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Prostaglandins have pathophysiological significance and prostaglandin synthesis inhibitors such as indomethacin inhibit fluid secretion by gallbladder mucosa, reduce distension and relieve pain. Nerves in the gallbladder wall are involved in disturbed mucosal function, and the benefits of opiates may derive from reduction of active fluid secretion in the inflamed and obstructed gallbladder as well as from central analgesic effects.<\/jats:p>","DOI":"10.1002\/bjs.1800741205","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T08:45:25Z","timestamp":1172911525000},"page":"1084-1086","source":"Crossref","is-referenced-by-count":31,"title":["Pathophysiology of acute obstructive cholecystitis: Implications for non-operative management"],"prefix":"10.1093","volume":"74","author":[{"given":"L","family":"Jiveg\u00e5rd","sequence":"first","affiliation":[{"name":"Department of Surgery I, Sahlgrenska Hospital , S-41345 Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E","family":"Thornell","sequence":"additional","affiliation":[{"name":"Department of Surgery I, Sahlgrenska Hospital , S-41345 Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Svanvik","sequence":"additional","affiliation":[{"name":"Department of Surgery I, Sahlgrenska Hospital , S-41345 Gothenburg,","place":["Sweden"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1987,12,1]]},"reference":[{"key":"2024092719412629300_bib1","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1097\/00000658-198004000-00018","article-title":"Early cholecystectomy for acute cholecystitis\u2014A prospective randomized study","volume":"191","author":"J\u00e4rvinen","year":"1980","journal-title":"Ann Surg"},{"key":"2024092719412629300_bib2","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/bjs.1800700309","article-title":"Early or delayed cholecystectomy in acute cholecystitis? 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