{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:16:47Z","timestamp":1764688607427},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"12","license":[{"start":{"date-parts":[[1986,12,1]],"date-time":"1986-12-01T00:00:00Z","timestamp":533779200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1986,12,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Oral supplements of calcium reduce the mitogenic effects of fatty acids and bile acids on large bowel mucosa. The cytokinetic effects of intraluminal calcium were tested in normal and adapting colonic epithelium. Male Sprague\u2013Dawley rats (n = 60) weighing 356\u00b77 \u00b1 24\u00b79 g were submitted to either an 80 per cent jejuno-ileal resection or simple transection and resuture of the jejunum. Within each group, half the animals had 24 g\/l calcium lactate added to the drinking water. Seven weeks postoperatively crypt cell production rate (CCPR) was determined in the lower descending colon. Among controls with transection CCPR was 4\u00b749 cells crypt\u22121 h\u22121; calcium supplements reduced this figure by 26 per cent (P &amp;lt; 0\u00b705). As expected jejuno-ileal resection increased CCPR (by 51\u201361 per cent), but again calcium reduced this response by 31 per cent (P &amp;lt; 0\u00b702). Increased dietary levels of calcium thus inhibit colonic cell turnover and blunt the adaptive response to massive enterectomy, conceivably by binding tropic factors such as bile acids.<\/jats:p>","DOI":"10.1002\/bjs.1800731229","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T06:33:45Z","timestamp":1172903625000},"page":"1018-1021","source":"Crossref","is-referenced-by-count":22,"title":["Increased dietary calcium and small bowel resection have opposite effects on colonic cell turnover"],"prefix":"10.1093","volume":"73","author":[{"given":"G V N","family":"Appleton","sequence":"first","affiliation":[{"name":"University Department of Surgery, Bristol Royal Infirmary , Bristol,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J B","family":"Bristol","sequence":"additional","affiliation":[{"name":"University Department of Surgery, Bristol Royal Infirmary , Bristol,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R C N","family":"Williamson","sequence":"additional","affiliation":[{"name":"University Department of Surgery, Bristol Royal Infirmary , Bristol,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1986,12,1]]},"reference":[{"key":"2024100215054548900_bib1","first-page":"57","article-title":"The relationship between intestinal hyperplasia and carcinogenesis","volume":"19","author":"Williamson","year":"1984","journal-title":"Scand J Gastroenterol"},{"key":"2024100215054548900_bib2","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1136\/gut.26.10.999","article-title":"Crypt cell production rate in ulcerative proctocolitis: differential increments in remission and 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