{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T20:59:27Z","timestamp":1761512367574},"reference-count":37,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[1987,11,1]],"date-time":"1987-11-01T00:00:00Z","timestamp":562723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"name":"Cancer Research Campaign","award":["SP1256"],"award-info":[{"award-number":["SP1256"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The prognostic significance of the tumour activities of 2 steroid receptors, those for oestrogen (ER) and for progestogen (PgR), has been studied in 372 patients with breast cancer, in whom follow-up was available for 2-6 years (median 41 months). Of 252 patients with operable disease, 75\u00b78 per cent had ER-positive tumours and 46\u00b74 per cent had PgR-positive tumours, though a small additional fraction (6\u00b73 per cent) had an equivocal PgR assay result. For the 236 patients with unequivocal receptor status, the relationships between disease-free interval or overall survival and receptor activity and other factors were evaluated by univariate and multivariate analyses. The latter revealed that only tumour size, node status, menstrual status and ER status related significantly to both disease-free interval and survival, though adjuvant therapy also related to disease-free interval, and tumour grade related to survival. It is concluded that measurements of PgR activity do not add to the prognostic significance of ER status.<\/jats:p>","DOI":"10.1002\/bjs.1800741118","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T08:48:46Z","timestamp":1172911726000},"page":"1009-1013","source":"Crossref","is-referenced-by-count":33,"title":["Prognostic significance of oestrogen and progestogen receptor activities in breast cancer"],"prefix":"10.1093","volume":"74","author":[{"given":"R A","family":"Hawkins","sequence":"first","affiliation":[{"name":"University Department of Clinical Surgery, Royal Infirmary , Edinburgh EH3 9YW,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gillian","family":"White","sequence":"additional","affiliation":[{"name":"Scottish Cancer Trials Office (MRC), Medical School , Edinburgh EH8 9AG,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N J","family":"Bundred","sequence":"additional","affiliation":[{"name":"University Department of Clinical Surgery, Royal Infirmary , Edinburgh EH3 9YW,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M J","family":"Dixon","sequence":"additional","affiliation":[{"name":"University Department of Clinical Surgery, Royal Infirmary , Edinburgh EH3 9YW,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W R","family":"Miller","sequence":"additional","affiliation":[{"name":"University Department of Clinical Surgery, Royal Infirmary , Edinburgh EH3 9YW,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen J","family":"Stewart","sequence":"additional","affiliation":[{"name":"Scottish Cancer Trials Office (MRC), Medical School , Edinburgh EH8 9AG,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A P M","family":"Forrest","sequence":"additional","affiliation":[{"name":"University Department of Clinical Surgery, Royal Infirmary , Edinburgh EH3 9YW,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1987,11,1]]},"reference":[{"key":"2024092719355718700_bib1","first-page":"37","volume-title":"Estrogen Receptors in Human Breast Cancer","author":"McGuire","year":"1975"},{"key":"2024092719355718700_bib2","first-page":"506","article-title":"The surgical implications of estrophile protein estimations in carcinoma of the breast","volume":"80","author":"Walt","year":"1976","journal-title":"Surgery"},{"key":"2024092719355718700_bib3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/BF01855130","article-title":"Prognostic factors in primary breast cancer","volume":"3","author":"Clark","year":"1983","journal-title":"Breast Cancer Res Treat"},{"key":"2024092719355718700_bib4","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0022-4731(81)90275-2","article-title":"Steroid receptors in early breast cancer","volume":"15","author":"Nicholson","year":"1981","journal-title":"J Steroid Biochem"},{"key":"2024092719355718700_bib5","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1136\/bmj.283.6302.1289","article-title":"Oestrogen receptors and survival in early breast cancer","volume":"283","author":"Croton","year":"1981","journal-title":"Br Med J"},{"key":"2024092719355718700_bib6","first-page":"2985","article-title":"Progesterone and estrogen receptors as prognostic variables in breast cancer","volume":"43","author":"Mason","year":"1983","journal-title":"Cancer Res"},{"key":"2024092719355718700_bib7","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1016\/0277-5379(93)90007-R","article-title":"Steroid receptors and prognosis in operable (Stage I and II) Breast Cancer","volume":"19","author":"Stewart","year":"1983","journal-title":"Eur J Cancer Clin Oncol"},{"key":"2024092719355718700_bib8","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/S0140-6736(84)90995-4","article-title":"Steroid hormone receptors and survival after first relapse in breast cancer","volume":"i","author":"Howell","year":"1984","journal-title":"Lancet"},{"key":"2024092719355718700_bib9","first-page":"18","article-title":"Oestrogen receptors and prognosis in disseminated breast cancer. 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