{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,21]],"date-time":"2026-03-21T13:21:49Z","timestamp":1774099309481,"version":"3.50.1"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"5","license":[{"start":{"date-parts":[[1988,5,1]],"date-time":"1988-05-01T00:00:00Z","timestamp":578448000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/journals\/pages\/open_access\/funder_policies\/chorus\/standard_publication_model"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":[],"published-print":{"date-parts":[[1988,5,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>In order to assess the effect of the no-touch isolation technique, in the treatment of large bowel cancers, on the site of first recurrence and disease-free and overall survival, 236 patients were prospectively and randomly assigned to either the no-touch isolation technique (117 patients) or to a conventional resection technique (119 patients). No patient with distant metastases or unresectable disease entered the study. The two treatment groups were comparable with regard to patient characteristics. Pre- and postoperative complications (including mortality within 30 days) were similar in both groups. After a complete follow-up of 5 years, a tendency for reduction in the number of, and time to, occurrences of liver metastases was seen in the no-touch isolation group (P = 0.14). This effect was most obvious in the sigmoid colon with angio-invasive growth. Overall (P = 0.42) and corrected (P = 0.25) survival did not differ significantly among the treatment groups although in every analysis the survival data of the no-touch isolation group were superior. The data do suggest a limited benefit of the no-touch isolation technique. This observation is important since the morbidity and mortality of surgery were equal in both groups.<\/jats:p>","DOI":"10.1002\/bjs.1800750505","type":"journal-article","created":{"date-parts":[[2007,3,3]],"date-time":"2007-03-03T10:49:56Z","timestamp":1172918996000},"page":"409-415","source":"Crossref","is-referenced-by-count":186,"title":["No-Touch isolation technique in colon cancer: A controlled prospective trial"],"prefix":"10.1093","volume":"75","author":[{"given":"T","family":"Wiggers","sequence":"first","affiliation":[{"name":"Departments of Surgery, University Hospital Maastricht , Maastricht,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J","family":"Jeekel","sequence":"additional","affiliation":[{"name":"University Hospital Dijkzigt , Rotterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J W","family":"Arends","sequence":"additional","affiliation":[{"name":"Department of Pathology, University Hospital Maastricht , Maastricht,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A P","family":"Brinkhorst","sequence":"additional","affiliation":[{"name":"Ikazia Hospital , Rotterdam,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H M","family":"Kluck","sequence":"additional","affiliation":[{"name":"St. Joseph Hospital , Eindhoven,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C I","family":"Luyk","sequence":"additional","affiliation":[{"name":"Gregorius de Grote Hospital , Brunssum,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J D K","family":"Munting","sequence":"additional","affiliation":[{"name":"De Wever Hospital , Heerlen,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J A C M","family":"Povel","sequence":"additional","affiliation":[{"name":"St. Barbara Hospital , Geleen,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A P M","family":"Rutten","sequence":"additional","affiliation":[{"name":"Laurentius Hospital , Roermond,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Volovics","sequence":"additional","affiliation":[{"name":"Department of Statistics, University of Limburg , Maastricht,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J M","family":"Greep","sequence":"additional","affiliation":[{"name":"Departments of Surgery, University Hospital Maastricht , Maastricht,","place":["The Netherlands"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,5,1]]},"reference":[{"key":"2024092719510377800_bib1","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1056\/NEJM198403223101201","article-title":"Adjuvant therapy of colon cancer\u2014results of a prospectivey randomized trial","volume":"310","author":"Gastrointestinal Tumor Study Group","year":"1984","journal-title":"N Engl J Med"},{"key":"2024092719510377800_bib2","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1002\/1097-0142(197508)36:2+<696::AID-CNCR2820360813>3.0.CO;2-X","article-title":"Intracavitary irradiation of early rectal cancer for cure","volume":"36","author":"Papillon","year":"1975","journal-title":"Cancer"},{"key":"2024092719510377800_bib3","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1056\/NEJM198506063122301","article-title":"Prolongation of the disease-free interval in surgically treated rectal carcinoma","volume":"312","author":"Gastrointestinal Tumor Study Group","year":"1985","journal-title":"N Engl J Med"},{"key":"2024092719510377800_bib4","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1056\/NEJM197507172930305","article-title":"Trends in survival rates of patients with cancer","volume":"293","author":"Cutler","year":"1975","journal-title":"N Engl J Med"},{"key":"2024092719510377800_bib5","first-page":"28","article-title":"Cancer of the colon and rectum: comparison of the results of three groups of surgeons using different techniques","volume":"16","author":"P\u00e9loquin","year":"1973","journal-title":"Car. 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