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Different needle sizes (23G, 21G, 19G) passed in random order, five, ten and fifteen times into the tumours, were compared. The type of tumour, needle size and number of passes independently and significantly influenced cell yield. A 21G(green) needle passed into the tumour at least 10 times was the most efficient in obtaining cells. This in vitro study could explain the variation in the reported accuracy of fine needle aspiration cytology from groups using different techniques and is perhaps one reason why the highest diagnostic accuracy and the lowest rate of unsatisfactory aspirates comes from a centre which uses a 21G needle and at least 10 passes through the tumour.<\/jats:p>","DOI":"10.1002\/bjs.1800750428","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T10:51:10Z","timestamp":1172919070000},"page":"380-381","source":"Crossref","is-referenced-by-count":13,"title":["Fine needle aspiration cytology: An in vitro study of cell yield"],"prefix":"10.1093","volume":"75","author":[{"given":"M N","family":"Hartley","sequence":"first","affiliation":[{"name":"Departments of Surgery and Pathology, Warrington District General Hospital , Warrington,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D J","family":"Tuffnell","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Pathology, Warrington District General Hospital , Warrington,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane L","family":"Hutton","sequence":"additional","affiliation":[{"name":"Department of Statistics and Computational Mathematics, University of Liverpool , Liverpool,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret","family":"Palmer","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Pathology, Warrington District General Hospital , Warrington,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M S","family":"Al-Jafari","sequence":"additional","affiliation":[{"name":"Departments of Surgery and Pathology, Warrington District General Hospital , Warrington,","place":["UK"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,4,1]]},"reference":[{"key":"2024092719520952200_bib1","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1016\/S0140-6736(83)90585-8","article-title":"Fine needle aspiration of the breast: importance of the operator","volume":"ii","author":"Dixon","year":"1983","journal-title":"Lancet"},{"key":"2024092719520952200_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1097\/00000658-197507000-00001","article-title":"The diagnostic accuracy of palpation and fine needle biopsy and an evaluation of their combined use in the diagnosis of breast lesions","volume":"182","author":"Rimsten","year":"1975","journal-title":"Ann Surg"},{"key":"2024092719520952200_bib3","first-page":"249","article-title":"Cytologic diagnosis of mammary tumours from aspiration biopsy smears iii. 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