{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T03:20:32Z","timestamp":1761708032819},"reference-count":16,"publisher":"Oxford University Press (OUP)","issue":"7","license":[{"start":{"date-parts":[[1987,7,1]],"date-time":"1987-07-01T00:00:00Z","timestamp":552096000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Physiological abnormalities in the anorectum of 34 patients with pruritus ani, and 20 age and sex matched controls were assessed. A saline infusion (1500 ml) test showed that leakage started after infusion of 600 ml in patients with pruritus ani compared with 1300 ml in controls (median values: P&amp;lt;0\u00b7001). There was an inverse relationship between the severity of the symptoms of pruritus ani and the volume of first leakage on the saline infusion test P&amp;lt;0\u00b702. Studies to assess anal sphincter function, rectal sensation to balloon distension, rectal compliance, and perineal descent did not show any significant differences between pruritic patients and controls. However, pruritic patients without co-existing anal pathology had a significantly greater fall of anal pressure when a rectal balloon was inflated (57 per cent) when compared with controls (40 per cent) P&amp;lt;0\u00b705.<\/jats:p>","DOI":"10.1002\/bjs.1800740710","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T09:58:09Z","timestamp":1172915889000},"page":"576-579","source":"Crossref","is-referenced-by-count":42,"title":["Physiological study of pruritus ani"],"prefix":"10.1093","volume":"74","author":[{"given":"A","family":"Allan","sequence":"first","affiliation":[{"name":"Department of Surgery, General Hospital , Steelhouse Lane, Birmingham B4 6NH,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N S","family":"Ambrose","sequence":"additional","affiliation":[{"name":"Department of Surgery, General Hospital , Steelhouse Lane, Birmingham B4 6NH,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S","family":"Silverman","sequence":"additional","affiliation":[{"name":"Department of Surgery, General Hospital , Steelhouse Lane, Birmingham B4 6NH,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M R B","family":"Keighley","sequence":"additional","affiliation":[{"name":"Department of Surgery, General Hospital , Steelhouse Lane, Birmingham B4 6NH,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1987,7,1]]},"reference":[{"key":"2024092719420338100_bib1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0300-5089(21)00259-5","article-title":"Dermatological aspects of anorectal disease","volume":"4","author":"Alexander","year":"1975","journal-title":"Clinics in Gastroenterology"},{"key":"2024092719420338100_bib2","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1136\/bmj.287.6386.159","article-title":"Pruritus ani","volume":"287","author":"Alexan der Williams","year":"1983","journal-title":"Br Med J"},{"key":"2024092719420338100_bib3","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/S0016-5085(83)80236-4","article-title":"Use of anorectal manometry during rectal infusion of saline to investigate sphincter function in incontinent patients","volume":"85","author":"Reed","year":"1983","journal-title":"Gastroenterology"},{"key":"2024092719420338100_bib4","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/bjs.1800690813","article-title":"The pelvic floor musculature in the descending perineum syndrome","volume":"69","author":"Henry","year":"1982","journal-title":"Br J Surg"},{"key":"2024092719420338100_bib5","first-page":"306","article-title":"Outpatient measurement of perineal descent","volume":"67","author":"Ambrose","year":"1985","journal-title":"Ann R Coll Surg Engl"},{"key":"2024092719420338100_bib6","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1002\/bjs.1800710109","article-title":"The balloon proctogram","volume":"71","author":"Preston","year":"1984","journal-title":"Br J Surg"},{"key":"2024092719420338100_bib7","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/S0016-5085(79)80175-4","article-title":"Clinical study of patients with faecal incontinence and diarrhoea","volume":"76","author":"Read","year":"1979","journal-title":"Gastroenterology"},{"key":"2024092719420338100_bib8","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1136\/gut.22.2.126","article-title":"Manometric evaluation of rectal prolapse for faecal incontinence","volume":"22","author":"Matheson","year":"1981","journal-title":"Gut"},{"key":"2024092719420338100_bib9","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/S0016-5085(84)80118-3","article-title":"Longitudinal and radial variations of pressure in the human anal sphincter","volume":"86","author":"Taylor","year":"1984","journal-title":"Gastroenterology"},{"key":"2024092719420338100_bib10","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1007\/BF02553616","article-title":"Prospective studies in the aetiology and treatment of pruritus ani","volume":"25","author":"Smith","year":"1982","journal-title":"Dis Colon Rectum"},{"key":"2024092719420338100_bib11","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1002\/bjs.1800680409","article-title":"The importance of pain, pruritus ani and soiling as symptoms of haemorrhoids and their response to haemorrhoidectomy or rubber band ligation","volume":"68","author":"Murrie","year":"1981","journal-title":"Br J Surg"},{"key":"2024092719420338100_bib12","doi-asserted-by":"crossref","first-page":"1549","DOI":"10.1136\/bmj.2.6204.1549","article-title":"Pruritus ani: Is anal sphincter dysfunction important in aetiologyarticle-title","volume":"2","author":"Eyers","year":"1979","journal-title":"Br Med J"},{"key":"2024092719420338100_bib13","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/0002-9610(77)90445-7","article-title":"Anal pressure in haemorrhoids and anal fissure","volume":"134","author":"Arabi","year":"1977","journal-title":"Am J Surg"},{"key":"2024092719420338100_bib14","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1136\/gut.18.8.651","article-title":"The internal sphincter and the nature of haemorrhoids","volume":"18","author":"Hancock","year":"1977","journal-title":"Gut"},{"key":"2024092719420338100_bib15","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1007\/BF02586913","article-title":"A method for determining individual contributions of voluntary and involuntary anal sphincters to resting tone","volume":"22","author":"Schweiger","year":"1979","journal-title":"Dis Colon Rectum"},{"key":"2024092719420338100_bib16","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1136\/gut.22.1.45","article-title":"Hypertrophy of the external anal sphincter in haemorrhoids. A histometric study","volume":"22","author":"Terramoto","year":"1983","journal-title":"Gut"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800740710","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/74\/7\/576\/59383537\/bjs1800740710.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/74\/7\/576\/59383537\/bjs1800740710.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T19:43:32Z","timestamp":1727466212000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/74\/7\/576\/6183538"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,7,1]]},"references-count":16,"journal-issue":{"issue":"7","published-online":{"date-parts":[[1987,7,1]]},"published-print":{"date-parts":[[1987,7,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800740710","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"type":"print","value":"0007-1323"},{"type":"electronic","value":"1365-2168"}],"subject":[],"published-other":{"date-parts":[[1987,7]]},"published":{"date-parts":[[1987,7,1]]}}}