","journal-title":"Carbohydr Res"},{"key":"2024092718360355000_bib3","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1600-0609.1980.tb02511.x","article-title":"Anticoagulant properties of heparin and heparin fractions","volume":"36","author":"Holmer","year":"1980","journal-title":"Scand J Haemat"},{"key":"2024092718360355000_bib4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/0049-3848(78)90082-8","article-title":"Anticoagulant activities of lung and mucous heparin","volume":"12","author":"Barrowcliffe","year":"1978","journal-title":"Thromb Res"},{"key":"2024092718360355000_bib5","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1111\/j.1365-2141.1979.tb05894.x","article-title":"Anticoagulant activities of high and low molecular weight heparin fractions","volume":"41","author":"Barrowcliffe","year":"1979","journal-title":"Br J Haemat"},{"key":"2024092718360355000_bib6","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/0049-3848(76)90105-5","article-title":"Anticoagulant properties of heparin fractionated by affinity chromatography on matrix bound antithrombin III and by gel filtration","volume":"9","author":"Andersson","year":"1976","journal-title":"Thromb Res"},{"key":"2024092718360355000_bib7","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/0006-291X(76)90558-1","article-title":"The separation of active and inactive form of heparin","volume":"69","author":"Lam","year":"1976","journal-title":"Biochem Biophys Res Commun"},{"key":"2024092718360355000_bib8","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1055\/s-0038-1648001","article-title":"Four heparin preparations. 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