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No significant difference in lower oesophageal sphincter pressure was demonstrated between the two groups. The Barrett's patients demonstrated significantly greater acid exposure in the distal oesophagus than oesophagitis patients. Clearance of refluxed acid was poorer in Barrett's patients than oesophagitis patients. Twelve of the Barrett's patients presented with complications of the condition, i.e. ulceration or stricture. No significant difference in acid exposure was demonstrated between Barrett's patients with or without complications. These results suggest that patients with columnar-lined (Barrett's) oesophagus have greater acid exposure than patients with oesophagitis. The development of complications of a Barrett's oesophagus may not be dependent on acid reflux alone.<\/jats:p>","DOI":"10.1002\/bjs.1800740906","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T10:27:40Z","timestamp":1172917660000},"page":"774-776","source":"Crossref","is-referenced-by-count":87,"title":["Barrett's oesophagus: pH profile"],"prefix":"10.1093","volume":"74","author":[{"given":"P","family":"Gillen","sequence":"first","affiliation":[{"name":"Departments of Surgery and Pathology, Trinity College Medical School, St. James's Hospital , Dublin,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Keeling","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Pathology, Trinity College Medical School, St. James's Hospital , Dublin,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P J","family":"Byrne","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Pathology, Trinity College Medical School, St. James's Hospital , Dublin,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T P J","family":"Hennessy","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Pathology, Trinity College Medical School, St. James's Hospital , Dublin,","place":["Ireland"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1987,9,1]]},"reference":[{"key":"2024092719471177000_bib1","first-page":"29","volume-title":"Barrett's Oesophagus: Pathophysiology, Diagnosis and Management","author":"Hamilton","year":"1985"},{"key":"2024092719471177000_bib2","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1016\/S0016-5085(66)80127-0","article-title":"The columnar-lined esophagus (Barrett syndrome): an acquired 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concentrations in the gastric juice of patients with erosive oesophagitis","volume":"26","author":"Collins","year":"1985","journal-title":"Gut"}],"container-title":["Journal of British 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