{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T20:10:24Z","timestamp":1727467824877},"reference-count":13,"publisher":"Oxford University Press (OUP)","issue":"11","license":[{"start":{"date-parts":[[1987,11,1]],"date-time":"1987-11-01T00:00:00Z","timestamp":562723200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1987,11,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Changes in mucosal blood flow may occur in many gastrointestinal disorders, but assessment is impossible without a non-invasive in vivo technique. We have compared endoscopic laser Doppler (LD) with oxygen electrode (OE) measurements in a dog isolated colon preparation, using variable perfusion measured with an electromagnetic flow probe. At maximum flow, LD measurements were made at three sites to compare mucosal with serosal readings. Flow rate was varied (1-38 ml\/min) and measurements of microcirculatory flux obtained using LD, and of oxygen tension using a serosal OE. A progressive trend towards increasing flux was demonstrated from caecum to rectum\u2014serosa: 46\u00b78 \u00b1 18\u00b77 V (caecum), 52\u00b76 \u00b1 17\u00b79 V (mid-colon) and 61\u00b73 \u00b1 17\u00b76 V (rectum). A parallel trend was observed in mucosal values: 41\u00b71 \u00b1 18\u00b72 V (caecum), 45\u00b77 \u00b1 15\u00b72 V (mid-colon) and 54\u00b71 \u00b1 15\u00b71 V (rectum). At all sites, serosal and mucosal values were not significantly different (Student's t test). LD serosal values correlated significantly with EM flow (r = 0\u00b7544, 0\u00b701 &amp;gt; P &amp;gt; 0\u00b7001). A similar linear correlation was found between OE and EM flow (r = 0\u00b765, P&amp;lt;0\u00b7001). Oxygen tension measurements varied as expected with microcirculatory flux (r = 0\u00b7441, 0\u00b702 &amp;gt; P &amp;gt; 0\u00b701). Endoscopic LD assessment of colonic microcirculation accurately reflects changes in blood flow.<\/jats:p>","DOI":"10.1002\/bjs.1800741131","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T08:48:46Z","timestamp":1172911726000},"page":"1053-1055","source":"Crossref","is-referenced-by-count":12,"title":["Non-invasive endoscopic technique to assess gastrointestinal perfusion"],"prefix":"10.1093","volume":"74","author":[{"given":"P I M","family":"Allen","sequence":"first","affiliation":[{"name":"East Birmingham Hospital , Bordesley Green East, Birmingham B9 5ST,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D","family":"Gourevitch","sequence":"additional","affiliation":[{"name":"East Birmingham Hospital , Bordesley Green East, Birmingham B9 5ST,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M","family":"Goldman","sequence":"additional","affiliation":[{"name":"East Birmingham Hospital , Bordesley Green East, Birmingham B9 5ST,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1987,11,1]]},"reference":[{"key":"2024092719354593600_bib1","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1109\/TBME.1978.326374","article-title":"An instrument to measure cutaneous blood flow using the Doppler shift of laser light","volume":"25","author":"Watkins","year":"1978","journal-title":"IEEE Trans Biomed Eng"},{"key":"2024092719354593600_bib2","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1109\/TBME.1980.326582","article-title":"Evaluation of a laser Doppler flowmeter for measurement of tissue blood flow","volume":"27","author":"Nilsson","year":"1980","journal-title":"IEEE Trans Biomed Eng"},{"key":"2024092719354593600_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1113\/jphysiol.1980.sp013106","article-title":"The measurement of colonic mucosal-submucosal blood flow in man","volume":"299","author":"Forrester","year":"1980","journal-title":"J Physiol"},{"key":"2024092719354593600_bib4","first-page":"31","article-title":"Radioactive microsphere techniques for studies of the circulation","volume-title":"Clin Exp Pharm Physiol","author":"Hales","year":"1974"},{"key":"2024092719354593600_bib5","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1152\/ajplegacy.1968.215.2.486","article-title":"Use of radioactive microspheres to assess distribution of cardiac output in rabbits","volume":"215","author":"Neutze","year":"1968","journal-title":"Am J Physiol"},{"key":"2024092719354593600_bib6","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/S0016-5107(84)72391-1","article-title":"Laser Doppler velocimetry: a new technique for the measurement of intestinal mucosal blood flow","volume":"30","author":"Feld","year":"1984","journal-title":"Gastro Endoscopy"},{"key":"2024092719354593600_bib7","first-page":"11","volume-title":"Stockholm. Periflux PF2 User's Handbook","author":"Perimed","year":"1985","edition":"1"},{"key":"2024092719354593600_bib8","first-page":"282","article-title":"Blood flow and flow distribution in the small intestine of the cat as analysed by the Kr85 washout technique","volume":"72","author":"Kampp","year":"1968","journal-title":"Acta Physiol Scand"},{"key":"2024092719354593600_bib9","first-page":"6668","article-title":"Continuous measurement of intestinal mucosal blood flow by laser Doppler velocimetry","volume":"242","author":"Shepherd","year":"1982","journal-title":"Am J Physiol"},{"key":"2024092719354593600_bib10","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/S0016-5085(85)80013-5","article-title":"Evaluation of laser Doppler flowmetry in the assessment of intestinal blood flow in cat","volume":"88","author":"Ahn","year":"1985","journal-title":"Gastroenterology"},{"key":"2024092719354593600_bib11","first-page":"135","volume-title":"Measurement of gastrointestinal blood flow with laser Doppler flowmetry","author":"Ahn","year":"1986"},{"key":"2024092719354593600_bib12","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/1523-1747.ep12514556","article-title":"Cutaneous blood flow responses to injection trauma measured by laser Doppler flowmetry","volume":"74","author":"Holloway","year":"1980","journal-title":"J Invest Dermatol"},{"key":"2024092719354593600_bib13","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/bjs.1800720808","article-title":"Colonic anastomosis healing and oxygen tension","volume":"72","author":"Shandall","year":"1985","journal-title":"Br J Surg"}],"container-title":["Journal of British Surgery"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbjs.1800741131","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/74\/11\/1053\/59382628\/bjs1800741131.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/bjs\/article-pdf\/74\/11\/1053\/59382628\/bjs1800741131.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T19:36:06Z","timestamp":1727465766000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/bjs\/article\/74\/11\/1053\/6186241"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1987,11,1]]},"references-count":13,"journal-issue":{"issue":"11","published-online":{"date-parts":[[1987,11,1]]},"published-print":{"date-parts":[[1987,11,1]]}},"URL":"https:\/\/doi.org\/10.1002\/bjs.1800741131","relation":{},"ISSN":["0007-1323","1365-2168"],"issn-type":[{"type":"print","value":"0007-1323"},{"type":"electronic","value":"1365-2168"}],"subject":[],"published-other":{"date-parts":[[1987,11]]},"published":{"date-parts":[[1987,11,1]]}}}