{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:21:44Z","timestamp":1740126104681,"version":"3.37.3"},"reference-count":33,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1988,1,1]],"date-time":"1988-01-01T00:00:00Z","timestamp":567993600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"funder":[{"DOI":"10.13039\/501100006310","name":"Swedish Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006310","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The effect of splenectomy on renal allograft survival is not clear. In the rat, spleens isolated from recipients with functioning grafts have been shown to be a major source of cells that are capable of suppressing the rejection response (suppressor T lymphocytes). Thus the removal of the spleen in these allograft recipients could be detrimental to renal allograft survival. This study investigates this hypothesis, and looks for the presence of suppressor cells in other lymphoid organs apart from the spleen. In the rat renal allograft model, donor Lewis spleen cells given to DA recipients intravenously 1 week before transplantation of a Lewis kidney leads to indefinite allograft survival (median survival time (MST) &amp;gt; 100 days). Splenectomy before or after pretreatment with donor spleen cells failed to abrogate this effect (MST &amp;gt; 100 days). Experiments were performed in which cells or serum were prepared from long-term surviving splenectomized animals which had already been pretreated and transplanted, and then were injected into untreated recipients (adoptive transfer experiments). This was done to determine if cells capable of suppressing graft rejection were present in lymphoid organs outside the spleen in these splenectomized recipients. Thus the IV transfer of 108 lymph node cells harvested from splenectomized DA recipients with a long-term surviving LEW graft (LTS), into untreated but lightly irradiated (200 rad) DA recipients resulted in indefinite survival of a fresh Lewis kidney (MST &amp;gt; 100 days). In contrast, adoptive transfer of normal DA lymph node cells was ineffective (MST 13 days). Thus splenectomy is not necessarily detrimental to graft survival, as cells capable of preventing graft rejection are found in other lymphoid organs, such as lymph nodes, in splenectomized recipients.<\/jats:p>","DOI":"10.1002\/bjs.1800750108","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T10:22:46Z","timestamp":1172917366000},"page":"18-22","source":"Crossref","is-referenced-by-count":3,"title":["Splenectomy and renal allograft survival in the rat"],"prefix":"10.1093","volume":"75","author":[{"given":"D","family":"Cranston","sequence":"first","affiliation":[{"name":"Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital , Oxford,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn J","family":"Wood","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital , Oxford,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P J","family":"Morris","sequence":"additional","affiliation":[{"name":"Nuffield Department of Surgery, University of Oxford, John Radcliffe Hospital , Oxford,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,1,1]]},"reference":[{"key":"2024092719504704300_bib1","doi-asserted-by":"crossref","first-page":"929","DOI":"10.3181\/00379727-113-28534","article-title":"Splenectomy and thymectomy in human renal homo-transplantation","volume":"113","author":"Starzl","year":"1963","journal-title":"Proc Soc Exp Biol Med"},{"key":"2024092719504704300_bib2","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/00007890-196703000-00046","article-title":"Report from kidney transplant registry: analysis of variables in the function of human kidney transplants. 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Blood group compatibility and splenectomy","volume":"5","author":"Gleason","year":"1967","journal-title":"Transplantation"},{"key":"2024092719504704300_bib3","first-page":"1300","article-title":"The effect of splenectomy on the survival of first and second renal homotransplants in man","volume":"127","author":"Pierce","year":"1968","journal-title":"Surg Gynecol Obstet"},{"key":"2024092719504704300_bib4","first-page":"33","article-title":"Splenectomy in renal transplantation","volume":"139","author":"Kauffman","year":"1974","journal-title":"Surg Gynecol Obstet"},{"key":"2024092719504704300_bib5","first-page":"96","article-title":"Post-transplant hypersplenism","volume":"11","author":"Kauffman","year":"1979","journal-title":"Transplant Proc"},{"key":"2024092719504704300_bib6","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1097\/00000658-198010000-00013","article-title":"Effect of splenectomy on first cadaver kidney transplants","volume":"192","author":"Stuart","year":"1980","journal-title":"Ann Surg"},{"key":"2024092719504704300_bib7","first-page":"48","article-title":"Results of a prospective randomized study on the effect of splenectomy versus no splenectomy in renal transplant patients","volume":"13","author":"Fryd","year":"1981","journal-title":"Transplant Proc"},{"key":"2024092719504704300_bib8","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1097\/00007890-197306000-00013","article-title":"Effect of splenectomy on human renal transplants","volume":"15","author":"Opelz","year":"1973","journal-title":"Transplant Proc"},{"key":"2024092719504704300_bib9","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1097\/00007890-198310000-00005","article-title":"Assessment of prognostic factors and projection of outcome in renal transplantation","volume":"36","author":"Krakauer","year":"1983","journal-title":"Transplantation"},{"key":"2024092719504704300_bib10","first-page":"194","article-title":"Adverse effect of splenectomy in renal transplantation","volume":"9","author":"Rai","year":"1978","journal-title":"Clin Nephrol"},{"key":"2024092719504704300_bib11","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1001\/archsurg.1983.01390070007002","article-title":"Splenectomy and death in renal transplant patients","volume":"118","author":"Peters","year":"1983","journal-title":"Arch Surg"},{"key":"2024092719504704300_bib12","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1097\/00007890-198405000-00009","article-title":"The late adverse effect of splenectomy on patient survival following cadaveric renal transplantation","volume":"37","author":"Alexander","year":"1984","journal-title":"Transplantation"},{"key":"2024092719504704300_bib13","first-page":"59","article-title":"Prolonged survival of a renal homograft by simultaneous splenectomy and splenic homotransplantation","volume":"13","author":"Kountz","year":"1962","journal-title":"Surg Forum"},{"key":"2024092719504704300_bib14","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1097\/00007890-197509000-00006","article-title":"The role of the spleen in the rejection and enhancement of renal allografts in the rat","volume":"20","author":"Fabre","year":"1975","journal-title":"Transplantation"},{"key":"2024092719504704300_bib15","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1097\/00007890-197403000-00015","article-title":"Prolongation of rat cardiac allograft survival by splenectomy following transplantation","volume":"17","author":"Souther","year":"1974","journal-title":"Transplantation"},{"key":"2024092719504704300_bib16","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1097\/00007890-198601000-00023","article-title":"Splenectomy and donor-specific blood transfusion in rat cardiac allografts","volume":"41","author":"Balshi","year":"1986","journal-title":"Transplantation"},{"key":"2024092719504704300_bib17","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1097\/00007890-197608000-00011","article-title":"Graft-versus-host reactivity and renal allograft survival in rats given allogeneic spleen cells or spleen allografts","volume":"22","author":"Silber","year":"1976","journal-title":"Transplantation"},{"key":"2024092719504704300_bib18","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/S0022-5347(17)51615-8","article-title":"Effect of pretransplant blood transfusions and splenectomy on renal allograft survival in the Lewis rat","volume":"130","author":"Banowsky","year":"1983","journal-title":"J Urol"},{"key":"2024092719504704300_bib19","first-page":"389","article-title":"Effect of splenectomy alone and in combination with antilymphocyte serum on renal allograft rejection in the rat","volume":"27","author":"Evans","year":"1979","journal-title":"Transplantation"},{"key":"2024092719504704300_bib20","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/00007890-197301000-00002","article-title":"Immunological enhancement of renal allografts in the rat. 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