{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T17:19:55Z","timestamp":1761153595893},"reference-count":24,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[1988,4,1]],"date-time":"1988-04-01T00:00:00Z","timestamp":575856000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Previous studies have shown that lung metastases from a non-immunogenic sarcoma (LS175) in BN (homozygous for RT1n) rats were stimulated by blood transfusions. Enhanced growth was also observed after abdominal surgery combined with allogeneic blood transfusions while syngeneic blood transfusions had no effect. These experimental findings have been confirmed in retrospective clinical studies. The allogeneic blood transfusion effect may be avoided in cancer patients by autologous blood transfusions although this implies blood donation before surgery. The aim of the present study was to investigate the effect of blood loss before surgery on formation (\u2018take\u2019) of lung colonies, and on the outgrowth of established metastases in the BN rat model. These aspects of tumour behaviour were also investigated in rats undergoing surgery, or receiving blood transfusion, or both, after blood loss. The results indicate that blood loss has a profound stimulating effect on the growth of established metastases, but not on the \u2018take\u2019 of tumour cells. This stimulating effect was also present when blood loss was combined with surgery, while previously surgery alone was found to have no effect. Allogeneic and syngeneic transfusions in combination with blood loss both had a strong stimulating effect on growth of established lung metastases. The results indicate that blood loss may be an important factor in determining the outcome of metastatic growth.<\/jats:p>","DOI":"10.1002\/bjs.1800750427","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T10:51:10Z","timestamp":1172919070000},"page":"377-379","source":"Crossref","is-referenced-by-count":21,"title":["Consequences of blood loss on growth of artificial metastases"],"prefix":"10.1093","volume":"75","author":[{"given":"S K","family":"Sing","sequence":"first","affiliation":[{"name":"Department of Surgery and Laboratory of Experimental Surgery, Erasmus University Rotterdam , P.O. Box 1738, 3000 DR Rotterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R L","family":"Marquet","sequence":"additional","affiliation":[{"name":"Department of Surgery and Laboratory of Experimental Surgery, Erasmus University Rotterdam , P.O. Box 1738, 3000 DR Rotterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R W F","family":"de Bruin","sequence":"additional","affiliation":[{"name":"Department of Surgery and Laboratory of Experimental Surgery, Erasmus University Rotterdam , P.O. Box 1738, 3000 DR Rotterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W C J","family":"Hop","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Erasmus University Rotterdam , P.O. Box 1738, 3000 DR Rotterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D L","family":"Westbroek","sequence":"additional","affiliation":[{"name":"Department of Surgery and Laboratory of Experimental Surgery, Erasmus University Rotterdam , P.O. Box 1738, 3000 DR Rotterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Jeekel","sequence":"additional","affiliation":[{"name":"Department of Surgery and Laboratory of Experimental Surgery, Erasmus University Rotterdam , P.O. 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