{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T03:11:12Z","timestamp":1762917072672},"reference-count":11,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[1986,10,1]],"date-time":"1986-10-01T00:00:00Z","timestamp":528508800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This study investigated the role of long-term reflux of bile and\/or pancreaticoduodenal secretions in the genesis of gastric carcinoma in the rat. Adenocarcinoma, dysplasia and adenocystic proliferation were found only in those animals with reflux of pancreaticoduodenal secretions alone or in combination with bile. No such changes were found in control animals with no reflux or animals with bile reflux alone. The differences in incidence of adenocarcinoma were significant. The presence of adenocarcinoma was not related to the pH of the intragastric contents or to the bacterial flora. This suggests that duodenogastric reflux is implicated in gastric carcinogenesis in the rat and that pancreaticoduodenal secretions rather than bile are responsible.<\/jats:p>","DOI":"10.1002\/bjs.1800731014","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T05:58:31Z","timestamp":1172901511000},"page":"801-803","source":"Crossref","is-referenced-by-count":58,"title":["Duodenogastric reflux in rat gastric carcinoma"],"prefix":"10.1093","volume":"73","author":[{"given":"R C","family":"Mason","sequence":"first","affiliation":[{"name":"Department of Surgery, United Medical and Dental Schools, Guy's and St. Thomas', Guy's Hospital , St. Thomas' Street, London SE1,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1986,10,1]]},"reference":[{"key":"2024100215054121600_bib1","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/0306-9877(79)90112-9","article-title":"Gastric caricnoma promoted by alkaline reflux gastritis with special reference to bile and other surfactants as promotors of postoperative gastric cancer","volume":"5","author":"Domellof","year":"1979","journal-title":"Med Hypothesis"},{"key":"2024100215054121600_bib2","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/bjc.1971.66","article-title":"Bacteria and the N-nitrosation of secondary amines","volume":"25","author":"Hawksworth","year":"1971","journal-title":"Br J Cancer"},{"key":"2024100215054121600_bib3","first-page":"287","volume-title":"Precursors of Gastric Cancer","author":"Gad","year":"1984"},{"key":"2024100215054121600_bib4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1002\/bjs.1800720803","article-title":"Cancer following gastric surgery","volume":"72","author":"Clark","year":"1985","journal-title":"Br J Surg"},{"key":"2024100215054121600_bib5","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1007\/BF01655015","article-title":"Operation sequel gastric carcinoma of the stomach. Experimental studies of surgical techniques with or without resection","volume":"5","author":"Langhans","year":"1981","journal-title":"World J Surg"},{"key":"2024100215054121600_bib6","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/0009-8981(70)90078-1","article-title":"Quantitative determination of the major 3a hydroxybile acids in biological material after thin layer chromatographic separation","volume":"28","author":"Brusgaard","year":"1970","journal-title":"Clin Chim Acta"},{"key":"2024100215054121600_bib7","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/0002-9610(80)90024-0","article-title":"Microflora and deconjugation of bile acids in alkalin reflux after partial gastrectomy","volume":"140","author":"Domellof","year":"1980","journal-title":"Am J Surg"},{"key":"2024100215054121600_bib8","first-page":"193","volume-title":"Human intestinal flora","author":"Draser","year":"1974"},{"key":"2024100215054121600_bib9","first-page":"399","article-title":"Altered patterns of mucin secretion precancerous lesions induced in the glandular part of the rat stomach by the carcinogen N-methyl-N-nitro-N-nitroguanidine","volume":"3","author":"Tsiftsis","year":"1980","journal-title":"Invest Cell Pathol"},{"key":"2024100215054121600_bib10","first-page":"276","volume-title":"Gastroenterology 1 Foregut","author":"Siurala","year":"1981"},{"key":"2024100215054121600_bib11","first-page":"87","volume-title":"Gastric Carcinoma","author":"Filipe","year":"1986"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800731014","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/73\/10\/801\/59495281\/bjs1800731014.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/73\/10\/801\/59495281\/bjs1800731014.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,2]],"date-time":"2024-10-02T15:34:48Z","timestamp":1727883288000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/73\/10\/801\/6182345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1986,10,1]]},"references-count":11,"journal-issue":{"issue":"10","published-online":{"date-parts":[[1986,10,1]]},"published-print":{"date-parts":[[1986,10,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800731014","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"type":"print","value":"0007-1323"},{"type":"electronic","value":"1365-2168"}],"subject":[],"published-other":{"date-parts":[[1986,10]]},"published":{"date-parts":[[1986,10,1]]}}}