{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,2]],"date-time":"2025-12-02T15:16:51Z","timestamp":1764688611967},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"10","license":[{"start":{"date-parts":[[1987,10,1]],"date-time":"1987-10-01T00:00:00Z","timestamp":560044800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,10,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In a review of cases of colorectal cancer presenting to St. Mark's Hospital over the 16-year period 1970\u201385, 59 patients were found to have a synchronous carcinoma (3\u00b74 per cent). Although 82 per cent of these synchronous tumours were distal to the splenic flexure (and hence within reach of a 60 cm flexible sigmoidoscope) only 42 per cent were detected pre-operatively: the remaining tumours were noted at surgery (24 per cent) or found incidentally on pathological examination of the resected specimen (34 per cent). Histological examination of these synchronous lesions revealed a high proportion with favourable stage (Dukes' A \u2014 75 per cent) and grade (well or moderate differentiation - 90 per cent). Over the same 16-year period, 10 patients presented with an \u2018early\u2019 metachronous lesion (&amp;lt;3 years from initial surgery). Review of these cases noted negative findings on the initial barium studies in four patients and a failure to conduct full examination of the colon at initial presentation in the remaining six. It is concluded that full examination of the colon in all patients presenting with primary colorectal cancer is mandatory and that, in the light of this experience and recent reports in the literature, this should be by pre- or peroperative colonoscopy.<\/jats:p>","DOI":"10.1002\/bjs.1800741021","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T08:41:50Z","timestamp":1172911310000},"page":"945-947","source":"Crossref","is-referenced-by-count":66,"title":["Synchronous and \u2018early\u2019 metachronous carcinomas of the colon and rectum"],"prefix":"10.1093","volume":"74","author":[{"given":"P J","family":"Finan","sequence":"first","affiliation":[{"name":"St. Mark's Hospital , City Road, London EC1,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean K","family":"Ritchie","sequence":"additional","affiliation":[{"name":"St. Mark's Hospital , City Road, London EC1,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P R","family":"Hawley","sequence":"additional","affiliation":[{"name":"St. Mark's Hospital , City Road, London EC1,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1987,10,1]]},"reference":[{"key":"2024092719354570200_bib1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1007\/BF02587230","article-title":"Clinical experiences at St. Mark's Hospital with multiple synchronous cancers of the colon and rectum","volume":"18","author":"Heald","year":"1975","journal-title":"Dis Colon Rectum"},{"key":"2024092719354570200_bib2","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/bjs.1800590105","article-title":"The lesion of the second cancer of the large bowel","volume":"59","author":"Heald","year":"1972","journal-title":"Br J Surg"},{"key":"2024092719354570200_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/BF02587659","article-title":"Multiple adeno-carcinomas of the colon and rectum","volume":"15","author":"Travieso","year":"1972","journal-title":"Dis Colon Rectum"},{"key":"2024092719354570200_bib4","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1002\/1097-0142(197406)33:6<1630::AID-CNCR2820330624>3.0.CO;2-0","article-title":"Multiple carcinomas of the colon and rectum","volume":"33","author":"Ekelund","year":"1974","journal-title":"Cancer"},{"key":"2024092719354570200_bib5","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1007\/BF02586540","article-title":"Synchronous primary adenocarcinomas of the colon and rectum","volume":"21","author":"Lasser","year":"1978","journal-title":"Dis Colon Rectum"},{"key":"2024092719354570200_bib6","doi-asserted-by":"crossref","first-page":"1870","DOI":"10.1002\/1097-0142(19841101)54:9<1870::AID-CNCR2820540917>3.0.CO;2-5","article-title":"Synchronous and metachronous malignancies of the colon and rectum in Japan with special reference to a co-existing early cancer","volume":"54","author":"Kaibara","year":"1984","journal-title":"Cancer"},{"key":"2024092719354570200_bib7","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1002\/1097-0142(19860201)57:3<445::AID-CNCR2820570307>3.0.CO;2-D","article-title":"The significance of synchronous carcinoma and polyps in the colon and rectum","volume":"57","author":"Chu","year":"1986","journal-title":"Cancer"},{"key":"2024092719354570200_bib8","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1002\/bjs.1800711210","article-title":"Incidence of synchronous and metachronous colorectal carcinoma","volume":"71","author":"Cunliffe","year":"1984","journal-title":"Br J Surg"},{"key":"2024092719354570200_bib9","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/BF02564161","article-title":"Colonoscopy: its role in cancer of the colon and rectum","volume":"25","author":"Reilly","year":"1982","journal-title":"Dis Colon Rectum"},{"key":"2024092719354570200_bib10","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1097\/00000658-198602000-00002","article-title":"A comparison of multiple synchronous colorectal cancer in ulcerative colitis, familial polyposis and de novo cancer","volume":"203","author":"Greenstein","year":"1986","journal-title":"Ann Surg"},{"key":"2024092719354570200_bib11","doi-asserted-by":"crossref","first-page":"2251","DOI":"10.1002\/cncr.2820360944","article-title":"The evolution of cancer of the colon and rectum","volume":"36","author":"Muto","year":"1975","journal-title":"Cancer"},{"key":"2024092719354570200_bib12","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/BF02564169","article-title":"Metachronous colorectal malignancies","volume":"25","author":"Agrez","year":"1982","journal-title":"Dis Colon Rectum"},{"key":"2024092719354570200_bib13","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1007\/BF02555051","article-title":"Metachronous colorectal cancer. 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